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Oral preparation for analgesia, and preparation method of oral preparation

A technology for oral preparations and compositions, applied in the field of oral preparations and their preparation, can solve the problems of seriousness, addiction, gastrointestinal reactions, etc., and achieve the effects of reducing dosage, reducing toxic side effects, and improving stability

Active Publication Date: 2014-10-15
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of NSAIDs and opioids can cause severe gastrointestinal reactions and addiction

Method used

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  • Oral preparation for analgesia, and preparation method of oral preparation
  • Oral preparation for analgesia, and preparation method of oral preparation
  • Oral preparation for analgesia, and preparation method of oral preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Effect of pharmaceutical composition on mouse writhing times caused by acetic acid

[0028] Male ICR mice (20±2) g were randomly divided into groups according to body weight, 10 mice in each group, and each group was given therapeutic drugs by intragastric administration. The model group was intragastrically given an equal volume of normal saline. Intraperitoneal injection of acetic acid in mice caused large-scale and long-lasting pain stimulation in the deep abdominal cavity, resulting in writhing reactions in mice. After each dose group was administered for 1 hour, 0.1ml / 10g of 0.7% acetic acid saline solution was injected intraperitoneally, and the number of writhing reactions in each mouse within 20 minutes after the injection of acetic acid induced pain was recorded, and the writhing times of each administration group were calculated. Inhibition rate.

[0029] Writhing inhibition rate=[(the number of times of writhing in the control group-the number of ...

Embodiment 2

[0035] Example 2 Effect of pharmaceutical composition on hot plate-induced pain response in mice

[0036] Put female ICR mice (20±2) g on an intelligent hot plate instrument at 55±0.5°C, record the latency (s) from when the sole of the mouse touches the hot plate to the reaction of licking the rear paw as the pain threshold index, and remove the reaction Mice with latency 30s or jumping. Select 140 qualified mice with response latency within 10-30s, randomly group them into groups according to predrug pain threshold and body weight, and administer them by intragastric administration;

[0037] Model group: equal volume of saline,

[0038] Composition group: 50mg / kg, ig

[0039] After continuous intragastric administration for 5 days, the pain threshold of the mice in each administration group was measured once 30, 60, 90, and 120 minutes after the last administration, and the pain threshold exceeding 60s was calculated as 60s.

[0040] data to Said, using SPSS15.0 software...

Embodiment 3

[0044] Example 3 Tablet

[0045] prescription

[0046]

[0047] Preparation process: 1) Grinding the pharmaceutical composition and auxiliary materials through an 80-mesh sieve, fully mixing the pharmaceutical composition, methylcellulose and mannitol, 2) 50% ethanol soft material, granulating through a 18-mesh sieve, 60°C Dry it under a 16-mesh sieve, granulate it, add micropowder silica gel, mix evenly, and press it into tablets to get final product. The weight of the tablet is 400 mg, and the proportion of the pharmaceutical composition is that of the administration group 2 in Example 1.

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PUM

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Abstract

The invention relates to the field of medicines, in particular to an oral preparation for analgesia, and a preparation method of the oral preparation. The oral preparation comprises a medicine composition and auxiliary materials, wherein the medicine composition comprises rosmarinic acid, tetrahydropalmatine, mangiferin and diclofenac sodium at a weight ratio of (2-4):(5-8):(3-6):(2-4); the auxiliary materials are preferably methyl cellulose, mannitol, aerosil and aspartame at a weight ratio of (200-400):(30-80):(30-60):(1-3); and a weight ratio of the medicine composition to the auxiliary materials is 1:(15-30).

Description

technical field [0001] The invention relates to the field of medicines, in particular to an oral preparation for analgesia and a preparation method thereof. Background technique [0002] Pain is a protective mechanism that alerts the body to the need for medical help. However, the loss of protective meaning of chronic pain has a heavy impact on people's lives. Clinically, at least half of the patients seek medical treatment because of pain. Existing analgesics are either ineffective, prone to serious adverse reactions, or both. For example, opioids can cause addiction, constipation, and respiratory depression; possible opioid abuse and drug dependence limit the use of these drugs. Non-steroidal anti-inflammatory drugs, COX-2 inhibitors, etc. have poor analgesic effects, and their application is limited because of many fatal and non-fatal adverse reactions. Therefore, it is very necessary and urgent to develop a drug that targets peripheral receptors and has strong analge...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/20A61P29/00A61P25/00A61K31/4375A61K31/196A61K31/352
Inventor 唐玲王姣
Owner DALIAN UNIVERSITY
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