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Novel nano bioceramic coated artificial ligament and preparation method of ligament

A bioceramic and artificial ligament technology, applied in coating, medical science, prosthesis, etc., can solve the problems of unsatisfactory bone healing of grafts, poor repeatability of experimental results, lack of coating thickness, etc., and achieve strong practical significance. , The parameters are easy to control, the effect of good biological activity

Active Publication Date: 2014-06-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main problems in the current PET artificial ligament coating research are: (1) the coating method is single, the coating is uneven, the stability is poor, and the repeatability of the experimental results is poor; (2) the coating effect is slow, and the transplantation (3) Lack of relevant effects of different coating thicknesses, crystallinity and grain size on in vitro cells and in vivo osteogenesis

Method used

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  • Novel nano bioceramic coated artificial ligament and preparation method of ligament
  • Novel nano bioceramic coated artificial ligament and preparation method of ligament
  • Novel nano bioceramic coated artificial ligament and preparation method of ligament

Examples

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Effect test

example 1

[0068] The experiment uses KrF laser (wavelength 248nm, pulse width 20ns). The laser frequency is 5 Hz, the distance between the artificial ligament and the ceramic target is 5.5 cm, and the laser beam forms an angle of 45 degrees with the target surface. In order to improve the uniformity of the deposited film and prevent the target from being broken down, the Ca-Mg-Si ceramic rotates at a speed of 2400r / hr during the deposition process, and the deposition chamber is evacuated to 20Pa by a molecular pump, and its pressure is controlled by a mechanical pump. In this experiment, the thickness, crystallinity and grain size of the coating are mainly controlled by adjusting the deposition temperature (room temperature), atmosphere pressure (20Pa), target-base distance (5.5cm) and deposition time (40 minutes). Material characterization, vascularization, osteogenesis, and graft bone healing performance studies were then performed.

example 2

[0070] The experiment uses KrF laser (wavelength 248nm, pulse width 20ns). The frequency of the laser is 6 Hz, the distance between the artificial ligament and the ceramic target is 6 cm, and the laser beam is at an angle of 30 degrees to the surface of the target. In order to improve the uniformity of the deposited film and prevent the target from being broken down, the Ca-Mg-Si ceramic rotates at a speed of 2400r / hr during the deposition process, and the deposition chamber is evacuated to 20Pa by a molecular pump, and its pressure is controlled by a mechanical pump. In this experiment, the thickness, crystallinity and grain size of the coating are mainly controlled by adjusting the deposition temperature (room temperature), atmosphere pressure (20Pa), target-base distance (6cm) and deposition time (10 minutes).

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Abstract

The invention relates to a novel nano bioceramic coated artificial ligament and a preparation method of the ligament. The novel nano bioceramic coated artificial ligament comprises an artificial ligament and a Ca-Mg-Si bioceramic coating which is uniformly coated on the surface of the artificial ligament, wherein the grain size of ceramic particles of the Ca-Mg-Si bioceramic coating is 20-80nm. By coating the Ca-Mg-Si bioceramic coating on the surface of the artificial ligament, the artificial ligament coated by the coating has multifunctional characteristics of good biological activity, bone formability, bone graft union and the like by means of excellent bone induction capacity of the Ca-Mg-Si bioceramic, so that the artificial ligament becomes a novel graft material with the biological activity.

Description

technical field [0001] The invention relates to a novel artificial ligament coated with nano-biological ceramics and its preparation method and application, belonging to the field of biological materials. Background technique [0002] The anterior cruciate ligament (ACL) is difficult to heal itself after injury, and conservative treatment is ineffective, and the functional recovery is incomplete. It is very easy for athletes to re-injure repeatedly after returning to the field. The treatment of ACL injury is a hot and difficult point in the research of sports medicine at home and abroad. At present, ACL reconstruction surgery is the main method for the treatment of ACL injury, and the stability of the knee joint can be restored after surgery [1]. Graft options for ACL reconstruction include tendon autograft, tendon allograft, and artificial ligament. Autologous tendon grafts are widely used, but there are problems such as tendon donor site damage, delayed rehabilitation ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/50
Inventor 吴成铁李宏常江陈世益
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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