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Stellera chameajasme component film-coated tablet

A technology of Daphne chamaema chamaejasme and film-coated tablets, which can be applied to sugar-coated pills, drug combinations, medical preparations containing active ingredients, etc., and can solve the problems of poor stability, poor solubility in water, and poor stability of preparations

Inactive Publication Date: 2014-07-02
NANTONG CAMBRIDGE OLEIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The existing Rhizoma chamaejasma preparations include chamaejasma injection, chamaejasma solution (external use), chamaejasma ointment, etc. The main active ingredient is ethanol extract or water extract. Due to the simple extraction process, it contains a large number of mixed ingredients, causing side effects of the preparation Large, poor preparation stability, high toxicity and poor curative effect
[0015] Using high-purity extracts, some are difficult to make suitable preparations, some have poor stability, some are difficult to dissolve in water, and have low bioavailability, etc.

Method used

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  • Stellera chameajasme component film-coated tablet
  • Stellera chameajasme component film-coated tablet
  • Stellera chameajasme component film-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Preparation of Daphne chamaejasme Component 1:

[0078] A Daphne chamaejasme extract is characterized in that it is prepared by the following method:

[0079] Step 1. After pulverizing 1 kg of Rhizoma chamaejasma, add 10 L of acetone: ethanol = 2: 1 (v: v) mixed solution, heat and reflux for 1 hour, filter out the extract, and add 10 L of acetone: ethanol = 2: 1 ( The mixed solution of v: v) was heated to reflux for 1 hour, the extract was filtered out, and the filtrate was combined to obtain the extract;

[0080] Step 2, recover the solvent from the combined extract under reduced pressure, concentrate and dry to obtain 85g of dry extract, take 2kg of HPD100 type macroporous resin, mix the sample with the dry extract; first, use ethanol:ethyl acetate=1: 1 (v: v) 5 L was used as the mobile phase for elution, and then 95% ethanol (v: v) 5 L was used as the mobile phase to elute to obtain an eluent. After recovering the ethanol, the eluate was concentrated and dried to ob...

Embodiment 2

[0085] Tablet preparation

[0086] The components obtained in Example 1 are used as pharmaceutical active ingredients, added with pharmaceutical carriers, and prepared according to the conventional techniques of pharmacy, such as the following preparation method:

[0087] 10 mg of component 1, 200 mg of starch, 100 mg of powdered sugar, appropriate amount of magnesium stearate, using starch paste as a binder, mixing, granulating, air-drying, sizing, and tableting to obtain tablets.

[0088] Tablet stability test:

[0089] 100 mg of component 1 and the tablet prepared by the above method were placed in an incubator at 40° C., and observed after 3 months, the appearance and color did not change in any way.

Embodiment 3

[0091] Preparation of sugar-coated tablets

[0092] The components obtained in Example 1 are used as pharmaceutical active ingredients, added with pharmaceutical carriers, and prepared according to the conventional techniques of pharmacy, such as the following preparation method:

[0093] 10mg of component 1, 200mg of starch, 100mg of powdered sugar, appropriate amount of magnesium stearate, using starch paste as a binder, mixing, granulating, air-drying, sizing, tableting to obtain tablets, and coating with syrup to obtain sugar coating piece.

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Abstract

The invention relates to a stellera chameajasme component film-coated tablet, wherein the component is prepared by the following steps: extracting stellera chameajasme by an acetone-ethanol mixed solution; filtering the extract through macroporous resin and gradient eluting by preparative chromatography, wherein the moving phase A is water and the moving phase B is acetonitrile; and collecting the eluant within 45-50 minutes, and concentrating and drying to obtain the component.

Description

Technical field: [0001] The invention relates to an anti-tumor traditional Chinese medicine extract, in particular to an anti-tumor extract extracted from the traditional Chinese medicine Daphne chamaejasme and its extraction method and application. Background technique: [0002] Chinese herbal medicine Stellera chamaejasme, English name: RADIX STELLERAE CHAMAEJASMES, is the dry root of Stellera chamaejasme. Excavated in autumn, removed impurities and dried in the sun, the medicinal materials are spindle-shaped, conical or long cylindrical, slightly curved, single or branched, varying in length, with remnants of aboveground stems at the root, brown to tan surface, and twisted Longitudinal grooves and raised lenticels and lateral root scars, and white soft fibers are exposed at the cork peeling off. Light in body, tough in quality, not easy to break, and the section is fibrous. The cortex is white, and the wood is white. Slight gas, slightly pungent taste, slightly lower t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K9/28A61K45/00A61P35/00A61P19/02A61P29/00A61K125/00
Inventor 陆建军钱国栋
Owner NANTONG CAMBRIDGE OLEIN
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