Preparation method of HAp blended silver and copper antibacterial composite coating

A technology of composite coating and antibacterial agent, which is applied in the field of preparation of HAp mixed with silver and copper antibacterial agent composite coating, can solve the problems of literature and patent reports that do not use silver and copper antibacterial agent to modify bionic artificial ligament, etc. Achieve the effects of promoting clinical application, improving osseointegration ability, and reducing synovitis

Inactive Publication Date: 2014-11-05
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there are still no literature and patent reports on the modific

Method used

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  • Preparation method of HAp blended silver and copper antibacterial composite coating
  • Preparation method of HAp blended silver and copper antibacterial composite coating
  • Preparation method of HAp blended silver and copper antibacterial composite coating

Examples

Experimental program
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Embodiment 1

[0033] Present embodiment relates to a kind of preparation method of HAp blending silver and copper antibacterial agent composite coating, described method comprises the steps:

[0034] The first step is the pretreatment of the artificial ligament. The surface of the artificial ligament is ultrasonically cleaned for 30 minutes, rubbed repeatedly with steel grit with a surface roughness of 50um for 5 times, rinsed with distilled water for 3 times, and dried in vacuum;

[0035] In the second step, with water as solvent, 1 ml of 25 mmol / L CaSO 4 , Ag source (silver nitrate: silver bromide = 1:1 mixed) and CuSO 4 and 5 ml of 25 mg / L bovine gelatin solution, adjust the pH value to 8, and stir for 5 minutes at 25°C, then soak the artificial ligament in this mixture, and stir for 30 minutes to make the free Ca and Ag in the system Fully combined with copper ions and amino residues in gelatin;

[0036] The third step is to take out the artificial ligament, blot dry with filter paper...

Embodiment 2

[0042] Present embodiment relates to a kind of preparation method of HAp blending silver and copper antibacterial agent composite coating, described method comprises the steps:

[0043] The first step is the pretreatment of the artificial ligament. The surface of the artificial ligament is ultrasonically cleaned for 30 minutes, rubbed repeatedly with steel grit with a surface roughness of 50um for 5 times, rinsed with distilled water for 3 times, and dried in vacuum;

[0044] In the second step, using water as solvent, 5 ml of 15 mmol / L CaCO 3 , AgNO 3 and CuSO 4 and 5 ml of 25 mg / L porcine gelatin solution, adjust the pH value to 7, and stir for 5 minutes at 25°C, then soak the artificial ligament in this mixture, and stir for 45 minutes to make the free Ca and Ag in the system Fully combined with copper ions and amino residues in gelatin;

[0045] The third step is to take out the artificial ligament, blot it dry with filter paper, and put in 10 ml of 50 mmol / L freshly prep...

Embodiment 3

[0048] Present embodiment relates to a kind of preparation method of HAp blending silver and copper antibacterial agent composite coating, described method comprises the steps:

[0049] The first step is the pretreatment of the artificial ligament. The surface of the artificial ligament is ultrasonically cleaned for 30 minutes, rubbed repeatedly with steel grit with a surface roughness of 25-50um for 10 times, rinsed with distilled water for 3 times, and dried in vacuum;

[0050] In the second step, using water as solvent, 5 ml of 15 mmol / L CaCO 3 , AgNO 3 Mix with copper source (copper nitrate: copper sulfate = 2:1 mixture) and 5 ml of 25 mg / L rabbit source gelatin solution, adjust the pH value to 8, stir at 25 ° C for 5 minutes, and then soak the artificial ligament in this mix In the solution, stir and react for 15 minutes, so that the free Ca and Ag and copper ions in the system can fully combine with the amino residues in the gelatin;

[0051] The third step is to take ...

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Abstract

The invention provides a preparation method of a HAp blended silver and copper antibacterial composite coating. The method comprises the following steps: first, conducting ultrasonic cleaning treatment on the artificial ligament surface, conducting friction by using the steel grit, cleaning by distilled water, and conducting vacuum drying; second, mixing gelatin and a calcium source solution, adding silver and copper sources to form a mixed solution, regulating the pH value, stirring, soaking artificial ligament in the mixed solution, and stirring; and third, remove the taking out the artificial ligament, drying with filter paper, dipping in a Na2HPO4 solution, stirring, standing, drying with filter paper, and repeating cycles of mineralization. The invention uses a biomimetic mineralization method to form the HAp blended silver and copper antibacterial agent composite coating with uniform mineralized structure and stable performance on the artificial ligament surface by using gelatin as the mineralization template. The coating modifies the artificial ligament and further realizes surface modification on artificial ligament, so that the artificial ligament has antibacterial and anti-inflammatory properties to reduce postoperative synovitis and complications such as infection of cruciate ligament reconstruction of knee joint.

Description

technical field [0001] The invention relates to a preparation method of artificial ligament, in particular to a preparation method of HAp mixed with silver and copper antibacterial agent composite coating. Background technique [0002] Polyethylene terephthalate (PET) artificial ligament is the graft choice for the reconstruction of knee cruciate ligament injury. A number of clinical studies have proved that its short-term curative effect and safety after operation are relatively satisfactory. Capacitive problems, synovitis, infection and other complications will occur; and the inflammatory products in the synovial fluid of the joint will destroy the structure of the joint and affect the healing of the tendon and bone. These become one of the important factors leading to the failure of knee cruciate ligament reconstruction surgery. Therefore, it is particularly important to improve the biocompatibility of PET materials, increase their antibacterial and anti-inflammatory pro...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/54
Inventor 陈世益陈俊张鹏蒋佳吴子英陈天午万方
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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