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A kind of preparation technology of uv controlled-release medicinal ingredient and easy-to-clean pickering emulsion type sunscreen

A medicinal ingredient and preparation technology, applied in the field of sunscreen cosmetics and fine chemical industry, can solve the problems of unavoidable side effects and irritation, lack of drug controlled release ability, affect the stability of emulsion, etc., and achieve the effect of controlled drug release. , Strong sun protection effect, good sun protection effect

Active Publication Date: 2016-08-17
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The higher the concentration of organic sunscreen, the heavier the burden on the skin, TiO 2 If the content increases, it may affect the stability of the emulsion
The preparation process cannot avoid the toxic side effects and irritation of organic additives (surfactants and organic sunscreens). The inside of the sunscreen paste is in the form of micelles, which is difficult to clean after use and basically does not have the ability to control drug release.

Method used

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  • A kind of preparation technology of uv controlled-release medicinal ingredient and easy-to-clean pickering emulsion type sunscreen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step 1: TiO 2 Preparation method of nanoparticle surfactant

[0023] (a) TiO 2 Preparation of nanoparticles: Add 36 mL of absolute ethanol to 9 mL of butyl titanate and keep stirring to obtain a mixed solution A; add 12 mL of deionized water to 40 mL of glacial acetic acid and keep stirring to get a mixed solution B. Add the mixed solution B dropwise to the stirred mixed solution A to prepare a transparent sol (the sol can be doped with N elements to adjust the light response time and intensity). Transfer the transparent sol to a hydrothermal synthesis reaction kettle for a constant temperature reaction at 150°C, the reaction time is 2 hours, remove the supernatant, and obtain white TiO 2 precipitation. Wash the white TiO with absolute ethanol 2 Precipitate, 15000rpm high-speed centrifugation for 10 minutes, repeat the above operation 3 times, discard the supernatant, collect the precipitate, then add absolute ethanol to fully disperse, and dry in an oven at 60°C to...

Embodiment 2

[0030] Step 1: TiO 2 Preparation method of nanoparticle surfactant

[0031] (a) TiO 2 Preparation of nanoparticles: Add 36 mL of absolute ethanol to 9 mL of butyl titanate and keep stirring to obtain a mixed solution A; add 12 mL of deionized water to 40 mL of glacial acetic acid and keep stirring to get a mixed solution B. Add the mixed solution B dropwise to the stirred mixed solution A to obtain a transparent sol. Transfer the transparent sol to a hydrothermal synthesis reaction kettle for a constant temperature reaction at 150°C. The reaction time is 2 hours. Remove the supernatant to obtain white TiO 2 precipitation. Wash the white TiO with absolute ethanol 2 Precipitate, 15000rpm high-speed centrifugation for 10 minutes, repeat the above operation 3 times, discard the supernatant, collect the precipitate, then add absolute ethanol to fully disperse, and dry in an oven at 60°C to obtain relatively pure TiO 2 precipitation. The dried TiO 2 The precipitate was fully ...

Embodiment 3

[0038] The oil phase is replaced with No. 26 white oil of cosmetic grade, and other steps are as described in Example 1 and Example 2.

[0039] After diluting the self-made Pickering emulsion sunscreen and the traditional organic sunscreen to the same multiple, the absorbance was measured respectively. According to the drawn ultraviolet wavelength scanning chart, the self-made Pickering emulsion sunscreen has better sun protection effect than the traditional organic sunscreen. This is due to the TiO in homemade Pickering lotion-based sunscreens 2 Nanoparticles can not only reflect and scatter ultraviolet rays, but also have a strong absorption effect on ultraviolet rays. At the same time, the self-made Pickering emulsion sunscreen and the traditional organic sunscreen were applied to the same carrier in equal doses, and the residues were cleaned after equal time and intensity of light, and the cleaning effect of the self-made Pickering emulsion sunscreen was obvious. The main...

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Abstract

The invention discloses a preparation process of a Pickering emulsion type sunscreen with UV controlled release of medicinal ingredients and easy to clean. UV photoresponsive TiO 2 It is prepared by high-speed homogenization, dispersion and emulsification after blending nanoparticle surfactant, oil phase components and water phase components. First, a TiO stabilized Pickering emulsion was prepared by alkylsilane modification 2 The nanoparticle surfactant is added into the oil phase and mixed with the water phase to emulsify to obtain the target water-in-oil (W / O) emulsion type sunscreen. Nanoparticles have UV photoresponse properties, and after a period of sunlight irradiation, the emulsion can be demulsified and phase-separated and the medicinal ingredients can be released. The method of the invention is simple and convenient, and the obtained product has the characteristics of strong sunscreen effect, light-responsive controlled release of medicinal ingredients, and easy cleaning after a period of sunlight exposure, and has good application prospects in the field of cosmetics industry.

Description

technical field [0001] The invention relates to the field of fine chemicals, especially the field of sunscreen cosmetics. Background technique [0002] Sunscreen is known as the "Summer Skin Protector". It can not only effectively isolate ultraviolet rays and prevent the production of melanin and skin cancer, but also has miraculous effects such as sterilization, freckle removal, whitening, and anti-aging. With the development of society and the enhancement of public awareness of sun protection, the characteristics, application and safety of sunscreens have increasingly become the focus of attention. [0003] In the current daily sunscreens, most of the sunscreens are organic substances such as benzophenone and methoxycinnamate, so they have certain toxic side effects and irritation. 2 It has become a development trend to replace organic sunscreens with inorganic sunscreens such as nanoparticles. Currently contains TiO 2 Nanoparticle sunscreens only utilize TiO 2 Nanopa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/97A61K8/67A61K8/34A61K8/29A61K8/06A61Q17/04
Inventor 孟涛白瑞雪张青郭婷
Owner SOUTHWEST JIAOTONG UNIV
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