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Preparation method of high-strength dual-mesh nano-meter titanium dioxide composite hydrogel

A technology of nano-titanium dioxide and composite hydrogel, applied in the field of preparation of high-strength double-network nano-composite hydrogel, to achieve the effect of improving mechanical strength

Inactive Publication Date: 2015-01-28
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the traditional sodium alginate / polyacrylamide double network hydrogel, it has a greater improvement

Method used

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  • Preparation method of high-strength dual-mesh nano-meter titanium dioxide composite hydrogel
  • Preparation method of high-strength dual-mesh nano-meter titanium dioxide composite hydrogel
  • Preparation method of high-strength dual-mesh nano-meter titanium dioxide composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Boil distilled water, seal and cool to room temperature to remove oxygen in the water, prepare a mass fraction of 1% nano TiO with cooled distilled water 2 Aqueous solution, nano TiO used 2 The particle size is 20-30nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0033] 2) Get sodium alginate and acrylamide and dissolve in the nano-TiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 10%;

[0034] 3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.03%, 0.1%, and 0.2% of the mass of acrylamide, respectively;

[0035] 4) Transfer the solution prepared in step 3) to a glass mold, seal it, place it at 45°C, and keep it war...

Embodiment 2

[0039] 1) Boil distilled water, seal and cool to room temperature to remove oxygen in the water, and prepare a mass fraction of 10% nano-TiO with cooled distilled water 2 Aqueous solution, nano TiO used 2The particle size is 90-100nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0040] 2) Get sodium alginate and acrylamide and dissolve in the nano-TiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 20%;

[0041] 3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.09%, 0.2%, and 0.3% of the mass of acrylamide, respectively;

[0042] 4) Transfer the solution prepared in step 3) to a glass mold, seal it, place it at 55°C, and keep i...

Embodiment 3

[0046] 1) Boil distilled water, seal and cool to room temperature to remove oxygen in the water, and prepare a mass fraction of 6% nano TiO with cooled distilled water 2 Aqueous solution, nano TiO used 2 The particle size is 40-50nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0047] 2) Get sodium alginate and acrylamide and dissolve in the nano-TiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 14%;

[0048] 3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.06%, 0.17%, and 0.25% of the mass of acrylamide, respectively;

[0049] 4) Transfer the solution prepared in step 3) to a glass mold, seal it, place it at 50°C, and keep ...

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Abstract

The invention discloses a preparation method of a high-strength dual-mesh nano-meter titanium dioxide composite hydrogel. The preparation method comprises the following steps: preparing a nanometer TiO2 water solution by using cooled boiling distilled water, dissolving sodium alginate, acrylamide, a crosslinking agent, an initiator and a catalyst in the TiO2 water solution, rapidly transferring the prepared solution into a glass mould, placing the sealed mould in an environment of a temperature of 45-55 DEG C for performing an insulation reactor for 2-6h; and taking hydrogel formed in the mould out and then dissolving the hydrogel in a CaCl2 water solution with a concentration of 0.1-1M for 2-6h, and taking out to obtain the high-strength dual-mesh nano-meter titanium dioxide composite hydrogel. Compared with a conventional hydrogel, the high-strength dual-mesh nano-meter titanium dioxide composite hydrogel disclosed by the invention is relatively high in strength and elongation so as to meet application demands of the high-strength dual-mesh nano-meter titanium dioxide composite hydrogel on aspects of human body cartilage repair, tissue engineering and the like.

Description

technical field [0001] The invention relates to the field of preparation of a high-strength hydrogel, in particular to the preparation of a high-strength double-network nanocomposite hydrogel. technical background [0002] Hydrogel is a kind of macromolecule or macromolecular aggregate with chemical or physical cross-linking structure, which can absorb a large amount of water but is insoluble in water. They can maintain a certain shape and three-dimensional space network structure in water. As a soft material with a water content of up to 90% and very similar to biological soft tissue, hydrogel is widely used in biological and medical fields, such as tissue engineering and cartilage repair. However, the mechanical strength of traditional hydrogels is far lower than that of natural biological tissues, which severely limits the clinical application of hydrogels. Therefore, narrowing the performance gap between polymer hydrogels and biological soft tissues, seeking polymer hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/00C08J3/075C08L51/02C08K3/22C08F251/00C08F220/56C08F222/38C08F222/14C08F212/36
Inventor 孟霞翟云鸽
Owner QILU UNIV OF TECH
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