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Preparation method for Gd2O3 nanoparticle controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography

A nanoparticle, dopamine technology, applied in the field of biomedical imaging technology and nanomedicine, to achieve the effect of contrast enhancement, obvious contrast, and increase signal intensity

Inactive Publication Date: 2014-07-16
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported in the literature that ultra-small Gd 2 o 3 Preparation of nanoparticles, but for ultra-small Gd 2 o 3 Dopamine modification on the surface of nanoparticles for contrast imaging has not been reported

Method used

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  • Preparation method for Gd2O3 nanoparticle controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography
  • Preparation method for Gd2O3 nanoparticle controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography
  • Preparation method for Gd2O3 nanoparticle controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography

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Embodiment 1

[0024] A controllable surface-modified Gd for positive enhancement of dopamine in MRI imaging 2 o 3 A method for preparing nanoparticles, which comprises the steps of:

[0025] 1) Ultra-small Gd 2 o 3 Preparation of nanoparticles: using high temperature "polyol" method, using diethylene glycol DEG as solvent and complexing agent, sodium hydroxide NaOH as hydrolyzing agent, and gadolinium chloride hexahydrate GdCl 3 ·6H 2 O reaction, in which the molar ratio of sodium hydroxide to gadolinium chloride is 1-2:1, and the synthesis of ultra-small Gd with a particle size of less than 10nm 2 o 3 Nanoparticles.

[0026] 2mmol GdCl 3 ·6H 2 O was dissolved in 10mL of diethylene glycol, the concentration of gadolinium chloride was 0.2mol / L, and the dissolution temperature was 140°C, 2.5mmol of sodium hydroxide was dissolved in 10mL of diethylene glycol, and the concentration of sodium hydroxide was 0.25mol / L. The gadolinium chloride diethylene glycol solution and the sodium hydr...

Embodiment 2

[0034] A Gd that can be used for MRI contrast-enhanced surface modification of dopamine 2 o 3 A method for preparing nanoparticles, which comprises the steps of:

[0035] 1) Ultra-small Gd 2 o 3 Preparation of nanoparticles: using high temperature "polyol" method, using diethylene glycol DEG as solvent and complexing agent, sodium hydroxide NaOH as hydrolyzing agent, and gadolinium chloride hexahydrate GdCl 3 ·6H 2 O reaction, in which the molar ratio of sodium hydroxide to gadolinium chloride is 1-2:1, and the synthesis of ultra-small Gd with a particle size of less than 10nm 2 o 3 Nanoparticles.

[0036] 2mmol GdCl 3 ·6H 2 O was dissolved in 10mL of diethylene glycol, the concentration of gadolinium chloride was 0.2mol / L, and the dissolution temperature was 140°C, 2.5mmol of sodium hydroxide was dissolved in 10mL of diethylene glycol, and the concentration of sodium hydroxide was 0.25mol / L. The gadolinium chloride diethylene glycol solution and the sodium hydroxide ...

Embodiment 3

[0043] A Gd that can be used for MRI contrast-enhanced surface modification of dopamine 2 o 3 A method for preparing nanoparticles, which comprises the steps of:

[0044] 1) Ultra-small Gd 2 o 3 Preparation of nanoparticles: using high temperature "polyol" method, using diethylene glycol DEG as solvent and complexing agent, sodium hydroxide NaOH as hydrolyzing agent, and gadolinium chloride hexahydrate GdCl 3 ·6H 2 O reaction, in which the molar ratio of sodium hydroxide to gadolinium chloride is 1-2:1, and the synthesis of ultra-small Gd with a particle size of less than 10nm 2 o 3 Nanoparticles.

[0045] 2mmol GdCl 3 ·6H 2 O was dissolved in 10mL of diethylene glycol, the concentration of gadolinium chloride was 0.2mol / L, and the dissolution temperature was 140°C, 2.5mmol of sodium hydroxide was dissolved in diethylene glycol, the concentration of sodium hydroxide was 0.25mol / L, and the chlorine The gadolinium diethylene glycol solution and the sodium hydroxide diet...

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Abstract

The invention relates to preparation and application of a Gd2O3 nanoparticle controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography and provides a preparation method and application of such an MRI contrast agent, belonging to the fields of bioimaging technology and nanomedical technology. According to the invention, controllable bionic surface modification of an ultra small Gd2O3 nanoparticle by dopamine is carried out by imitating attachment proteins of marine mussels, employing the property of strong chelating action of dopamine on metal ions and utilizing a certain-strength binding force on metals produced by the strong anchoring effect of an o-dihydroxybenzene group, and thus, the Gd2O3 contrast agent--DA-Gd2O3Gd2O3 / DA which is controllably surface-modified by dopamine and used for positive reinforcement of MRI radiography is obtained. The Gd2O3 contrast agent provided by the invention has an obvious contrast reinforcing effect, can improve intensity of magnetic resonance signals and brighten the image of a related position and is applicable as a contrast agent for MRI T1-weighted positive reinforcement.

Description

technical field [0001] The invention belongs to the field of biomedical imaging technology and nanomedicine technology, relates to nuclear magnetic resonance imaging (Magnetic resonance imaging, MRI) imaging technology, in particular to a Gd that can be used for MRI imaging to positively enhance the controllable modification of the surface of dopamine 2 o 3 Nanoparticle preparation methods are provided as T 1 Novel biomaterials for weighted positive contrast agents. Background technique [0002] Magnetic resonance imaging (MRI) belongs to biological spin imaging technology, which has the advantages of no radiation damage, high spatial resolution, three-dimensional visualization and long-term imaging. As a new medical non-destructive imaging diagnostic technology in clinical diagnosis, MRI is widely used in imaging various parts of the human body. It is used to check various diseases in various parts of the human body, and can even check tissue necrosis, local ischemia and ...

Claims

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Application Information

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IPC IPC(8): A61K49/06B82Y30/00
Inventor 徐海波黄海涛郝晶范文亮黄进
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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