Externally applied pharmaceutical preparation for treating skin superficial fungal infections
A topical drug, fungal infection technology, applied in antifungal agents, medical preparations containing active ingredients, skin diseases, etc., to achieve the effects of great clinical application value, saving treatment costs, and low recurrence rate
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Embodiment 1
[0019] The preparation of embodiment 1 external film preparation
[0020] (1) Weigh 10g of polyvinyl alcohol 05-88 and 4g of sodium carboxymethyl cellulose, respectively add 30 and 40ml of purified water to moisten, stir, soak for 36 hours to make it fully swell, and then heat in a water bath at 90°C until dissolved. Get polyvinyl alcohol 05-88 mucilage liquid and carboxymethyl cellulose sodium mucilage liquid respectively, and set aside.
[0021] (2) Weigh 0.5g of 2-hydroxy-3-carbonyl-23-norolean-1,4,12-triene-28-acid in a mortar, add 2g of azone, 2g of Tween-80 , 1g glycerin, and the polyvinyl alcohol 05-88 mucilage solution and sodium carboxymethylcellulose mucilage solution prepared in step (1), and grind them while adding until they are evenly ground. , to obtain the drug film slurry.
[0022] (3) Pour the drug film slurry on a sterile glass plate, spread it evenly, and dry it in an oven at 65°C. After the film is formed, remove the film and cut it into 6cm×8cm small p...
Embodiment 2
[0023] The preparation of embodiment 2 external film preparation
[0024] (1) Weigh 30g of polyvinyl alcohol 05-88 and 10g of sodium carboxymethyl cellulose, respectively add 100ml of purified water to moisten, stir, and soak for 48 hours to make them fully swell, and then heat in a water bath at 90°C until dissolved, respectively, to obtain Polyvinyl alcohol 05-88 mucilage and sodium carboxymethyl cellulose mucilage, for later use.
[0025] (2) Weigh 1g of 2-hydroxy-3-carbonyl-23-norolean-1,4,12-triene-28-acid in a mortar, add 5g of azone, 5g of Tween-80, 3g of glycerin, as well as the polyvinyl alcohol 05-88 mucilage prepared in step (1) and sodium carboxymethyl cellulose mucilage, grind them while adding until they are evenly ground, then place them in a water bath at 60°C for 30 minutes, remove the air bubbles, Get the medicine film slurry.
[0026] (3) Pour the drug film slurry on a sterile glass plate, spread it evenly, and dry it in an oven at 65°C. After the film i...
Embodiment 3
[0029] Example 3 Experimental Study on the Treatment of Drugs to Trichophyton mentagrophytes Infected Guinea Pig Model
[0030] Select Trichophyton mentagrophytes ( Trichophyton mentagrophytes ) ATCC4439 was used as a pathogenic bacterium, its virulence was recovered before the experiment, and it was inoculated on a sandcastle agar (SDA) slant test tube, cultured at 26°C, and the colonies were carefully scraped after 7-10 days, and the infectious fungal suspension was prepared with normal saline for later use . SDA consisted of 4% glucose, 1% peptone and 2% agar.
[0031] 36 healthy white guinea pigs, both male and female, weighing 250-350g. Cut short the long hairs on the abdomen and back of all white guinea pigs, and then remove the hair with a razor to make an 8cm×10cm hair removal area, and apply an appropriate amount of glycerin on the hair removal area to prevent the skin from drying out, and then rub the hair removal area repeatedly with sandpaper Skin, the damage...
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