Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide

A bioactive, dopamine technology, applied in medical science, metal material coating process, prosthesis, etc., to achieve the effect of simple operation and growth promotion

Inactive Publication Date: 2014-11-12
TIANJIN UNIV
View PDF6 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, domestic research on graphene oxide has just started, mainly focusing on the functionaliz

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method step of the present invention design is as follows:

[0025] 1. Polish the pure titanium sheet with water sandpaper so that the surface roughness Ra is not greater than 1 μm, and then use acetone and deionized water to clean it ultrasonically. Nitric acid (HNO 3 ) Soak the sample for 10min-20min to remove surface oxides. After washing with water, immerse the sample in 40-80°C, 5-10mol / L sodium hydroxide (NaOH) solution for 30min-45min. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry at room temperature. Acid-base treated pure titanium samples were obtained.

[0026] 2. Prepare 2.0-3.0g / L dopamine-trishydroxymethylaminomethane (DA-Tris) solution.

[0027] 3. Immerse the treated pure titanium sample in the dopamine solution first, and let it stand at room temperature for 12h-24h to prepare the titanium / dopamine sample. After taking it out, wash it with deionized water, immerse it in 2.0-3.0g / L ...

Embodiment 1

[0030] 1) Polish the pure titanium sample with water sandpaper so that the surface roughness Ra is not greater than 1 μm, and then use acetone and deionized water to ultrasonically clean it. Nitric acid (HNO 3 ) (volume fraction 20%) soak the sample for 10 minutes to remove surface oxides. After washing with water, immerse the sample in a 40°C, 5mol / L sodium hydroxide (NaOH) solution for 45 minutes. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry it at room temperature. Acid-base treated pure titanium samples were obtained.

[0031] 2) Preparation of 2.0 g / L dopamine-tris(DA-Tris) solution: first prepare a 10 mmol / L tris (Tris) buffer solution with pH=8.5. Take 1.21g tris powder and dissolve it in 800ml deionized water, adjust the pH of the solution to 8.5 with 1mol / L hydrochloric acid (HCl), then pour the solution into a 1000ml volumetric flask for constant volume. Then, take an appropriate amount of dopamine hydrochlorid...

Embodiment 2

[0038] 1) The pure titanium sample was polished smooth with 600, 1000, 2000, and 2500 mesh water sandpaper, and then ultrasonically cleaned with acetone and deionized water. Nitric acid (HNO 3 ) (volume fraction 20%) soak the sample for 15 minutes to remove surface oxides. After washing with water, immerse the sample in a 60°C, 7mol / L sodium hydroxide (NaOH) solution for 40 minutes. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry it at room temperature. Acid-base treated pure titanium samples were obtained.

[0039] 2) Preparation of 2.5 g / L dopamine-tris-tris solution (DA-Tris): first prepare a tris buffer solution with pH=8.5. Dissolve 1.21g of Tris powder in 800ml of deionized water, adjust the pH of the solution to 8.5 with 1mol / L hydrochloric acid (HCl), and then pour the solution into a 1000ml volumetric flask for constant volume. Then, take an appropriate amount of dopamine hydrochloride to prepare a 2.0 g / L solutio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a method for improving biological activity of a pure titanium surface by using dopamine to be bonded with graphene oxide. The method comprises the following steps: successively carrying out ultrasonic cleaning on a pure titanium sheet of which the surface roughness Ra is not greater than 1micron by adopting acetone and deionized water; carrying out acid treatment by using a nitric acid, cleaning the pure titanium sheet by the deionized water, and then carrying out alkali treatment on a sample by using sodium hydroxide at 40-80 DEG C; preparing a dopamine-trihydroxymethyl aminomethane solution of which the pH is 8.5; soaking the processed pure titanium sample into the prepared dopamine solution, and standing the sample at room temperature for 12-24 hours; taking out the sample, cleaning the sample by using the deionized water, and drying the sample at room temperature, so as to prepare a titanium/dopamine sample; soaking the titanium/dopamine sample into a graphene oxide water solution and standing the sample at room temperature for 12-24 hours; and cleaning the sample by using the deionized water after taking out the sample, drying the sample at room temperature, so as to prepare a titanium/dopamine/graphene oxide sample. The method is simple to operate, green and pollution-free, mass production can be achieved, and a channel is expanded for surface modification of the titanium material.

Description

technical field [0001] The invention relates to a method for preparing a graphene oxide layer on the surface of pure titanium, in particular to a method for improving the biological activity of the surface of pure titanium by using dopamine to connect graphene oxide. Background technique [0002] Titanium and its alloys have been widely used in the field of biomaterials due to their low density and similar elastic modulus to bone. [1] (See: Liang Fanghui et al. Using pre-calcification treatment to improve the surface biological activity of alkaline heat-treated porous titanium [J]. Rare Metal Materials and Engineering, 2004, 33(10): 1359-1364), becoming a good choice for implant materials. However, titanium and its alloys are biologically inert materials, and after being implanted in the human body, they are mostly physically bonded to the bone [2] (See: Wang Xiaohong et al. Effect of TiO2 nanotube crystal form on titanium bioactivity [J]. Functional Materials, 2013, 9(44):...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C23C22/64C23C22/82A61L27/42A61L27/54
Inventor 高颖锟李朝阳朱胜利梁砚琴崔振铎杨贤金
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap