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Preparation method and medicinal application of blood fat-reducing active component

A hypolipidemic and active technology, used in medicine, in the field of ginseng active components

Inactive Publication Date: 2014-06-25
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is the first time to isolate the active component that can inhibit DGAT1 from ginseng. After multiple pharmacological experiments, it is found that the active component has a significant inhibitory effect on DGAT1 activity and lowering blood lipids. After literature search, no such plant has this aspect. report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Weigh 300g of dried ginseng, add 1 to 2 times the amount of 50% ethanol to soak for 1 hour, use ultrasonic extraction for 1 to 3 hours, filter and collect the filtrate; concentrate the filtrate with a rotary evaporator, collect the concentrate, let it cool, add 2-3 times the amount of water and stirred, let it stand at room temperature for 24 hours, precipitated, filtered or centrifuged to take the precipitate, heated the precipitate in a watch glass, removed ethanol and water, until there was no alcohol smell, and obtained the ginseng alcohol extract; The ginseng alcohol extract was subjected to 150 μm reversed-phase chromatography, and gradient elution was carried out with methanol / water (V / V, 0:10-10:0) as the mobile phase, and the collected separated components were detected by reversed-phase thin-layer chromatography. Separate components with the same composition were combined and concentrated to obtain ten separate components from F1 to F10. The F2 component was s...

Embodiment 2

[0045] According to the conventional method of pharmacy, the active component prepared in Example 1 can be dried, mixed with one or more pharmaceutically acceptable carriers or excipients, and prepared into various preparations suitable for administration through the gastrointestinal tract. Various conventional dosage forms of medicines. For example, the dry powder prepared above is aseptically filled into capsules according to conventional methods to obtain the active ingredient medicine of the present invention in capsule dosage form. The active ingredient of the present invention may be formulated into tablets, capsules, pills, powders, suppositories and solutions and suspensions according to methods known in the pharmaceutical industry. Among them, capsules and tablets suitable for gastrointestinal administration are preferred. When preparing dosage forms suitable for oral administration, sucrose, lactose, galactose, corn starch, gelatin, microcrystalline cellulose, carbo...

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PUM

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Abstract

The invention relates to a preparation method of a blood fat-reducing active component and medicinal application, relating to the technical field medicine, in particular to a component having diacylglycerol acyltransferase 1 (DGAT1) inhibiting activity obtained by extracting and separating from araliaceae panax plant ginseng. As proved by repeated in-vitro diacylglycerol acyltransferase inhibiting experiments, the component has remarkable DGAT1 inhibiting activity, and can be applied to preparation of medicaments for treating and preventing hyperlipidemia, atherosclerosis, obesity and complications thereof, and has important significance to the development and utilization of medicinal plant resources in China.

Description

technical field [0001] The invention relates to an active component of ginseng for treating hyperlipidemia, discloses the active component with hypolipidemic effect and its extraction method, and also provides its medical application. The active component of the present invention has been tested by diacylglycerol acyltransferase 1 (Diacylgycerol Acyltransferase, DGAT1) in vitro for many times, which shows that the active component can significantly inhibit the activity of DGAT1, and can be used in the preparation of blood lipid-lowering, anti-atherosclerosis, anti-atherosclerosis The application in weight and complication medicine relates to the technical field of traditional Chinese medicine. Background technique [0002] Hyperlipidemia mainly refers to the high level of serum total cholesterol (TC) or triacylglycerol (TG) and / or the low level of serum high-density lipoprotein-cholesterol (HDL-C), which cause a series of serious harm to the human body. Healthy disease. Wi...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/06A61P9/10A61P3/04
Inventor 崔龙张南李佳琳李娜马坤邢姗姗
Owner BEIHUA UNIV
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