Composite local anesthetic and preparation method of composite local anesthetic injection
An injection and anesthesia technology, applied in the field of medicine, can solve the problems of delaying the best time for surgical treatment, and achieve the effects of long action time, good analgesic effect, and small toxic and side effects
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Embodiment 1
[0045] A compound local anesthetic injection, comprising:
[0046] Ropivacaine Mesylate 30g
[0049] Add water for injection to 10000ml.
[0050] A method for preparing the above-mentioned anesthetic injection:
[0051] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;
[0052] 2) Coarse filtration with activated carbon plate and frame filter;
[0053] 3) Adjust the pH to 5.0 with 0.1mol / L hydrochloric acid / sodium hydroxide;
[0054] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;
[0055] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;
[0056] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.
[0057] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness level of B, and steps (4)-(6) ar...
Embodiment 2
[0059] A compound local anesthetic injection, comprising:
[0060] Ropivacaine Hydrochloride 40g
[0061] Lidocaine Hydrochloride 45g
[0063] Add water for injection to 10000ml.
[0064] A method for preparing the above-mentioned anesthetic injection:
[0065] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;
[0066] 2) Coarse filtration with activated carbon plate and frame filter;
[0067] 3) Adjust the pH to 5.2 with 0.1mol / L hydrochloric acid / sodium hydroxide;
[0068] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;
[0069] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;
[0070] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.
[0071] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness level of...
Embodiment 3
[0073] A compound local anesthetic injection comprising:
[0074] Ropivacaine Hydrochloride 30g
[0075] Lidocaine Hydrochloride 45g
[0076] Sodium chloride 62g
[0077] Add water for injection to 10000ml.
[0078] A method for preparing the above-mentioned anesthetic injection,
[0079] 1) According to the prescription, dissolve ropivacaine, lidocaine and sodium chloride in 2000ml of water for injection;
[0080] 2) Coarse filtration with activated carbon plate and frame filter;
[0081] 3) Adjust the pH to 4.8 with 0.1mol / L hydrochloric acid / sodium hydroxide;
[0082] 4) Then filter through 0.45μm and 0.22μm filter membranes in turn;
[0083] 5) Sampling and detection of PH, foreign matter, suspended matter and drug content of intermediate products;
[0084] 6) After adding water for injection to 10000ml, aseptically fill it into a sterile ampoule.
[0085] The above steps (1)-(3) are all carried out in a GMP workshop with a cleanliness l...
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