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A kind of pharmaceutical composition for treating oral candidiasis and its application

A candidiasis and composition technology, which is applied in the field of pharmaceutical compositions for the treatment of oral candidiasis, can solve the problems of affecting cell membrane permeability, having nausea, vomiting, and being unacceptable to patients, and achieves low cost and high recurrence rate. Low, fast-acting effect

Inactive Publication Date: 2015-09-30
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nystatin is a commonly used drug for the clinical treatment of oral candidiasis, but it has poor taste and side effects such as nausea and vomiting, making it difficult for patients to accept
Conazole drugs such as ketoconazole can inhibit the biosynthesis of ergosterol in the fungal cell membrane, affect the permeability of the cell membrane, thereby inhibiting its growth, but conazole drugs can cause headaches, gastrointestinal discomfort, skin itching, and liver damage after long-term use and other side effects

Method used

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  • A kind of pharmaceutical composition for treating oral candidiasis and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 15g of Asarum, 50g of Manjiang Red, 8g of Evodia and 10g of Cork, wash and remove impurities, dry, wrap with gauze, put in a casserole, add 0.8L of water, soak for 30 minutes, heat to boiling, continue to cook for 30 Minutes, filter, and concentrate the filtrate to contain 3g crude drug per milliliter to obtain a gargle.

Embodiment 2

[0018] Weigh 18g of Asarum, 42g of Manjiang Red, 8g of Evodia and 12g of Cork, wash and remove impurities, dry, wrap with gauze, put in a casserole, add 1L of water, soak for 30 minutes, heat to boiling, continue to decoct for 30 minutes , Filter, concentrate the filtrate to 3g crude drug per ml, get a gargle.

Embodiment 3

[0020] Weigh 13g of Asarum, 60g of Manjiang Red, 8g of Evodia and 8g of Cork, wash and remove impurities, dry, wrap with gauze, put in a casserole, add 1L of water, soak for 30 minutes, heat to boiling, continue to decoct for 30 minutes , Filter, concentrate the filtrate to 3g crude drug per ml, get a gargle.

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Abstract

The invention discloses a medicine composition for treating oral candidiasis. The medicine composition is prepared from the following traditional Chinese raw materials in parts by weight: 13-18 parts of asarum, 42-60 parts of azolla imbricate, 7-10 parts of fructus evodiae and 8-12 parts of golden cypress by boiling in water. The medicine composition disclosed by the invention has the effects of clearing away heat and toxic materials and inhibiting fungus, and moreover the medicine liquid can directly act on infectious parts, and is good in absorption and allows fast effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a pharmaceutical composition for treating oral candidiasis and its application. Background technique [0002] Candida is a conditional pathogenic fungus that exists in the oral cavity and can manifest as healthy carriers without clinical symptoms or oral candidiasis with clinical signs. Some scholars have isolated yeast-like bacteria from the lesions of patients with aphthous ulcers, and believe that this type of bacteria belongs to Candida, Candida gori, and Candida pseudotropical in the Cryptococcus family. Among them, Candida albicans is the most important pathogen. When the body's flora is imbalanced, immune function declines or immunity is lost, the infection rate and incidence rate can increase. Long-term chronic oral candidiasis, especially proliferative Candida stomatitis may be malignant, so it is very important to treat oral candidiasis as s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P1/02A61P31/02A61P31/10
Inventor 国娥香赵晓梅张勇哲蔡洁凤姜明
Owner QINGDAO MUNICIPAL HOSPITAL