Leukocyte-increasing traditional Chinese medicine decoction piece combined preparation as well as preparation method and combined package thereof

A technology of traditional Chinese medicine decoction pieces and white prescriptions, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2015-02-11
磐安县道地磐药中药研究所
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] Anti-tumor drugs are playing an increasingly important role in the current treatment of tumors. However, most of the current anti-tumor drugs inhibit or kill tumor cells, and at the same time, they are also toxic to normal cells in the body, especially bone marrow hematopoietic cells. and gastrointestinal mucosal epithelial cells
Therefore, in effective tumor treatment, toxic and side effects are almost inevitable, and some patients may be interrupted due to severe toxic and side effects or complications, so that some cancer p

Method used

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  • Leukocyte-increasing traditional Chinese medicine decoction piece combined preparation as well as preparation method and combined package thereof
  • Leukocyte-increasing traditional Chinese medicine decoction piece combined preparation as well as preparation method and combined package thereof

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specific Embodiment approach

[0057] The present invention is further illustrated below by means of examples, but the present invention is not limited to the scope of the examples.

[0058] Table 1 shows the raw materials and their contents of the combined preparations of Shengbai Fang traditional Chinese medicine decoction pieces of Examples 1-4, Comparative Examples 1-4 and Basic Examples.

[0059] The raw material of table 1 embodiment, comparative example and basic example and content thereof

[0060]

[0061] The preparation method of the Shengbaifang Chinese herbal medicine combination preparation of embodiment 1-4 and the product of comparative example 1-4 is:

[0062] Step 1: Grind epimedium, psoraleae, aconite, medlar, astragalus, atractylodes macrocephala and rehmannia glutinosa into 60-80 mesh fine powders, mix well, and soak in 80-90% ethanol that is 6-8 times the raw material 0.5 to 2 hours, heated and refluxed for 1 to 3 hours, extracted 1 to 3 times, filtered to remove medicinal residues...

Embodiment 5

[0070] The present invention also provides a combined package of a combined preparation of Shengbaifang traditional Chinese medicine decoction pieces, including Epimedium, Psoraleae, Aconite, Lycium barbarum, Astragalus, Caulis Spatholobus, Rubia, Angelica, Reed Rhizome, Ophiopogon japonicus, Licorice, Atractylodes macrocephala .

[0071] The package also includes auxiliary materials, including epimedium, psoraleae, aconite, medlar, astragalus, spatholobus, madder, angelica, reed rhizome, radix radix radix radices, licorice, Atractylodes macrocephala, rehmannia glutinosa, ginseng, scrophulariaceae, The ratio of the total amount of Tongcao to the auxiliary material is 1:1, and the auxiliary material is hydroxypropyl-β-cyclodextrin.

Embodiment 6

[0073] White blood cell phagocytosis test

[0074] Experimental principle: mix the white blood cells to be tested with staphylococci, and after incubating at 37°C for a certain period of time, the bacteria can be phagocytized by neutrophils. The number of leukocytes in phagocytes and the total number of phagocytized bacteria were calculated to calculate the phagocytosis rate and phagocytosis index, reflecting the phagocytosis function of neutrophils.

[0075] Materials: The equipment includes inoculation loops, small test tubes, micro-cell culture plates, water baths, glass slides, microscopes, etc. Preparation of bacteria solution: Take the lawn of Staphylococcus albus cultured on agar slant or plate for 24 hours, wash it twice with PBS (0.01mol / L pH6.5), and sterilize it in a boiling water bath for 15-20 minutes. Suspend the inactivated bacteria solution in 20% culture medium, adjust the cell concentration to 5*1000 / L by turbidimetry, and set aside at 4°C. 100U / ml heparin / ...

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Abstract

The invention relates to a preparation of traditional Chinese medicine decoction pieces, and particularly relates to a leukocyte-increasing traditional Chinese medicine decoction piece combined preparation as well as a preparation method and a combined package thereof. The preparation is prepared from the following raw materials in parts by weight: 10-15 parts of epimedium, 10-15 parts of fructus psoraleae, 5-10 parts of radix aconiti carmichaeli, 5-10 parts of fructus lycii, 5-10 parts of astragalus membranaceus, 3-8 parts of suberect spatholobus stem, 3-5 parts of rubia cordifolia, 3-5 parts of angelica sinensis, 1-3 parts of rhizoma phragmitis, 1-3 parts of radix ophiopogonis and 1-3 parts of licorice root. The preparation has the effects of warming kidneys and strengthening spleen, tonifying qi and blood, is used for treating patients with leukocytopenia due to spleen-kidney yang deficiency and qi-blood deficiency caused by cancer radiotherapy and chemotherapy, wherein leukocytopenia due to spleen-kidney yang deficiency and qi-blood deficiency has the syndromes of exhaust and fatigue, lack of energy, extreme chilliness, poor appetite and loose stool, soreness and weakness of waist and knees and the like. The preparation is capable of effectively increasing the content of leukocyte in blood, reducing the toxic and side effect of chemotherapy, and effectively improving the living quality of tumor patients.

Description

technical field [0001] The invention relates to a preparation of decoction pieces of traditional Chinese medicine, in particular to a combination preparation of decoction pieces of raw white prescription Chinese medicine, a preparation method and a combination package. Background technique [0002] Tumor is an abnormal lesion formed by the body under the action of various carcinogenic factors, a certain cell in the local tissue loses its normal regulation of its growth at the gene level, resulting in abnormal clonal proliferation. [0003] At present, chemotherapy is mostly used in the treatment of tumors. Chemotherapy is the abbreviation of chemical drug therapy. It is a treatment method that uses chemical drugs to prevent the proliferation, invasion, and metastasis of cancer cells, and finally kill cancer cells. It is a systemic treatment, together with surgery and radiotherapy, and is known as the three major treatment methods for cancer. Because the selectivity of chem...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P7/00A61P37/04
CPCA61K36/296A61K36/232A61K36/25A61K36/258A61K36/284A61K36/481A61K36/484A61K36/486A61K36/487A61K36/605A61K36/71A61K36/714A61K36/74A61K36/804A61K36/808A61K36/815A61K36/8945A61K36/8968A61K36/899A61K2236/15A61K2236/331A61K2236/333A61K2236/39
Inventor 傅苗青何雪心
Owner 磐安县道地磐药中药研究所
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