Application of zedoary turmeric oil in preparation of psoriasis treatment medicines

A technology of psoriasis and zedoary oil, applied in the field of zedoary oil, can solve the problems affecting the quality of life of patients, toxic and side effects, and unsightly appearance of skin lesions, and achieve great clinical application value and no toxic and side effects

Inactive Publication Date: 2014-12-03
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different from other diseases, although about 80% of patients only have itching symptoms, psoriasis patients feel severe psychological pressure, low self-esteem, loss, and even suicidal tendencies due to the unsightly appearance of skin lesions, which greatly affects the patient quality of life
Modern medicine believes that the cause of this disease lies in the dysfunction of the immune system, and its treatment generally uses (oral or external) immunosuppressants, as well as corticosteroids or coal tar and other drugs that can improve the symptoms of skin lesions, such as anthralin, calcipotriol, Tazarotene, subcutaneous injection of corticosteroids or oral administration of Diyin tablets, retinoids, antineoplastic drugs and other methods, although short-term relief of symptoms is acceptable, but long-term application has serious side effects, and clinical efficacy is still lacking , Therapeutic drugs with few side effects

Method used

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  • Application of zedoary turmeric oil in preparation of psoriasis treatment medicines
  • Application of zedoary turmeric oil in preparation of psoriasis treatment medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] method of extraction:

[0013] Grind Zedoary and pass through a 20-mesh sieve, put it in an extraction kettle, add 10% ethanol as an entrainer, and extract continuously for 1.2 hours under the conditions of extraction pressure 24MPa and extraction temperature 50°C, and separate brown-yellow from the separation kettle. product.

Embodiment 2

[0015] Effect of zedoary oil on propranolol-induced psoriasis model:

[0016] 38 healthy adult albino guinea pigs, 4-5 weeks old, initial body weight 250-300g, male, numbered, weighed and recorded. According to the random number table method, 8 guinea pigs were taken as the blank control group, and the remaining 30 guinea pigs were used as the model group.

[0017] Apply 5% propranolol hydrochloride emulsion evenly to the skin of the back of the ears of guinea pigs with a cotton swab, apply the cream matrix externally according to the above method to build a model, and apply the blank matrix to the blank control group. The dosage for all animals is 0.2ml / ear each time, Evenly, make a thin layer on the back of the ears, 3 times a day, with an interval of 3 hours between each time. Observe the body weight change and state of the guinea pigs every day. After one week of modeling, it was observed that the guinea pigs basically appeared red, swollen or even skin lesions, and the ...

Embodiment 3

[0033] powder:

[0034] Curcuma Oil 5g

[0035] Cyclodextrin 50g

[0036] Lactose 150g

[0037] Tween-80 15g

[0038] Preparation:

[0039] Mix zedoary oil with other combinations and freeze-dry to get powder

[0040] Nanoemulsion:

[0041] Curcuma Oil 10g

[0042] Lecithin 5g

[0043] Pluronic 10g

[0044] Tween-80 2g

[0045] Glycerin 25g

[0046] Preparation:

[0047] Weigh the prescribed amount of glycerin and Tween-80, stir and disperse in appropriate amount of distilled water. Another appropriate amount of lecithin and Pluronic F-68 was added to the aqueous phase solution under stirring. After the lecithin and Planckney F-68 were completely dispersed, the zedoary oil was added dropwise to the water phase while magnetically stirring. Ultrasound for 6 minutes, that is, zedoary oil colostrum. Add distilled water to the colostrum to a certain amount under stirring, and then sonicate for 6min. The colloidal dispersion system was circulated three times at 130MPa...

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Abstract

The invention discloses an application of zedoary turmeric oil in the preparation of psoriasis treatment medicines. Animal tests prove that the zedoary turmeric oil has a substantial curative effect on psoriasis, and can be used for preparing the psoriasis treatment medicines. The zedoary turmeric oil has no toxic side effects, has no obvious untoward effects even after long term administration, and has great clinic application values.

Description

technical field [0001] The invention relates to a new application of zedoary oil. Background technique [0002] Psoriasis, commonly known as psoriasis, is a common chronic, relapsing, and immune-related disease. The clinical manifestations are based on infiltrating erythema, covered with multiple layers of silvery white phosphorous scales. Different from other diseases, although about 80% of patients only have itching symptoms, psoriasis patients feel severe psychological pressure, low self-esteem, loss, and even suicidal tendencies due to the unsightly appearance of skin lesions, which greatly affects the patient's quality of life. Modern medicine believes that the cause of this disease lies in the dysfunction of the immune system, and its treatment generally uses (oral or external) immunosuppressants, as well as corticosteroids or coal tar and other drugs that can improve the symptoms of skin lesions, such as anthralin, calcipotriol, Tazarotene, subcutaneous injection o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P17/06
Inventor 卢传坚赵瑞芝余靖宏肖志偲韩凌冯丽敏陈振兴
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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