Implant prosthesis and manufacturing method thereof

A technology for implanting prostheses and prostheses, applied in the field of prostheses, can solve the problems of high processing costs and cumbersome operation steps, and achieve the effect of non-sensitization, simple operation steps, and obvious cytotoxicity

Inactive Publication Date: 2014-09-10
CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The plasma surface modification method is to expose the inert implant material to non-polymerizable gas plasma, and use the plasma to bombard the surface of the material to cause changes in the surface structure of the inert implant material, thereby increasing the biocompatibility of the surface. This method requires the use of a plasma generator, which is expensive to process
The surface graft copolymerization method is to graft and copolymerize hydrophilic substances to the surface of inert implant materials in the form of chemical bond cross-linking. This method can effectively improve the biocompatibility of inert implant materials, but the operation steps are relatively cumbersome.

Method used

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  • Implant prosthesis and manufacturing method thereof
  • Implant prosthesis and manufacturing method thereof
  • Implant prosthesis and manufacturing method thereof

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preparation example Construction

[0032] The invention also discloses a preparation method for the implanted prosthesis, comprising:

[0033] Coating a surface modifier on the surface of the inert implant material and drying it to obtain the implant prosthesis;

[0034] The surface modifiers include water, dispersants and bioceramic materials.

[0035] In the present invention, a surface modifier is first coated on the surface of the inert implant material, which refers to a biomedical material that can remain stable in a biological environment and does not or only weakly react, including but Not limited to silicone rubber, polyethylene, polyvinyl chloride, acrylic, PTFE, polyacrylamide or polyurethane. In the present invention, there is no special limitation on the source of the inert implant material, which can be purchased commercially. There is no special limitation on the shape of the inert implant material, and it can be trimmed into a desired shape according to the actual situation. In the present in...

Embodiment 1

[0045] 4 parts by mass of sodium carboxymethyl cellulose was added to 94 parts by mass of pure water and stirred evenly, and then 2 parts by mass of nanoscale hydroxyapatite powder was added and stirred evenly to obtain a surface modifier.

[0046] Sterilize the obtained surface modifier, and put it into a hand-held pressure spray can after sterilization.

[0047] Trim the silicone rubber into a desired shape, then spray the surface modifier on the surface of the silicone rubber, and let it dry for 10 minutes to obtain an implanted prosthesis.

[0048] Biocompatibility testing of the above implanted prostheses

[0049] Sampling from the above implanted prosthesis, the sampling size is 0.2mm × 1cm × 1cm, the sampling sample is used as the experimental group, the polylysine-coated glass slide and pure silicone rubber are used as the control group, and the experimental group and the control group are used as the control group. After sterilization, the groups were placed in 24-we...

Embodiment 2

[0084] 1 part by mass of sodium carboxymethyl cellulose was added to 94 parts by mass of pure water and stirred evenly, and then 5 parts by mass of nanoscale hydroxyapatite powder was added and stirred evenly to obtain a surface modifier.

[0085] Sterilize the obtained surface modifier, and put it into a hand-held pressure spray can after sterilization.

[0086] Trim the silicone rubber into a desired shape, then spray the surface modifier on the surface of the silicone rubber, and let it dry for 15 minutes to obtain an implanted prosthesis.

[0087] The biocompatibility test of the above implanted prosthesis shows that the above implanted prosthesis has good biocompatibility, and the growth and differentiation of cells on the surface of the above implanted prosthesis is obviously better than that of pure silicone rubber material.

[0088] The biosafety test of the above implanted prosthesis shows that the hemolysis rate of the above implanted prosthesis is lower than 5%, and...

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Abstract

The invention provides implant prosthesis and a manufacturing method thereof. The implant prosthesis provided by the invention is compounded with a biological ceramic material on the surface of an inert implant material; the biological ceramic material can show good affinity with biological tissues such as cells, and therefore, the implant prosthesis has high biocompatibility, and a problem that the existing inert implant material is not compatible with the human body is solved. Meanwhile, the biological ceramic material of the implant prosthesis is compounded to the inert implant material, so that an internal structure of the inert implant material is not damaged, and therefore, decline in physical and chemical performances of the inert implant material are not caused. Experiment results indicate that the implant prosthesis prepared by the method disclosed by the invention is good in biocompatibility, free of sensitization and obvious cell toxicity.

Description

technical field [0001] The invention belongs to the field of prostheses, in particular to an implanted prosthesis and a manufacturing method thereof. Background technique [0002] Medical plastic surgery is the repair and reconstruction of congenital or acquired tissue defects and deformities of the human body through surgical operations. The most common medical plastic surgery method is to implant silicone rubber, acrylic resin, polyacrylamide and other inert implant materials into the human body as tissue substitutes to repair tissue defects or deformities caused by various reasons, so as to improve or restore their physiological functions and appearance. [0003] Due to the stable chemical properties of silicone rubber, acrylic resin, polyacrylamide and other inert implant materials, they are not easy to degrade, which makes them incompatible with human tissues after implantation, which leads to the common complication of prosthesis implantation—capsular contracture. Ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/16A61L27/18
Inventor 王科
Owner CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
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