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Traditional Chinese medicine preparation with hypoglycemic effect

A traditional Chinese medicine preparation and blood sugar-lowering technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc. It can solve the problems that the blood-sugar-lowering effect has not been published, has not been reported, and has not been studied much.

Inactive Publication Date: 2014-12-10
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are not many studies on the leaves of Orchid chinensis using contemporary Chinese medicine chemical technology and modern pharmacological technology. The understanding of the chemical components of Orchid chinensis leaves is limited to major components. Some literature points out that it contains sugars, polysaccharides, flavonoids, proteins , lactones and other components; for the pharmacological action and clinical application of Orchid chinensis leaves, there are literatures pointing out that it has anti-cancer, anti-oxidation, antibacterial and other effects, and the research on the pharmacological action of hypoglycemia has not been reported yet; patent documents mostly involve cultivation Technology, food processing, etc., there are few patents related to drug development and pharmacological effects, and patents related to hypoglycemic effects have not yet been published

Method used

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  • Traditional Chinese medicine preparation with hypoglycemic effect
  • Traditional Chinese medicine preparation with hypoglycemic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Fresh leaves of Orchid chinensis, chopped with random knives, boiled and extracted 2 times with 10 times the amount of pH 11 alkaline water (adjusted with sodium hydroxide), 2 hours for the first time, 1 hour for the second time, while hot Filter the extracts, merge, adjust to pH 1 with hydrochloric acid while hot, cool while standing, filter after 36 hours, the AB-8 macroporous resin column on the filtrate, flow rate 1BV / h (per hour flows through equivalent to a resin Fluidized bed volume, the same below), after flavonoid adsorption is saturated, the column is washed with water, followed by elution with 65% ethanol aqueous solution, and the D 301 Macroporous resin column, flow rate 1BV / h, collect effluent, recover solvent to dilute paste. After the thin paste is dried, the content of flavonoids in the dry paste is 74.6%.

Embodiment 2

[0015] Embodiment 2: the leaves of Orchid chinensis are dried in the sun, beaten into the coarsest powder, extracted twice at 85°C with 15 times the amount of pH 9 alkaline water (adjusted with lime water), each for 1.5 hours, and the extract is filtered while it is hot. Merge, adjust to pH 2 with sulfuric acid while hot, cool while standing, and filter after 24 hours, the AB-8 macroporous resin column on the filtrate, flow rate 1BV / h (flowing through is equivalent to a resin fluidized bed volume per hour, the lower Same), after flavonoid adsorption saturation, wash the column with water, then use 75% ethanol aqueous solution to elute, the alcohol eluent on D 301 Macroporous resin column, flow rate 1BV / h, collect the effluent, recover the solvent to form a thick paste, then dry it, and grind it into fine powder (60-80 mesh). Taking rutin as a control, the content of flavonoids in the fine powder is 68.2%.

[0016] Two, the following is the implementation example of preparing ...

Embodiment 3

[0017] Example 3: Calculated according to the yield of the effective parts, take a thin ointment equivalent to 1000g of the effective parts of the orchid leaf crude drug, with a volume of 184ml, add 1200g of white sugar, heat to dissolve, finally add water to 2000ml, filter, and take it orally Liquid, sub-packaged, each 10ml, each containing 5g of a leaf orchid leaf crude drug.

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Abstract

The invention relates to a traditional Chinese medicine preparation with a hypoglycemic effect and a production method thereof. The traditional Chinese medicine preparation is characterized by using leaves, commonly known as zongzi leaves and indocalamus leaves, of a liliaceous plant Aspidistra Elatior Blume as raw materials, extracting flavonoid constituents from the leaves of Aspidistra Elatior Blume and adopting a conventional method for forming medicine preparations to prepare an oral medicine which can be medically and clinically used. Pharmacological experiment results show that the traditional Chinese medicine preparation has the functions of inhibiting and reducing high blood sugar of experimental animals.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmaceutical engineering, and relates to a traditional Chinese medicine preparation with hypoglycemic effect, in particular, it is prepared by extracting flavonoids from the leaves of Aspidistra Elatior Blume (commonly known as Zongye and Ruoye) as raw materials. The finished traditional Chinese medicine preparation and its production method. Background technique [0002] Aspidistra elatior Blume is a perennial evergreen herbaceous plant with perennial roots. It is a plant of the Liliaceae family. Zongzi is made of rice dumplings, so it is commonly known as Zongye, also known as Ruoye. [0003] One-leaf orchid can be used as ornamental bonsai, but most of them are wild. They are widely grown in the south of the Yangtze River in my country. They are an important material for folks in the south of the Yangtze River to make zongzi, so they are commonly called zongye. It can also be use...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P3/06
Inventor 李学坚黄云胡文姬
Owner GUANGXI UNIV OF CHINESE MEDICINE
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