A method for improving the toughness of calcium phosphate bone cement

A technology of calcium phosphate bone cement and calcium phosphate powder, applied in medical science, prosthesis and other directions, can solve the problems of human harm, uncontrollable degradation rate, non-degradation of reinforcing fibers, etc., to achieve accelerated degradation, good biocompatibility, The effect of high porosity

Active Publication Date: 2016-01-20
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a method for improving the toughness of calcium phosphate composite bone cement to overcome the fact that the existing reinforcing fibers do not degrade in the human body, and often have monomer release and other degradation in the physiological environment or after being implanted in the body The formation of the product will cause harm to the human body, and the residue in the human body after the operation will have adverse effects on the human body, or the defect of uncontrollable degradation rate. On the basis of the calcium phosphate inorganic bone cement that has been developed and widely used, according to the bionic bone natural Structure, the poly(lactide-co-glycolide), PLGA nanofibrous membrane with good biocompatibility and controllable degradation is combined with calcium phosphate bone cement, so as to realize organic-inorganic composite and improve material toughness

Method used

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  • A method for improving the toughness of calcium phosphate bone cement
  • A method for improving the toughness of calcium phosphate bone cement

Examples

Experimental program
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Embodiment 1

[0018] Take calcium phosphate bone cement (CPC, the solid phase is calcium phosphate powder, purchased from Shanghai Ruibang Biomaterials Co., Ltd.), and the liquid phase is 2% Na 2 HPO 4 solution. Mix 1 g of calcium phosphate powder with 0.3 mL of 2% Na 2 HPO 4 The solution was mixed to prepare a thin paste of CPC, and the mixture was smeared on the surface of an electrospun PLGA nanofiber membrane (provided by the Biomaterials Center of the Netherlands Dental Academy) with a length of 20 mm and a width of 20 mm, with a thickness of 0.3 mm, and the PLGA nanofiber membrane Roll coaxially from one end to the other end, roll into a cylinder, put it into a mold filled with a little thin paste CPC in advance, clean up the CPC paste overflowing the mold, and place the test piece in a constant temperature water bath box with a constant temperature of 37°C and 100% relative humidity After 24 hours of curing, demould and take out the test piece. Example 2

Embodiment 2

[0019] Take calcium phosphate bone cement (CPC, the solid phase is calcium phosphate powder, purchased from Shanghai Ruibang Biomaterials Co., Ltd.), and the liquid phase is 2% Na 2 HPO 4 solution. Mix 1 g of calcium phosphate powder with 0.3 mL of 2% Na 2 HPO 4 The solution was mixed to prepare a thin paste of CPC, and the mixture was smeared on the surface of an electrospun PLGA nanofiber membrane (provided by the Biomaterials Center of the Netherlands Dental Academy) with a length of 20 mm and a width of 20 mm, with a thickness of 1 mm. The PLGA nanofiber membrane was made of One end is coaxially rolled to the other end, rolled into a cylinder, put into the mold, and the CPC paste overflowing the mold is cleaned. The specimen was cured in a constant temperature water bath box with a constant temperature of 37°C and a relative humidity of 100% for 24 hours, and then demoulded, and the specimen was taken out.

[0020] The following are the specific experimental methods an...

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Abstract

The invention relates to calcium phosphate bone cement, and in particular relates to a method for improving the toughness of calcium phosphate bone cement. The method for improving the toughness of calcium phosphate bone cement, which is disclosed by the invention, comprises the following steps: painting the calcium phosphate bone cement onto the surface of a PLGA (Poly(Lactic-Co-Glycolic Acid) nanofiber membrane to form single-layer compounding; coaxially coiling the PLGA nanofiber membrane from one end to the other end; and curing to obtain a cured body. According to the method, the adopted fiber membrane raw material is PLGA, has the advantages of nontoxicity, complete biodegradability, controllable degradation rate, high biocompatibility, no pollution to the environment and the like, and does not cause any adverse reaction after being implanted into the human body.

Description

technical field [0001] The invention relates to calcium phosphate bone cement, in particular to a method for improving the toughness of calcium phosphate bone cement. Background technique [0002] Calcium phosphate bone cement (Calciumphosphate cement, CPC) refers to a class of inorganic materials with various calcium phosphate salts as the main component, which have self-curing ability, degradation activity and osteogenesis activity under physiological conditions. As a new type of self-curing biomaterial, it has better physical, chemical and biological properties than traditional bone cement materials. Among artificial synthetic materials, calcium phosphate bone cement has unique advantages: on the one hand, the cured product is hydroxyapatite , which is consistent with the inorganic mineral composition of human bone, has good biocompatibility, bioactivity and osteoconductivity; The advantages of sustained drug release. Existing calcium phosphate bone cement products main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/58
Inventor 廖红兵黄琳惠
Owner GUANGXI MEDICAL UNIVERSITY
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