Biodegradable material and method for producing biodegradable material

A biodegradable, compound technology, used in tissue regeneration, bandages, surgery, etc., can solve problems such as polymer particle deformation, and achieve the effects of improved flexibility, improved shear strength, and improved shape recovery rate

Inactive Publication Date: 2016-04-20
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0029] However, improved techniques such as blending of various polymers (Patent Document 7) and use of chemically crosslinked polymer particles (Patent Document 8) and surface coating of polymer particles (Patent Document 9) are not available. In other words, improvements have been confirmed in terms of controlling the flexibility of polymer particles and improving catheter penetrability, but sufficient improvement has not been confirmed for the problem that polymer particles deform and do not return to their original shape. In order to obtain a suitable The embolization effect of blood vessels etc. needs further improvement

Method used

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  • Biodegradable material and method for producing biodegradable material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0217] 10.0 g of 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) and 22.0 g of lactide (PURASORBL; manufactured by PURAC BIOMATERIALS) of hydroxycarboxylic acid a2 were taken into a tomato type bottle. These were melt-mixed at 120° C. under an argon atmosphere, and 0.94 mL of tin (II) octoate toluene solution was added as a catalyst (tin (II) octoate (manufactured by Sigma-Aldrich Co.,) was dissolved in toluene (Wako Pure Chemical Industries, Ltd. Co., Ltd., adjusted to a concentration of 0.16 g / mL), and a copolymerization reaction was performed under normal pressure for 20 hours to obtain an unpurified multi-component compound A1.

[0218] The obtained unrefined multi-component compound A1 was added dropwise to 100 mL of diethyl ether, and after the precipitate and liquid components separated from diethyl ether were collected, they were further washed with 50 mL of diethyl ether for 3 times to obtain the refined multi-component comp...

Embodiment 2）

[0227] Respectively change the consumption of solution 1 to 0.570mL, change the consumption of solution 2 to 0.430mL, change the consumption of DMAP solution to 0.022mL, change the consumption of EDC to 0.038mL, except that, carry out the same as Example 1 Operation, thereby obtaining biodegradable membrane 2 and acetonitrile-containing membrane 2.

[0228] These biodegradable film 2 and acetonitrile-containing film 2 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0229] As shown in Table 1, the biodegradable film 2 has a large compressive load and a high recovery rate. In addition, the complex elastic modulus of the acetonitrile-containing membrane 2 is large, and the gelation time is also fast.

Embodiment 3）

[0231] Change the consumption of solution 1 to 0.399mL, change the consumption of solution 2 to 0.601mL, change the consumption of DMAP solution to 0.030mL, and change the consumption of EDC to 0.053mL, except that, carry out the same as Example 1 Operation, thereby obtaining biodegradable membrane 3 and acetonitrile-containing membrane 3.

[0232] These biodegradable films 3 and acetonitrile-containing films 3 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0233] As shown in Table 1, the biodegradable film 3 has a large compressive load and a high recovery rate. In addition, the complex elastic modulus of the acetonitrile-containing membrane 3 is large, and the gelation time is also fast.

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Abstract

An object of the present invention is to provide a biodegradable material with improved shape recovery rate after material deformation and improved flexibility. The present invention provides a biodegradable material in which a polyvalent compound A having a functional group X such as three or more hydroxyl groups and a polyvalent compound B having a functional group Y such as three or more carboxyl groups are chemically cross-linked through a condensation reaction between the functional group X and the functional group Y. When the number of functional groups X not condensed with functional group Y is denoted as x, the number of functional groups Y not condensed with functional group X is denoted as y, the number of chemical crosslinks is denoted as z, and the number of polyvalent compounds A is When the weight average molecular weight is written as MA and the weight average molecular weight of the polyvalent compound B is written as MB, when MA≥MB, the value of (y+z) / (x+z) is 1.2 to 4.0, and when MA<MB, the The value of (x+z) / (y+z) is 1.2 to 4.0.

Description

technical field [0001] The present invention relates to a biodegradable material and a method for producing the biodegradable material. Background technique [0002] Poly(lactic acid / glycolic acid) copolymers are used as polymer particles for embolization of blood vessels in order to stop bleeding during incision of the affected part, block the nutrient supply to the tumor, maintain the concentration of anticancer agents in the tumor, etc. (Patent Document 1); block copolymers of polyethylene glycol and polylactic acid (Patent Documents 2 to 5); or multi-block copolymers obtained by copolymerizing lactic acid, polyethylene glycol, and polycarboxylic acids (Patent Document 6 ). [0003] Such polymer particles for embolization of blood vessels etc. use spherical particles in order to embolize blood vessels etc. without gaps, but since they are delivered to target sites such as blood vessels through microcatheters with small diameters, there are the following problems : Block...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/06A61L31/00A61L15/64A61L17/00C08L101/16
CPCA61L15/64C08L101/16A61L31/148A61L24/0042C08G63/08C08G63/668C08L67/02A61L2430/36C08L67/025C08L67/04A61L15/26A61L24/046
Inventor 藤田雅规中西惠棚桥一裕
Owner TORAY IND INC
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