Composite local anesthetic and preparation method of composite local anesthetic injection

An injection and anesthesia technology, applied in the field of medicine, can solve the problems of delaying the best time for surgical treatment, and achieve the effects of long action time, good analgesic effect, and small toxic and side effects

Inactive Publication Date: 2014-11-19
广东埃纳生医疗投资发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In clinical application, the two will be used together according to the needs to achieve the purpose of quick onset, long duration of action and low side effects. However, som

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A compound local anesthetic injection, comprising:

[0046] Ropivacaine Mesylate 30g

[0047] Lidocaine Mesylate 65g

[0048] Sodium chloride 65g

[0049] Add water for injection to 10000ml.

[0050] A method for preparing the above-mentioned anesthetic injection:

[0051] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;

[0052] 2) Coarse filtration with activated carbon plate and frame filter;

[0053] 3) Adjust the pH to 5.0 with 0.1mol / L hydrochloric acid / sodium hydroxide;

[0054] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;

[0055] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;

[0056] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.

[0057] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness level of B, and steps (4)-(6) ar...

Embodiment 2

[0059] A compound local anesthetic injection, comprising:

[0060] Ropivacaine Hydrochloride 40g

[0061] Lidocaine Hydrochloride 45g

[0062] Sodium chloride 62g

[0063] Add water for injection to 10000ml.

[0064] A method for preparing the above-mentioned anesthetic injection:

[0065] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;

[0066] 2) Coarse filtration with activated carbon plate and frame filter;

[0067] 3) Adjust the pH to 5.2 with 0.1mol / L hydrochloric acid / sodium hydroxide;

[0068] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;

[0069] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;

[0070] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.

[0071] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness level of...

Embodiment 3

[0073] A compound local anesthetic injection comprising:

[0074] Ropivacaine Hydrochloride 30g

[0075] Lidocaine Hydrochloride 45g

[0076] Sodium chloride 62g

[0077] Add water for injection to 10000ml.

[0078] A method for preparing the above-mentioned anesthetic injection,

[0079] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;

[0080] 2) Coarse filtration with activated carbon plate and frame filter;

[0081] 3) Adjust the pH to 4.8 with 0.1mol / L hydrochloric acid / sodium hydroxide;

[0082] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;

[0083] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;

[0084] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.

[0085] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness l...

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PUM

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Abstract

The invention provides a composite local anesthetic which comprises lidocaine and ropivacaine, wherein the molar concentration ratio of lidocaine to ropivacaine is (1:1) to (1:3). The composite local anesthetic is clinically suitable for various local anesthesia and nerve blocking anesthesia. The invention further provides a preparation method of a composite local anesthetic injection. The composite local anesthetic has the advantages of stable component, convenience in use, quick action, long action time, good postoperative analgesia effect and small toxic and side effects.

Description

[0001] technical field [0002] The invention belongs to the field of medicine, and in particular relates to a preparation method of a compound local anesthetic and an injection thereof. Background technique [0003] Lidocaine is a medium-acting amide local anesthetic with fast onset and low cardiotoxicity. After injection, the drug distributes quickly and widely in tissues, and can penetrate the blood-brain barrier and placenta. It has high anesthesia intensity and strong diffusion power. , It takes about 2 hours for the drug to be eliminated from the local area, and it is a kind of universal local anesthetic. [0004] Ropivacaine is a new type of long-acting amide local anesthetic. Its action lasts for a long time, and it has anesthesia and analgesic effects. It produces sensory-motor nerve separation at low concentrations. It is used for spinal anesthesia and pain relief. The treatment is safe and effective, but compared with lidocaine, it is relatively more toxic to th...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/445A61P23/02A61K31/167
Inventor 陈宁陈顺俊索琨
Owner 广东埃纳生医疗投资发展有限公司
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