Veterinary ciprofloxacin-lincomycin long-acting injection liquid and preparing method thereof

A technology for lincomycin and injection, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. The frequency of medication, the improvement of the treatment effect, the stable effect

Inactive Publication Date: 2014-11-05
XINYANG AGRI & FORESTRY UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Long-acting injection composed of ciprofloxacin and lincomycin hydrochloride has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Veterinary ciprofloxacin-lincomycin long-acting injection liquid and preparing method thereof
  • Veterinary ciprofloxacin-lincomycin long-acting injection liquid and preparing method thereof
  • Veterinary ciprofloxacin-lincomycin long-acting injection liquid and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Weigh 2.0 g of ciprofloxacin, add 30 mL of water for injection, then add 2.0 mL of lactic acid, stir well until it is completely dissolved, and set aside;

[0028] (2) Weigh 2.0 g of lincomycin hydrochloride, add 5.0 mL of water for injection, fully stir until it is completely dissolved, and set aside;

[0029] (3) Weigh polyvinylpyrrolidone (PVP) 40 ) 3.0g, add 20mL of propylene glycol, heat in a water bath at 60-70°C, stir fully until all dissolved, and put it at room temperature for later use;

[0030] (4) Add the solution prepared in step (2) into the solution prepared in step (1) in turn, stir evenly, then add the solvent prepared in step (3), Tween-800.8mL, and add water for injection to 100mL;

[0031] (5) After filtering, filling with nitrogen, and sterilizing with 100 ℃ of steam for 30 minutes, it is the finished product.

Embodiment 2

[0033] (1) Weigh 2.5 g of ciprofloxacin, add 40 mL of water for injection, then add 3 mL of lactic acid, stir well until it is completely dissolved, and set aside;

[0034] (2) Weigh 3.0 g of lincomycin hydrochloride, add 15 mL of water for injection, fully stir until it is completely dissolved, and set aside;

[0035] (3) Weigh polyvinylpyrrolidone (PVP) 40 ) 5.0g, add 30mL of propylene glycol, heat in a water bath at 60-70°C, stir fully until all dissolved, put it at room temperature for later use;

[0036] (4) Add the solution prepared in step (2) into the solution prepared in step (1) in turn, stir evenly, then add the solvent prepared in step (3), Tween-801.5mL, and add water for injection to 100mL;

[0037] (5) After filtering, filling with nitrogen, and sterilizing with 100 ℃ of steam for 30 minutes, it is the finished product.

Embodiment 3

[0039] (1) Weigh 5.0 g of ciprofloxacin, add 50 mL of water for injection, then add 2.5 mL of lactic acid, stir well until it is completely dissolved, and set aside;

[0040] (2) Weigh 5.0 g of lincomycin hydrochloride, add 10 mL of water for injection, fully stir until it is completely dissolved, and set aside;

[0041] (3) Weigh polyvinylpyrrolidone (PVP) 40 ) 4.0g, add 20mL of propylene glycol, heat in a water bath at 60-70°C, stir fully until all dissolved, put it at room temperature for later use;

[0042] (4) Add the solution prepared in step (2) into the solution prepared in step (1) in turn, stir evenly, then add the solvent prepared in step (3), Tween-801mL, and add water for injection to 100mL;

[0043] (5) After filtering, filling with nitrogen, and sterilizing with 100 ℃ of steam for 30 minutes, it is the finished product.

[0044] Pharmacokinetic study of ciprofloxacin-lincomycin long-acting injection in pigs

[0045] 1. Test materials

[0046] 1. Medicines ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a veterinary ciprofloxacin-lincomycin long-acting injection liquid and a preparing method thereof. The injection liquid is a compound preparation of ciprofloxacin and lincomycin hydrochloride. The method comprises the steps: adding ciprofloxacin in the prescription into a proper amount of injection water, adding a proper amount of lactic acid, and stirring to fully dissolve; then adding polyvinylpyrrolidone (PVP40) into a propylene glycol solvent, and heating to dissolve; dissolving lincomycin hydrochloride in injection water, followed by slowly adding the lincomycin hydrochloride aqueous solution into the ciprofloxacin solution, then adding the PVP40-containing propylene glycol solvent and Twain 80, uniformly stirring and mixing, filtering, filling nitrogen gas, carrying out steam flow sterilization, and thus obtaining the veterinary ciprofloxacin-lincomycin long-acting injection liquid. The prepared ciprofloxacin-lincomycin long-acting injection liquid has good stability and controllable quality, has the treatment effect better than single ciprofloxacin and single lincomycin hydrochloride, also has long half-life period, can reduce the number of times of drug administration, reduces drug adverse reactions and animal stress response, improves the treatment effect and efficiency on respiratory diseases of livestock and poultry, and has broad application prospects in veterinary clinic.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and more particularly, the invention relates to a long-acting ciprofloxacin-lincomycin injection for veterinary use and a preparation method thereof. Background technique [0002] In recent years, with the large-scale development of animal husbandry and frequent introduction of breeds between different regions and countries, various diseases, especially respiratory diseases of livestock and poultry, are increasing day by day, which has become a major problem in the production process of livestock and poultry industry. The pathogenic bacteria that cause chronic respiratory diseases and bacterial respiratory diseases in livestock and poultry mainly include Mycoplasma, Haemophilus para, Actinobacillus pleuropneumoniae, Pasteurella, Bordetella bronchiseptica, Salmonella, Streptococcus and so on. There are many different bacterial serotypes and the epidemic background is complex. At present...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K9/08A61K47/34A61P31/04A61K31/496
Inventor 刘锦妮吴海港刘纪成陈培荣刘佳赵云焕李迎晓肖世文
Owner XINYANG AGRI & FORESTRY UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap