Non-contact direct-current induction electrospray ionization device and method

Abstract

The invention discloses a non-contact direct-current induction electrospray ionization device and method. The device comprises an electrode, a high-voltage direct-current power supply and a spray head of a nanoliter electric sprayer. The spray head of the nanoliter electric sprayer and the axis of the long and straight wire electrode are in the same straight line. The spray head is located between the electrode and a mass spectrum sample inlet. Electric field lines generated by the tip of the electrode under the excitation of a high voltage penetrate through a conical liquid dialectic before being gathered, so that the intensity of an electric field at the tip of the spray head is greatly enhanced, and liquid to be measured is subjected to electrospray ionization. By means of the non-contact direct-current induction electrospray ionization device and method, the problem that an existing nanoliter electric sprayer can not achieve direct ionization of several samples at the nanoliter grade is solved; meanwhile, the non-contact direct-current induction electrospray ionization device and method can be used for array analysis of the nanoliter electric sprayer. The device is simple in structure, convenient to manufacture and capable of being obtained just by conducting a simple mechanical improvement on the basis of an ion source of a traditional nanoliter electric sprayer; the device can be coupled with an existing commercial mass spectrum instrument, so that the practicability is high; moreover, a lot of problems existing in traditional nanoliter electric sprayers are solved, and the device has wide application prospect and high economic value.

Description

technical field [0001] The invention relates to an electrospray mass spectrometer ionization device and an ionization method, in particular to a non-contact DC induction electrospray ionization device and an ionization method. Background technique [0002] Organic mass spectrometry is an analytical method widely used in the field of life science research that can achieve qualitative, quantitative and structural analysis. Electrospray ionization (ESI) and laser-assisted desorption ionization (MALDI) are the two most typical and widely used ionization methods for organic mass spectrometers. The classic ESI ionization process is described below. The sample solution enters through one section of the capillary, and forms a charged aerosol under the combined action of a strong electric field and sheath gas from the other section. The charge density of the aerosol gradually increases through the solvent volatilization process, resulting in a Coulomb explosion, which eventually io...

AI Technical Summary

Problems solved by technology

However, the electrical contact problem in NSI limits the use of electrospray technology: 1. The electrode contacts with the spray solution to produce an electrochemical reaction, which affects the measurement; 2. When measuring nanoliter or even picoliter small volume liquid, the electrospray Access is very difficult; 3. Array analysis using NSI is very difficult; 4. The throughput of NSI analysis is low

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