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Preparation for treating oral mucositis caused by paraquat

A technology for oral mucositis and preparations, which is applied in the field of preparations for the treatment of oral mucositis caused by bacterial quat, and can solve the problems of low effective rate and inapplicability to oral mucositis and the like

Inactive Publication Date: 2014-12-17
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of this method is: the total effective rate is low, probably maintained at about 60%
[0005] The application number is 200610012661.1, and the authorized announcement number is the Chinese patent document CN 101066298 B. The name is a kind of traditional Chinese medicine powder for the treatment of oral mucositis. For common small ulcers with a diameter of 1-3 mm, not suitable for oral mucositis caused by paraquat

Method used

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Examples

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Embodiment Construction

[0012] The present invention can be explained in detail through the following examples, and the purpose of disclosing the present invention is to protect all technical improvements within the scope of the present invention.

[0013] Choose 1 part of 0.9% sodium chloride as 250ml, 1 part of 2% lidocaine as 0.16g, 1 part of dexamethasone as 0.005g, and 1 part of gentamicin as 0.08g. Take 0.9% sodium chloride, 2% lidocaine, dexamethasone, and Qingda, one portion each, mix and stir evenly to obtain oral mucositis preparation caused by diquat, and the patient gargles once every 2 hours during the day.

[0014] Clinical data From 2010 to 2013, 68 patients with paraquat were treated in our hospital, including 31 males and 37 females, aged 16-27 years. The time to see a doctor is 3-48 hours after oral or buccal. Among them, 7 cases had mild side effects such as vomiting and dizziness due to large oral doses. 26 patients who had not swallowed the drug were cured and discharged within...

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Abstract

A preparation for treating oral mucositis caused by paraquat. The preparation particularly includes following components: 250ml of a 0.9% sodium chloride solution, 0.16g of 2% lidocaine, 0.005g of dexamethasone and 0.08g of gentamicin. The preparation can reduce oral mucositis damage of a paraquat poisoning patient, can alleviating pain, can resist infection and can inhibit immunity. The preparation is used in a manner of mouth wash. A patient uses the preparation in the mouth-washing manner per 2 hours in daytime so that stimulation during local drug delivery is avoided and pain is alleviated. By means of frequent mouth washing, oral cavity can be moistened and large residue blocks and necrotic tissues can be removed. The preparation can reduce secretion and dental plaque, promotes a self-cleaning function of the oral cavity. A mouth washing liquid is low in cost and has an important clinical application value.

Description

technical field [0001] The invention belongs to the field of oral disease treatment, in particular to a preparation for treating oral mucositis caused by paraquat. Background technique [0002] Paraquat, also known as Paraquat, Gramoxone, chemical name is 1,1-dimethyl 4,4-bipyridine cationic salt, exists in cationic form, its poisoning and treatment mechanism is still in the exploration stage, it is a kind of toxic A strong organic heterocyclic contact herbicide for agricultural use, which has a strong toxic effect on humans and livestock. In recent years, with the wide application of paraquat, more and more patients are poisoned by paraquat. Most of them are poisoned by mistake or suicide. Paraquat is corrosive. After oral poisoning, patients’ mouth, tongue, throat, Both the esophagus and gastric mucosa can cause ulcers, bleeding, and pain, and a capsule is formed on the surface, which is very susceptible to infection. Patients with paraquat poisoning have a high mortalit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P39/02A61P1/02A61K31/573A61K31/167
Inventor 宋丽妞宋丽平马瑜瑾姜宏卫王朝娟
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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