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Spinning enhanced parylene composite film and preparation method thereof

A parylene and composite film technology, applied in textiles and papermaking, medical science, non-woven fabrics, etc., can solve problems affecting device performance, biological tissue damage, shedding, etc., and achieve simple process and good mechanical stretching The effect of low performance and manufacturing cost

Active Publication Date: 2016-01-13
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that as the electrodes are reused or implanted into biological tissues for a long time, the pure parylene film as a covering and insulating material will gradually peel off from the substrate or even fall off, which will affect the performance of the device and may even affect the performance of the device. biological tissue damage

Method used

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  • Spinning enhanced parylene composite film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Such as figure 1 As shown, the present embodiment provides a method for preparing a spinning reinforced parylene composite film, including:

[0028] 1. Dissolve polylactic acid (PLA) in chloroform (chloroform), and fully dissolve the solute by heating and stirring to form a polylactic acid spinning solution;

[0029] 2. Deposit the polylactic acid spinning solution on the stainless steel sheet substrate by electrospinning to form a single spinning structure with a diameter of 10 to 100 nanometers;

[0030] 3. Chemical vapor deposition of a 1 micron ParyleneC film on a stainless steel sheet substrate covered with a spinning structure;

[0031] 4. The film deposited on the stainless steel sheet substrate is released from the substrate to form a polylactic acid spinning reinforced ParyleneC composite film. Compared with the pure parylene ParyleneC film, the bonding force of the prepared polylactic acid spinning enhanced paryleneC composite film on the stainless steel sub...

Embodiment 2

[0033] Such as figure 1 As shown, the present embodiment provides a method for preparing a spinning reinforced parylene composite film, including:

[0034] 1. Dissolve polycaprolactone (PCL) and titanium dioxide nanoparticles in a mixture of chloroform (chloroform) and dimethylformamide (DMF), and fully dissolve the solute by stirring to form polycaprolactone (PCL ) and titanium dioxide nanoparticles mixed spinning solution;

[0035] 2. Deposit the mixed spinning solution of polycaprolactone and titanium dioxide nanoparticles on the glass substrate by electrospinning to form a single spinning structure with a diameter of 400 to 600 nanometers;

[0036] 3. Chemical vapor deposition of a 5 micron ParyleneD film on a glass substrate covered with a spinning structure;

[0037] 4. Peeling and releasing the film deposited on the glass substrate from the substrate to form a ParyleneD composite film enhanced by spinning of polycaprolactone and titanium dioxide nanoparticles. Compared...

Embodiment 3

[0039] Such as figure 1 As shown, the present embodiment provides a method for preparing a spinning reinforced parylene composite film, including:

[0040] 1. Dissolve polylactic acid-glycolic acid (PLGA) and nerve growth factor (NGF) in a mixture of chloroform (chloroform) and dimethylformamide (DMF), and fully dissolve the solute by heating and stirring to form Polylactic-glycolic acid (PLGA) and nerve growth factor (NGF) mixed spinning solution;

[0041] 2. Deposit the mixed spinning solution of polylactic acid-glycolic acid (PLGA) and nerve growth factor (NGF) on the polystyrene substrate by electrospinning to form a single spinning structure with a diameter of 5 to 10 microns;

[0042] 3. Chemical vapor deposition of a 20-micron ParyleneN film on a polystyrene substrate covered with a spinning structure;

[0043] 4. The film deposited on the polystyrene substrate is released from the substrate to form a polylactic-glycolic acid (PLGA) and nerve growth factor (NGF) spinn...

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Abstract

The invention provides a spinning-enhanced parylene composite film and a preparation method thereof. The method comprises the following steps: firstly, dissolving a biocompatible material into an organic solvent to form a spinning solution; then forming a spinning structure on a substrate in an electrostatic spinning manner; finally depositing a parylene composite film on the substrate covered with the spinning structure; stripping and releasing the deposited thin film from the substrate, to form the spinning-enhanced composite thin film. The prepared parylene composite film has good metal substrate binding force, mechanical tensile property and thermological and ultraviolet stability; the functions and properties of the composite thin film can be regulated and controlled easily by changing varieties of materials and the preparation parameters; and the preparation method for preparing the spinning-enhanced parylene composite film is simple in the technological process, low in manufacturing cost and beneficial to massive repeated preparation.

Description

technical field [0001] The invention relates to a surface coating film in the technical field of biomedical engineering and a preparation method thereof, in particular to a spinning reinforced parylene composite film and a preparation method thereof. Background technique [0002] With the continuous development of micromachining technology, more and more implantable and interventional medical devices and medical electronic devices have been developed and widely used in clinical treatment, such as: vascular stents, minimally invasive medical guide wires and heart pacemaker. Such medical devices and electronic devices face the same problem in the process of directly contacting and functioning with human tissue through surgery, that is, the biocompatibility problem when directly interacting with tissue, that is, causing as little damage to biological tissue as possible. Rejection, reduce damage to biological tissue. In this way, film materials with good biocompatibility are r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06D04H1/728
Inventor 刘景全田鸿昌康晓洋何庆杨斌陈翔杨春生
Owner SHANGHAI JIAOTONG UNIV
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