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Aspirin enteric sustained-release capsule and preparation method thereof

A technology of aspirin and sustained-release capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of gastric mucosal irritation, inconvenience, gastric bleeding, etc., and achieve the effect of avoiding irritation

Inactive Publication Date: 2014-10-01
HEFEI JINYUE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aspirin has a strong stimulating effect on the gastric mucosa, and long-term high-dose use can cause gastric ulcers and gastric bleeding
In addition, the half-life of aspirin is only 15 minutes. For patients with cardiovascular diseases who need to take medicine for a long time, it is very inconvenient to take multiple doses every day.

Method used

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  • Aspirin enteric sustained-release capsule and preparation method thereof
  • Aspirin enteric sustained-release capsule and preparation method thereof
  • Aspirin enteric sustained-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation method: sieve aspirin, hydroxypropyl methylcellulose, sodium carboxymethyl starch, and starch respectively, dry mix for 10 minutes, add binder povidone ethanol solution to make soft material, granulate, dry, and granulate , add magnesium stearate, mix evenly, press into microtablets, fill, and obtain.

Embodiment 2

[0026]

[0027] Preparation method: sieve aspirin, hydroxypropyl methylcellulose, sodium carboxymethyl starch, pregelatinized starch and microcrystalline cellulose respectively, dry mix for 20 minutes, add magnesium stearate to mix evenly, and directly press into microcrystalline cellulose Tablets, filling, ready to serve.

Embodiment 3

[0029]

[0030] Preparation method: sieve aspirin, hydroxypropyl methylcellulose, sodium carboxymethyl starch, and dextrin respectively, dry mix for 10 minutes, add the binder povidone ethanol solution to make a soft material, granulate, dry, and prepare Granules, mixed with magnesium stearate evenly, pressed into microtablets, filled, and obtained.

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PUM

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Abstract

The invention provides an aspirin enteric sustained-release capsule and a preparation method thereof, and relates to the technical field of medicament production. The formula of the capsule comprises the following components: 30-60 percent of aspirin, 30-60 percent of packing, 1-10 percent of release regulating agent and 2-20 percent of a frame material, wherein the packing is one or more of mannitol, sorbitol, xylitol, lactose, saccharose, glucose, starch, dextrin, pregelatinized starch and microcrystalline cellulose; the release regulating agent is one or more of sodium carboxymethyl starch, polyvinylpolypyrrolidone, hydroxypropylcellulose and microcrystalline cellulose; the frame material is one or more of hydroxypropyl methyl cellulose, ethyecellulose, carbomer, sodium alginate and stearic acid. About 100mg of the aspirin enteric sustained-release capsule is taken once a day conventionally, irritation of the capsule to gastric mucosa is avoided due to existence of the enteric capsule after a patient takes the aspirin enteric sustained-release capsule, the capsule is dissolved after entering the intestinal tract, and the content micro-tablet of the capsule slowly release aspirin, so that the aspirin enteric sustained-release capsule is very convenient for patients who have cardiovascular diseases and need to take medicines for a long time.

Description

technical field [0001] The invention relates to the technical field of medicament production, in particular to an aspirin enteric-coated sustained-release capsule and a preparation method thereof. Background technique [0002] Aspirin, also known as acetylsalicylic acid, is a non-steroidal anti-inflammatory drug. As the earliest synthetic non-selective cyclooxygenase inhibitor, aspirin is mainly used to treat colds, fever, headache, rheumatism, etc. It has been clinically used for more than 100 years, and aspirin is still the most widely used antipyretic analgesic. pain medicine. In recent years, with the deepening of research, the field of clinical application of aspirin has been continuously expanded, including the prevention and treatment of cardiovascular and cerebrovascular diseases and the prevention of cancer. For example, taking large doses can reduce inflammation, taking medium doses can relieve pain, taking small doses can prevent blood vessel blockage caused by ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/616A61K47/38A61P29/00A61P11/00A61P9/00A61P9/10A61P35/00
Inventor 刘延武王晓华朱玉王超群
Owner HEFEI JINYUE PHARMA
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