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Method for testing fluoroquinolones antibiotics in cosmetics

A technology for fluoroquinolones and a determination method, which is applied in the field of antibiotic determination, can solve problems such as adverse reactions in the central nervous system and gastrointestinal tract, and achieves good ligand stability and chromatographic reproducibility, high ionization efficiency and reliability. The effect of sensitivity

Active Publication Date: 2014-08-06
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
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  • Claims
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Problems solved by technology

Adding this type of drug to acne cosmetics can significantly improve the effect of acne removal, but it can cause adverse reactions to the central nervous system and gastrointestinal tract, and once the bacteria in acne become resistant to it, it will cause serious consequences

Method used

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  • Method for testing fluoroquinolones antibiotics in cosmetics
  • Method for testing fluoroquinolones antibiotics in cosmetics
  • Method for testing fluoroquinolones antibiotics in cosmetics

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Embodiment 1

[0037] 1. Instruments, reagents and materials

[0038] ACQUITY liquid chromatograph, XEVO TQ triple quadrupole mass spectrometer, MassLynx data processing system (Waters, USA); electronic balance (AB204-S, METTLER TOLEDO, USA); ultrapure water device (Milli-Q, Millipore, USA) ); high-speed refrigerated centrifuge (CR21G, Japan Hitachi company); MS2 type vortex oscillator (Germany IKA company); solid phase extraction device (U.S. SUPELCO company); chromatographic column Waters XBridge C 18 (3.5μm, 2.1mm×150mm, Waters, USA); Mixed solid-phase extraction column (Oasis MCX3mL / 60mg, Waters, USA); Ultrasonic cleaner (KQ-600, Kunshan Ultrasonic Instrument Co., Ltd., Jiangsu Province); Nitrogen blowing instrument (N-EVAP112, Organomation, USA); fume hood (FC-150, Dalian Labtech Laboratory Equipment Co., Ltd.); microporous membrane (0.22 μm, organic system, Pall Corporation, USA).

[0039] Mabaofloxacin (CAS number: 11150-35-1, purity 97.5%), lomefloxacin hydrochloride (CAS number: 98...

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Abstract

The invention discloses a method for testing fluoroquinolones antibiotics in cosmetics. The method comprises the following steps: (1) preprocessing a sample: performing vortex oscillation and ultrasonic extraction on the sample by using a 2% formic acid solution and acetonitrile as solvents according to the volume ratio of 2:1, and performing centrifugal treatment and Water Oasis MCM mixed type solid-phase extraction small column purification on an extracting solution so as to obtain a purified solution; (2) testing the purified solution through a machine, and performing a qualitative and quantitative analysis on the target substance by adopting a liquid chromatogram-mass spectrum / mass spectrum method. The method for testing fluoroquinolones antibiotics in the cosmetics is accurate, high in stability, reliable, and high in sensitivity.

Description

technical field [0001] The invention relates to a method for determining antibiotics, in particular to a method for determining fluoroquinolone antibiotics in cosmetics. Background technique [0002] Fluoroquinolone antibiotics, also known as pyruvate or pyridone acid, are synthetic antibacterial drugs containing 4-quinolone nuclei, and belong to a large class of antibiotics. Since the discovery of the first fluoroquinolone drug nalidixic acid (narrow antibacterial spectrum, abandoned) in the United States in 1962, the development process can be roughly divided into four stages. So far tens of thousands of fluoroquinolone derivatives have been synthesized . Because of its wide antibacterial spectrum, convenient administration, strong activity and low price, it is widely used in the treatment of various infectious diseases. Adding this type of drug to acne cosmetics can significantly improve the effect of acne removal, but it can cause adverse reactions to the central nervo...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 马强孟宪双白桦张庆陈云霞李晶瑞马会娟王元成
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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