Flexible Biodegradable Composites
A composite material and biological technology, applied in medical science, surgery, etc., can solve problems such as poor compatibility, loss, and inability of materials to have both flexibility and strength, and achieve the effect of good flexibility
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Embodiment 1
[0028] Preparation of softener:
[0029] In a 100 milliliter reaction vessel equipped with a magnetic stirrer, add a total of 50 grams of polyethylene glycol and lactide with a molecular weight of 6000 in different proportions, and then inject 0.5 milliliters of stannous octoate solution (concentration is 0.1 g / ml).
[0030] The reaction system was decompressed and evacuated at room temperature, and the system was replaced with high-purity nitrogen every half an hour, and so repeated several times. Polymerization was carried out for 12 hours in an oil bath at 150°C with stirring. After the reaction, the obtained polymer was dissolved in dichloromethane, and then precipitated with a large amount of frozen ether, purified and dried in a vacuum oven at 70°C for 24 hours. The feed ratio and molecular weight of the obtained copolymer are shown in Table 1.
[0031] Table 1 Composition and molecular weight of polylactic acid-polyethylene glycol softener
[0032]
[0033] The m...
Embodiment 2
[0038] The preparation of softener is as shown in Example 1.
[0039] The matrix polymer polylactic acid-polyethylene glycol copolymer (molecular weight is 120,000, wherein the polyethylene glycol content is 5wt%) and the prepared softener are mixed in a certain proportion to obtain a flexible biodegradable composite material. As a solvent, the flexible biodegradable composite material is dissolved and the medical anti-adhesion film is prepared by the solution evaporation method, and the thickness of the film is controlled at about 0.1 mm. Through the tensile test, the tensile properties of the film are measured under the condition of 10 mm / min; through the degradation test, the degradation time for the material to maintain a certain strength (greater than 0.5 MPa) is determined. The performance data of the blended membranes are shown in Table 3 below.
[0040]Table 3 matrix polymer is the performance of the medical anti-adhesion film of polylactic acid-polyethylene glycol co...
Embodiment 3
[0044] The preparation of softener is as shown in Example 1.
[0045] The matrix polymer poly(lactic acid-glycolic acid) copolymer (molecular weight is 150,000, wherein the glycolic acid content is 5wt%) and the softener are mixed in a certain proportion to prepare a flexible biodegradable composite material, using chloroform as a solvent, and The flexible biodegradable composite material is dissolved and the medical anti-adhesion film is prepared by the solution volatilization method, and the thickness of the film is controlled at about 0.1 mm. Through the tensile test, the tensile properties of the medical anti-adhesion film are measured under the condition of 10 mm / min; through the degradation test, the degradation time for the material to maintain a certain strength (greater than 0.5 MPa) is determined. The performance data of the medical anti-adhesion film is shown in Table 4 below.
[0046] Table 4 matrix polymer is the performance of the medical anti-adhesion film of p...
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