Oral preparation for analgesia, and preparation method of oral preparation

Abstract

The invention relates to the field of medicines, in particular to an oral preparation for analgesia, and a preparation method of the oral preparation. The oral preparation comprises a medicine composition and auxiliary materials, wherein the medicine composition comprises rosmarinic acid, tetrahydropalmatine, mangiferin and diclofenac sodium at a weight ratio of (2-4):(5-8):(3-6):(2-4); the auxiliary materials are preferably methyl cellulose, mannitol, aerosil and aspartame at a weight ratio of (200-400):(30-80):(30-60):(1-3); and a weight ratio of the medicine composition to the auxiliary materials is 1:(15-30).

Description

technical field

[0001] The invention relates to the field of medicines, in particular to an oral preparation for analgesia and a preparation method thereof. Background technique

[0002] Pain is a protective mechanism that alerts the body to the need for medical help. However, the loss of protective meaning of chronic pain has a heavy impact on people's lives. Clinically, at least half of the patients seek medical treatment because of pain. Existing analgesics are either ineffective, prone to serious adverse reactions, or both. For example, opioids can cause addiction, constipation, and respiratory depression; possible opioid abuse and drug dependence limit the use of these drugs. Non-steroidal anti-inflammatory drugs, COX-2 inhibitors, etc. have poor analgesic effects, and their application is limited because of many fatal and non-fatal adverse reactions. Therefore, it is very necessary and urgent to develop a drug that targets peripheral receptors and has strong analge...

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