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A kind of medical polyurethane pancreatic-intestinal stapler material and preparation method thereof

A technology of pancreaticojejunostomy and polyurethane, which is applied in the field of cast polyurethane polymer materials and its preparation, can solve the problems of poor anastomosis and growth of pancreas and intestines, achieve the effects of improving the surface and physical and chemical properties, improving mechanical properties, and simple operation

Inactive Publication Date: 2016-03-23
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the objectives of the present invention is to provide a polyurethane polymer elastomer material with high elasticity and tear resistance in order to overcome the medical problem that patients with pancreatic cancer need to join the pancreas and intestines and the pancreas and intestines are not easy to anastomose.

Method used

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  • A kind of medical polyurethane pancreatic-intestinal stapler material and preparation method thereof
  • A kind of medical polyurethane pancreatic-intestinal stapler material and preparation method thereof
  • A kind of medical polyurethane pancreatic-intestinal stapler material and preparation method thereof

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preparation example Construction

[0045] The preparation method of casting type polyurethane macromolecular material of the present invention comprises the following steps:

[0046] 1) Dehydration of polymer polyol: put polymer polyol in a reactor, dehydrate at 100-130°C, vacuum degree 0.09-0.10MPa for 2-3h, take it out, and cool to 50-60°C;

[0047] 2) Preparation of prepolymer or semi-prepolymer: according to the ratio of R value 2-5 and polyisocyanate and polymer polyol functionality of 2:1 or 1:1, the mass fraction after dehydration in step 1) is Add 18.5%-35.5% melted polyisocyanate to 57%-74% polymer polyol, and react for 2.5-3.5 hours according to step 1) under vacuum conditions at 80-90°C to obtain prepolymer or semi-prepolymer Polymer, sealed and stored at room temperature, ready for use;

[0048]3) Add additives: add 0.1%-1% antibacterial agent and 0.1%-0.5% defoamer to the prepolymer or semi-prepolymer at a temperature of 50-60°C in step 2);

[0049] 4) Chain extension of the prepolymer: melt the ...

Embodiment 1

[0055] According to the R value of 2-5 and the ratio of polyisocyanate and polymer polyol functionality of 1:1, the polyether polyol polytetrahydrofuran diol with a mass fraction of 60.9% was tested at 100°C under a vacuum pressure of 0.09MPa Dehydrate for 2.5 hours, take it out, and cool to 60°C; then add 35.5% MDI, and react at 85°C for 3 hours under a vacuum of 0.09MPa to obtain a semi-prepolymer with a temperature of 85°C, which is sealed and stored at room temperature; take 0.1 % of dimethylpolysiloxane and 0.1% of titanium dioxide nano-silver antibacterial agent are added to the semi-prepolymer at a temperature of 50°C, and 3% MOCA is melted at 80°C and quickly added to the semi-prepolymer at a temperature of 50°C At the same time, add 0.4% reinforcing agent gas-phase white carbon black, stir and react for 25 minutes, inject it into the mold; vacuum dry, 100 ° C for 0.5 h of vulcanization; then heat up to 120 ° C, vacuum dry, and secondary vulcanization for 10 h, that is,...

Embodiment 2

[0057] According to the R value of 2-5 and the ratio of polyisocyanate to polymer polyol functionality of 1:1, take a mass fraction of 57% polymer polyol polypropylene glycol, and dehydrate it at 120 ° C for 2 hours under a vacuum pressure of 0.10 MPa. Take it out, cool it to 50°C; then add 35.5% MDI, and react at 80°C for 3.5 hours under a vacuum of 0.10MPa to obtain a semi-prepolymer with a temperature of 80°C, which is sealed and stored at room temperature; take 0.5% dimethylformamide Base polysiloxane and 1% β-1,4-polyglucosamine were added to the semi-prepolymer at a temperature of 50°C, and 5% ethylene glycol was melted at 80°C and quickly added to the semi-prepolymer at a temperature of 50°C. At the same time, add 1% reinforcing agent gas phase white carbon black to the prepolymer, stir and react for 35 minutes, then pour into the mold; vacuum dry, 105 ° C for 1.0 h of vulcanization; then heat up to 110 ° C, vacuum dry, and secondary vulcanization for 12 h , That is, ca...

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Abstract

The invention discloses a medical polyurethane pancreaticojejunostomy device material and a preparation method thereof. The material comprises a prepolymer or a semi-prepolymer prepared by polymerization reaction of polyisocyanate and polymer polyol, a chain extender, a defoamer, an antibacterial agent and a reinforcing agent, wherein each component accounts for a certain mass fraction. The method comprises the following steps: (1) dehydration of polymer polyol; (2) preparation of the prepolymer or the semi-prepolymer; (3) addition of auxiliaries; (4) chain extension of the prepolymer; (5) first vulcanization; (6) second vulcanization for obtaining a casting type polyurethane elastomer material. The invention further discloses a medical anastomat prepared by utilizing the casting type polyurethane elastomer material, the anastomat is in the shape of a circular ring, and four titanium screws are uniformly distributed on the outer peripheral wall of the circular ring. The casting type polyurethane elastomer material is an elastomer material with high ductility and high tear strength, has no physiological toxicity, has high softness, high ductility, excellent medium resistance and the like, and can be widely applied to the field of medicine.

Description

technical field [0001] The invention relates to a medical polyurethane pancreatic-intestinal stapler material in the medical field, in particular to a castable polyurethane polymer material with better elasticity and better tear resistance and a preparation method thereof. Background technique [0002] Polyurethane is a polymer synthetic material with properties between rubber and plastic. It is characterized by a wide range of hardness adjustment. It has both the elasticity of rubber and the hardness of plastic, and has good resilience. Casting polyurethane elastomer is a prepolymer obtained by reacting polyol polymer and polyisocyanate, and then reacts with a chain extender to cure at high temperature. [0003] A temperature-resistant polyurethane elastomer disclosed in Chinese patent 97101134.6, the material composition is (equivalent ratio) isocyanate: dehydrated diol: compound containing isocyanurate ring and active hydrogen according to 1:0.8:0.1~1:0.1: Add the propor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16
Inventor 李颖
Owner XIAN UNIV OF SCI & TECH
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