Method for simultaneously extracting schisandra chinensis volatile oil and lignans

A technology for volatile oil and lignans of Schisandra chinensis is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., to achieve the effects of improving yield, high yield and strong selectivity

Inactive Publication Date: 2014-12-17
NANJING BIAOKE BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the literature, there is no report on the extraction of volatile oil and lignans from Schisandra chinensis by the combination of compound enzyme fermentation and ultrasonic-microwave-assisted extraction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Crush the fruit of Schisandra chinensis, pass through a 40-mesh sieve, add a compound enzyme (mixed enzyme with a weight ratio of 0.5:0.3:0.2 of cellulase, hemicellulase and protease) of raw material quality, mix well and spray distilled water to reach hand Just hold it into a ball, wrap it with a film and seal it, and ferment it at a temperature of 30°C for 10 days; add 7 times the n-hexane to the fermented raw material, put it in an ultrasonic-microwave extractor for extraction, control the ultrasonic wave at 500W, and the microwave power at 300W Continuously extract for 1.5h, filter, and concentrate the filtrate under reduced pressure at 50°C to obtain the volatile oil of Schisandra chinensis, with a yield of 15.4%; add 7 times of 70% ethanol solution to the filter residue obtained above, and place it in an ultrasonic-microwave extractor for extraction , controlled ultrasonic wave 500W, microwave power 600W continuous extraction for 3 hours, filtered; the filtrate was...

Embodiment 2

[0020] Crush the fruit of Schisandra chinensis, pass through a 40-mesh sieve, add a compound enzyme with 1.5% raw material mass (a mixed enzyme with a weight ratio of cellulase, hemicellulase and protease of 0.5:0.3:0.2), mix well and spray distilled water to achieve hand Just hold it into a ball, wrap it with a film and seal it, and ferment it at a temperature of 40°C for 8 days; add 6 times the n-hexane to the fermented raw material, put it in an ultrasonic-microwave extractor for extraction, control the ultrasonic wave at 500W, and the microwave power at 350W Extract continuously for 1 hour, filter, and concentrate the filtrate under reduced pressure at 40°C to obtain the volatile oil of Schisandra chinensis, with a yield of 16.8%; add 6 times the 75% ethanol solution to the filter residue obtained above, and place it in an ultrasonic-microwave extractor for extraction. Controlled ultrasonic wave 500W, microwave power 500W continuous extraction for 2.5h, filtered; the filtra...

Embodiment 3

[0022] Crush the fruit of Schisandra chinensis, pass through a 40-mesh sieve, add 2% compound enzyme (mixed enzyme of cellulase, hemicellulase and protease by weight ratio of 0.5:0.3:0.2) of raw material, mix evenly and spray distilled water to reach hand Just hold it into a ball, wrap it with a film and seal it, and ferment it at a temperature of 45°C for 5 days; add 5 times the n-hexane to the fermented raw material, put it in an ultrasonic-microwave extractor for extraction, control the ultrasonic wave at 500W, and the microwave power at 400W Extract continuously for 0.5h, filter, and concentrate the filtrate under reduced pressure at 30°C to obtain the volatile oil of Schisandra chinensis, with a yield of 15.1%; add 5 times the 80% ethanol solution to the obtained filter residue, and place it in an ultrasonic-microwave extractor Carry out extraction, control ultrasonic wave 500W, microwave power 400W continuous extraction 2h, filter; The filtrate is extracted with ether, de...

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Abstract

The invention relates to a method for simultaneously extracting schisandra chinensis volatile oil and lignans. The method is characterized by comprising the following steps: grinding schisandra chinensis fruits, screening by a 40-mesh screen, and fermenting by complex enzyme; adding n-hexane which is 5-7 times that of the fermented raw material into the fermented raw material; extracting in an ultrasonic-microwave extractor, filtering, and concentrating the filtrate at 30-50 DEG C in reduced pressure to obtain the schisandra chinensis volatile oil; adding a 70-80% ethanol solution which is 5-7 times that of filter residues into the filter residues, extracting in the ultrasonic-microwave extractor, and filtering; and performing organic solvent extraction, reduced-pressure concentration, drying and other steps on the extract to obtain a schisandra chinensis lignans product. The method is easy to operate and remarkable in technical effect, and is capable of simultaneously extracting main effective components in the schisandra chinensis, and the comprehensive utilization value of the medicinal material can be remarkably increased.

Description

technical field [0001] The invention relates to a method for simultaneously extracting volatile oil and lignans from schisandra chinensis. Background technique [0002] Schisandra chinensis is the dry and mature fruit of Schisandra chinensis or Schisandra chinensis of Magnoliaceae. It is warm in nature and named after the fruit has five flavors of sweet, sour, pungent, bitter and salty. It is one of the commonly used traditional Chinese medicines for chronic cough, shortness of breath, nocturnal emission, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, thirsty wounds, shortness of breath and pulse deficiency, internal heat and thirst, palpitations and insomnia. The bioactive components of Schisandra chinensis are mainly volatile oil and lignans. Among them: volatile oil containing citral, α -Chamiene, β -Chamiene and chamiltaldehyde, etc., the content is about 1.6%; lignans contain schisandrin, schisandrin A, schisandrin B, schisandrin A, etc., the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57
Inventor 张金芳杨存
Owner NANJING BIAOKE BIO TECH
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