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Preparation method of surface porous calcium phosphate ceramic material

A bioceramic material, surface porous technology, applied in medical science, prosthesis, etc., can solve the problems of poor controllability of pores, low load-bearing capacity, low purity of porous calcium phosphate bioceramics, etc., to promote the formation of new bone and maintain support. effect of action

Inactive Publication Date: 2015-06-24
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above-mentioned prior art, in order to solve the disadvantages of porous calcium phosphate bioceramics caused by the existing preparation technology, such as reduced purity, low bearing capacity, and poor pore controllability, the present invention provides a method for preparing a surface porous calcium phosphate bioceramic material, It has the advantages of simple process, high phase purity, good controllability of phase composition and pores, and good mechanical properties.

Method used

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  • Preparation method of surface porous calcium phosphate ceramic material
  • Preparation method of surface porous calcium phosphate ceramic material
  • Preparation method of surface porous calcium phosphate ceramic material

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A preparation method of a superficially porous calcium phosphate bioceramic material is realized by the following steps:

[0026] (1) HA powder is prepared by chemical precipitation method, namely ω ACP =0wt%;

[0027] (2) loading the granulated HA powder into the molding die, and compacting under the condition that the pressure is 300MPa and the holding time is 3min;

[0028] (3) heating the compacted green body to 1150°C, holding it for 2 hours, and naturally cooling it in a sintering furnace to obtain dense HA bioceramics;

[0029] (4) The dense HA bioceramic was soaked in Tris-HCl buffer at a solid-to-liquid ratio of 10:1 for 28 days to obtain a superficially porous HA bioceramic with a pore size of 1-6 μm. The longer the soaking time, the larger the pore size, and vice versa. The same is true.

Embodiment 2

[0031] A preparation method of a superficially porous calcium phosphate bioceramic material is realized by the following steps:

[0032] (1) ACP and HA were prepared by chemical precipitation method, and mixed according to ACP:HA ratio of 1:3 to obtain ω ACP = 25 wt% ACP / HA mixed powder;

[0033] (2) packing the ACP / HA composite powder after granulation into the molding die, and compacting under the condition that the pressure is 300MPa and the holding time is 3min;

[0034] (3) heating the compacted green body to 1150°C, holding it for 2 hours, and naturally cooling it in a sintering furnace to obtain a dense β-TCP / HA bioceramic, in which β-TCP accounts for about 25wt%;

[0035] (4) The dense β-TCP / HA bioceramic was soaked in Tris-HCl buffer at a solid-to-liquid ratio of 10:1 for 28 days to obtain a superficially porous β-TCP / HA bioceramic with a pore size of 1-6 μm, and the soaking time The longer it is, the larger the aperture and vice versa.

Embodiment 3

[0037] A preparation method of a superficially porous calcium phosphate bioceramic material is realized by the following steps:

[0038] (1) ACP and HA were prepared by chemical precipitation method, and mixed according to ACP:HA ratio of 1:1 to obtain ω ACP =50wt% ACP / HA composite powder;

[0039] (2) packing the ACP / HA composite powder after granulation into the molding die, and compacting under the condition that the pressure is 300MPa and the holding time is 3min;

[0040] (3) The compacted green body is heated to 1150°C, kept for 2 hours, and then naturally cooled in a sintering furnace to obtain dense β-TCP / HA bioceramics, in which β-TCP accounts for about 50wt%;

[0041] (4) The dense β-TCP / HA bioceramic was soaked in Tris-HCl buffer at a solid-to-liquid ratio of 10:1 for 28 days to obtain a superficially porous β-TCP / HA bioceramic with a pore size of 1-6 μm, and the soaking time The longer it is, the larger the aperture and vice versa.

[0042] The scanning electron...

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Abstract

The invention discloses a preparation method of surface porous calcium phosphate ceramic material. The method comprises the steps of preparing amorphous calcium phosphate (ACP) and hydroxyapatite (HA) by taking calcium salt, such as Ca(NO3)2.4H2O and the like, and microcosmic salt, such as (NH4)2HPO4 and the like, as raw material, mixing the calcium phosphate (ACP) and the hydroxyapatite (HA), so as to obtain ACP / HA composite powder, performing granulation on the composite powder, putting the composite powder into a die to compact the composite powder, with the pressure intensity being 200 to 300MPa and the pressure dwell time being 1 to 5min, then taking out a compacted blank, rising the temperature of the compacted blank to 1100 to 1200 DEG C, sintering the blank, with the holding time being 1 to 2h, ensuring that the blank is naturally cooled to the room temperature in sintering equipment, obtaining dense Beta-TCP / HA two-phase calcium phosphate (BCP) ceramic, and soaking the BCP ceramic formed by sintering into Tris-HCI buffer solution with the concentration being 0.1mol / L and pH value being 7.4 for different time according to the solid-to-liquid ratio being 10:1, so as to obtain surface porous calcium phosphate ceramic with different porosity characters. Beta-TCP, Beta-TCP / HA and HA surface porous biological ceramic with the porosity size being 1 to 6 micrometers can be obtained when the soaking time is 7 to 28 days.

Description

technical field [0001] The invention relates to a preparation method of a bioceramic, in particular to a preparation method of a surface porous calcium phosphate bioceramic material. Background technique [0002] Bone repair materials must meet the basic requirements of biosafety, suitable degradation rate, good mechanical properties, and surface compatibility. Calcium phosphate-based bioceramic materials are widely used in hard tissue repair and reconstruction, and have broad application prospects. When the calcium phosphate-based bioceramic material has a porous (pore size 1-10 μm) structure on the surface, it is more conducive to cell adhesion, proliferation and osseointegration in the early stage of the implant. [0003] At present, there are two main methods for preparing porous bioceramic materials: one is to add fillers (paraffin and other particles) or pore-forming agents (such as hydrogen peroxide) to ceramic powder, and then sinter at high temperature to form porou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40
Inventor 吕宇鹏胡晓霞肖桂勇
Owner SHANDONG UNIV
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