A traditional Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin and its preparation method

A technology of chronic kidney disease and traditional Chinese medicine preparation, which is applied in the treatment of hematuria, proteinuria and abnormal renal function caused by chronic kidney disease with deficiency of both qi and yin, Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin and its preparation field , can solve the problems of not strengthening the spleen and kidney qi from the source to restore the subtle substances, proteinuria without targeted treatment, and the awareness rate is only 12.5%, and achieve the effect of adjusting viscera function, protecting kidney function, and improving resistance

Active Publication Date: 2016-01-13
湖北省中医院
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Problems solved by technology

In 2012, led by Professor Wang Haiyan from the Nephrology Department of Peking University First Hospital, the results of a cross-sectional study involving 13 provinces, municipalities, and autonomous regions across the country "China Chronic Kidney Disease Epidemiological Survey" showed that the prevalence of CKD among people over the age of 18 in my country The rate is 10.8%. Based on this estimate, the existing CKD patients in my country will reach 120 million, but the awareness rate is only 12.5%.
[0005] Chinese patent: The patent authorization announcement number is CN1057465C, and the invention patent on October 18, 2000 discloses a medicine for treating chronic kidney disease and a preparation method thereof, which consists of the following medicines in parts by weight: Radix Astragali 8-16 , Angelica 1‐9, Ginseng 4‐12, Rehmannia 8‐16, Atractylodes 4‐12, Poria 4‐12, Alisma 4‐12, Danpi 4‐12, Coptidis 4‐12, Cinnamon 4‐12, Fangji 4‐12, Ophiopogon japonicus 4‐12, Schisandra 4‐12, this formula has the functions of invigorating qi and nourishing yin, drying damp and clearing heat, mainly for chronic renal failure and chronic renal insufficiency caused by deficiency of both qi and yin and accumulation of damp heat. Treatment of proteinuria such as glomerulonephritis and nephrotic syndrome, but no clear curative effect on hematuria and abnormal renal function
This formula has the functions of nourishing the kidney and strengthening the spleen, nourishing blood and removing blood stasis, detoxification and reducing turbidity. It is mainly based on nourishing the kidney, strengthening the spleen and nourishing blood, and pays attention to removing stasis, detoxifying and reducing turbidity to promote the excretion of toxins in the body, but ignores dampness. Gujing, that is, the recovery of spleen and kidney qi and the solidification of fine substances are not enhanced from the source, and there is no targeted treatment for hematuria and proteinuria that often occur in patients with chronic kidney disease

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  • A traditional Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin and its preparation method
  • A traditional Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin and its preparation method

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preparation example Construction

[0025] A preparation method of a traditional Chinese medicine preparation for treating chronic kidney disease with Qi and Yin deficiency syndrome, the preparation method comprises the following steps in sequence:

[0026] Decoction: mix the raw materials according to the required ratio, add water and decoct 3 times to obtain a decoction, wherein the added weight of the water is 9-10 times the sum of the weight of each raw material;

[0027] Concentration under reduced pressure: firstly combine the decoctions and then filter, then take the filtrate to stand overnight and separate the supernatant, then concentrate the supernatant under reduced pressure to obtain a thick paste with a relative density of 1.2-1.3;

[0028] Granulation: First add dextrin to the thick paste and mix evenly, then dry under reduced pressure, pulverize, and pass through an 80-mesh sieve to obtain medicinal powder, and then sequentially granulate, dry, and granulate the medicinal powder to obtain a traditi...

Embodiment 1

[0036] A traditional Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin. The raw material composition and weight ratio of the traditional Chinese medicine preparation are: 10 rehmannia, 10 poria cocos, 10 yam, 8 cornus, 10 astragalus, 10 codonopsis, 10 coix seed, Corn Silk 10, Imperata 15, Madder 10, Thistle 10, Golden Cherry Seed 10, Gorgon 10;

[0037] When preparing, follow the steps below:

[0038] Decoction: Mix the raw materials according to the required ratio, add water and decoct 3 times to obtain a decoction, wherein the added weight of the water is 10 times the sum of the weight of each raw material, and the time for each decoction is 2 hours;

[0039] Concentration under reduced pressure: firstly combine the decoctions and filter them, then take the filtrate to stand overnight and separate the supernatant, then concentrate the supernatant under reduced pressure to obtain a thick paste with a relative density of 1.25, ...

Embodiment 2

[0042] Step is with embodiment 1, and difference is:

[0043] The raw material composition and weight ratio of the traditional Chinese medicine preparation are as follows: 12 shengdi, 12 poria cocos, 12 yam, 10 dogwood, 12 astragalus, 12 codonopsis, 12 coix seed, 12 corn silk, 18 imperata root, 12 madder, 12 small thistle , golden cherry seed 12, Gorgon fruit 12;

[0044] In the decocting step, the added weight of the water is 9 times of the sum of the weight of each raw material, and the decocting time is 1.5h each time;

[0045] In the granulation step, the temperature of the vacuum drying is 70°C and the pressure is 0.07Mpa.

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating qi-yin deficiency syndrome of a chronic kidney disease. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 8-12 parts of dried radix rehmanniae, 8-12 parts of poria cocos, 8-12 parts of Chinese yam, 6-10 parts of dogwood, 8-12 parts of astragalus membranaceus, 8-12 parts of codonopsis pilosula, 8-12 parts of semen coicis, 8-12 parts of corn stigma, 12-18 parts of lalang grass rhizome, 8-12 parts of madder, 8-12 parts of herba cepbalanoplosis segeti, 8-12 parts of fructus rosae laevigatae and 8-12 parts of semen euryales. The preparation method comprises the following steps: during preparation, firstly, decocting various raw materials for three times according to the required ratio; mixing decoctions of three times; filtering and concentrating into thick paste of which the relative density is 1.2-1.3; and adding auxiliary materials, pelletizing and drying to prepare the traditional Chinese medicine preparation. The traditional Chinese medicine preparation has the efficacies of tonifying the kidneys and spleen, securing essence and clearing dampness, and tonifying qi and nourishing yin, and has a significant curative effect on hematuresis, proteinuria and abnormal renal function caused by chronic kidney diseases when the kidney function is protected.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine preparation for treating chronic kidney disease with deficiency of both qi and yin and a preparation method thereof, and is particularly suitable for treating chronic kidney disease with deficiency of both qi and yin on the basis of protecting kidney function. Hematuria, proteinuria and abnormal renal function. Background technique [0002] In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines for the evaluation and management of chronic kidney disease (KDIGO) defined chronic kidney disease (CKD) as kidney damage or glomerular filtration rate in 2012. (GFR)<GFR<60ml / (min·1.73m 2 ) persists for more than 3 months. Clinically, it includes chronic glomerulonephritis, nephrotic syndrome, IgA nephropathy, chronic interstitial nephritis, various secondary kidney diseases, and chronic renal fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61P13/12
CPCA61K9/1652A61K36/076A61K36/28A61K36/344A61K36/40A61K36/481A61K36/62A61K36/738A61K36/74A61K36/804A61K36/8945A61K36/899A61K36/8994A61K2236/30A61K2236/331A61K2236/39A61K2300/00
Inventor 巴元明
Owner 湖北省中医院
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