Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of citric acid grafted chitosan hydrogel

A technology of citric acid and chitosan, which is applied in the field of preparation of citric acid-grafted chitosan hydrogel, can solve the problems of increasing dispersion, affecting the strength of chitosan materials, and decreasing molecular weight, etc., achieving high mechanical strength, Considering the effect of biocompatibility and high mechanical strength

Inactive Publication Date: 2014-08-20
DONGHUA UNIV
View PDF3 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the acid solvent system will cause the degradation of chitosan, resulting in a decrease in molecular weight and an increase in dispersibility, which will seriously affect the strength of the prepared chitosan material.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of citric acid grafted chitosan hydrogel
  • Preparation method of citric acid grafted chitosan hydrogel
  • Preparation method of citric acid grafted chitosan hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] At room temperature, weigh 0.1g chitosan and 0.2g citric acid and disperse in 10g ethanol, then react under magnetic stirring at room temperature 25°C for 4h, centrifuge the product after the reaction, then dissolve it in distilled water and add absolute ethanol Settling and washing 3 times until the pH of the solution=4 is constant, and the precipitate is dried at a constant temperature at 55° C. to constant weight to obtain citric acid grafted chitosan (such as figure 1 , the carbonyl peak in the amide bond appeared in the infrared spectrum of citric acid grafted chitosan, indicating that the chemical grafting was successful). Weigh 0.1g of citric acid-grafted chitosan and dissolve it in 10g of distilled water, take a small amount of the solution into a mold, and then freeze it in a -20°C refrigerator for 12h to form a jelly. The jelly was melted with 0.5M NaOH solution at room temperature for 4 h, and then the gel was washed with distilled water until neutral to obt...

Embodiment 2

[0028] At room temperature, weigh 0.1g of chitosan and 0.2g of citric acid and disperse them in 10g of ethanol, then react at 37°C for 4h under magnetic stirring. Analysis and washing were performed for 3 times until the pH = 4, and the precipitate was dried at a constant temperature at 55° C. to a constant weight to obtain citric acid grafted chitosan. Weigh 0.2g of citric acid-grafted chitosan and dissolve it in 10g of distilled water, take a small amount of the solution into a mold, and then freeze it in a -20°C refrigerator for 12h to form a jelly. The jelly was melted with 0.5M NaOH solution at room temperature for 4 h, and then the gel was washed with distilled water until neutral to obtain a high-strength citric acid grafted chitosan hydrogel ( figure 2 b). When the compression ratio is 30%, its compressive strength is 0.13MPa ( image 3 b).

Embodiment 3

[0030] At room temperature, weigh 0.1g of chitosan and 0.2g of citric acid and disperse them in 10g of ethanol, then react at 50°C for 4h under magnetic stirring. After analysis and washing for 3 times until the solution pH=4, the precipitate was dried at a constant temperature at 55° C. to a constant weight to obtain citric acid grafted chitosan. Weigh 0.3g of citric acid-grafted chitosan and dissolve it in 10g of distilled water, take a small amount of the solution into a mold, and then freeze it in a -20°C refrigerator for 12h to form a jelly. The jelly was melted with 0.5M NaOH solution at room temperature for 4 h, and then the gel was washed with distilled water until neutral to obtain a high-strength citric acid grafted chitosan hydrogel ( figure 2 c). When the compression ratio is 30%, its compressive strength is 0.20MPa ( image 3 c).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
compressive strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a citric acid grafted chitosan hydrogel. The preparation method comprises the following steps: reacting the chitosan and the citric acid in an ethanol medium to prepare the citric acid grafted chitosan, then dissolving the prepared citric acid grafted chitosan in water and freezing; then melting the frozen citric acid grafted chitosan by virtue of alkaline solution treatment and washing by using water until the solution is neutral, thereby obtaining a high-strength citric acid grafted chitosan hydrogel. The chitosan can be dissolved in water after being grafted with the citric acid, so that the adverse effect caused by acidic dissolution is avoided; according to the preparation method, a gel formation method of forming jelly by virtue of freezing and alkali-heat-treatment is adopted, so that porous chitosan based hydrogels of different shapes can be prepared quickly; the prepared chitosan based hydrogels are high in mechanical strength; when the compression ratio is 30%, the maximum compression strength can be 0.23MPa; in addition, the biocompatibility of the chitosan is effectively taken into account.

Description

technical field [0001] The invention belongs to the field of hydrogel preparation, in particular to a preparation method of citric acid grafted chitosan hydrogel. Background technique [0002] Chitosan, as the second largest natural polymer material except cellulose, is the only biorenewable alkaline polysaccharide polymer obtained from chitin by deacetylation. Chitosan has the characteristics of rich sources, good biocompatibility, biodegradability, drug activity, antitumor activity and antibacterial properties, and is widely favored in the fields of food industry, textile industry, environmental protection, medicine and health care, etc. The further development and application of polysaccharide materials is of great significance. [0003] Hydrogel is a kind of hydrophilic three-dimensional network polymer. After absorbing water, its weight can reach tens to hundreds of times its own weight. It is insoluble in water itself and can maintain its shape and characteristics in ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/075C08L5/08C08B37/08
Inventor 张彦中袁卉华李碧云娄向新赵庆华
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com