Compound paracetamol and amantadine hydrochloride capsule and preparation method thereof

A compound paracetamol and capsule technology, applied in the field of medicine, can solve the problems of low bioavailability of the human body, unsatisfactory drug disintegration, poor drug stability, etc., and achieves unaffected therapeutic efficacy, small weight difference, and drug resistance. Ingredient stabilization effect

Active Publication Date: 2014-07-23
SHANDONG SBOND PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the deficiencies of the prior art, the present invention provides a compound acetaminophen capsule and a preparation method thereof, through innovative selection of excipients and optimized proportion of excipients, successfully solving the problem of unsatisfactory drug disintegration, low drug dissolution rate, and poor drug stability. , Human bioavailability is not high, etc.

Method used

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  • Compound paracetamol and amantadine hydrochloride capsule and preparation method thereof
  • Compound paracetamol and amantadine hydrochloride capsule and preparation method thereof
  • Compound paracetamol and amantadine hydrochloride capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] The preparation of embodiment 1 compound acetaminophen capsules:

[0090] Compound paracetamol capsules are made from the following raw materials in parts by mass:

[0091]

[0092] The preparation method is as follows:

[0093] (1) Paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, crushed through an 80-mesh sieve for later use, artificial bezoar through an 80-mesh sieve for later use, montmorillonite through a 350-mesh sieve; sucrose through a 100-mesh sieve spare;

[0094] (2) Take sucrose and montmorillonite according to the proportioning ratio, first dissolve sucrose in boiling water, then add montmorillonite, stir evenly, and prepare 50g L-1 montmorillonite / sucrose solution for subsequent use;

[0095] (3) Take by weighing paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, artificial bezoar and mix uniformly, then add the montmorillonite / sucrose solution prepared in step (2), stir and mix uniformly to prepare i...

Embodiment 2

[0100] The preparation of embodiment 2 compound acetaminophen capsules:

[0101] Compound paracetamol capsules are made from the following raw materials in parts by mass:

[0102]

[0103]

[0104] The preparation method is as follows:

[0105] (1) Paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, crushed through a 100-mesh sieve for later use, artificial bezoar through a 100-mesh sieve for later use, montmorillonite through a 400-mesh sieve; sucrose through a 110-mesh sieve spare;

[0106] (2) Take sucrose and montmorillonite according to the proportioning ratio, first dissolve sucrose in boiling water, then add montmorillonite, stir evenly, and prepare 50g L-1 montmorillonite / sucrose solution for subsequent use;

[0107] (3) Take by weighing paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, artificial bezoar and mix uniformly, then add the montmorillonite / sucrose solution prepared in step (2), stir and mix uniformly t...

Embodiment 3

[0112] The preparation of embodiment 3 compound acetaminophen capsules:

[0113] Compound paracetamol capsules are made from the following raw materials in parts by mass:

[0114]

[0115] The preparation method is as follows:

[0116] (1) Paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, crushed through a 90-mesh sieve for later use, artificial bezoar through a 90-mesh sieve for later use, montmorillonite through a 375-mesh sieve; sucrose through a 100-mesh sieve spare;

[0117] (2) Take sucrose and montmorillonite according to the proportioning ratio, first dissolve sucrose in boiling water, then add montmorillonite, stir evenly, and prepare 45g L-1 montmorillonite / sucrose solution for subsequent use;

[0118] (3) Take by weighing paracetamol, amantadine hydrochloride, caffeine, chlorpheniramine maleate, artificial bezoar and mix uniformly, then add the montmorillonite / sucrose solution prepared in step (2), stir and mix uniformly to prepare into ...

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Abstract

The invention relates to a compound paracetamol and amantadine hydrochloride capsule and a preparation method thereof. The compound paracetamol and amantadine hydrochloride capsule disclosed by the invention is prepared from the following raw materials in parts by mass: 250-400 parts of paracetamol, 100-160 parts of amantadine hydrochloride, 10-16 parts of calculus bovis factitius, 15-24 parts of caffeine, 2-3.2 parts of chlorpheniramine maleate, 5-30 parts of montmorillonite, and 6-36 parts of cane sugar. By means of innovative accessory selection and optimized accessory proportion, the capsule dosage form is prepared; the problems of being poor in liquidity, non-ideal in drug disintegration, low in drug dissolution rate, poor in stability, not high in human bioavailability and the like in existing drug particles are solved.

Description

technical field [0001] The invention relates to a compound aminophenamine capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The common cold is one of the most common diseases in the world. The causes of colds are mostly caused by colds and viral infections. There are more than 200 viruses that can cause colds, including rhinovirus (the most common cause), coronavirus, adenovirus, and respiratory syndrome. cell thin virus, and parainfluenza virus. Cold is a disease that cannot be ignored, and it is one of the major public health problems faced by human beings. According to statistics, the annual incidence of common cold is 10-30%, and tens of thousands of people are infected every year all over the world. Almost everyone has personal experience. Almost no one has never had a cold in his life. The symptoms are: nasal congestion, runny nose, sneezing, coughing, fever, and body aches. The course of the diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K47/04A61K47/26A61K9/48A61P11/00A61P31/12A61K31/4402A61K31/13A61K31/167A61K31/522
Inventor 乔敏杨毅娟刘钢李红新邵兰兰孟震晓
Owner SHANDONG SBOND PHARMA
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