Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing andrographolide and use of pharmaceutical composition

A technology of andrographolide and neoandrographolide, which is applied in the field of medicine, can solve the problems of poor solubility of andrographolide and its derivatives, and achieve the effects of improving water solubility, good compatibility, and promoting human body absorption

Inactive Publication Date: 2015-02-18
刘芳
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of poor solubility of andrographolide and its derivatives, the invention provides a novel pharmaceutical composition containing andrographolide

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing andrographolide and use of pharmaceutical composition
  • Pharmaceutical composition containing andrographolide and use of pharmaceutical composition
  • Pharmaceutical composition containing andrographolide and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh andrographolide 97g, dehydroandrographolide 1g, deoxyandrographolide 0.5g, neoandrographolide 0.5g, isoandrographolide 0.5g, andrographolide 0.5g.

[0022] During preparation, the above-mentioned components are dissolved in hot ethanol, added into warm soybean oil under stirring, and ground by a colloid mill to prepare an ethanol soybean oil solution of andrographolide composition for later use, and an appropriate amount of soybean lecithin is mixed with water, and transferred Put it into a high-speed tissue masher (8000 rpm), stir three times, 3 minutes each time, to make it disperse evenly, add warm andrographolide composition ethanol soybean oil solution and stir for 15 minutes to make it into a primary emulsion, and Add water to make 1000ml, then transfer to a high-pressure milk homogenizer, homogenize for 3 to 6 times, make it uniform, potting, sterilizing, and packaging.

Embodiment 2

[0024] Weigh andrographolide 98g, dehydroandrographolide 0.3g, deoxyandrographolide 0.2g, neoandrographolide 0.5g, isoandrographolide 0.5g, andrographolide 0.5g.

[0025] During preparation, the above-mentioned components are dissolved in hot ethanol, added into warm soybean oil under stirring, and ground by a colloid mill to prepare an ethanol soybean oil solution of the andrographolide composition for future use. Take an appropriate amount of soybean lecithin and mix it with water, transfer it to a high-speed tissue masher (8000 rpm), stir three times, 3 minutes each time, to make it evenly dispersed, add warm andrographolide composition ethanol soybean oil solution and stir for 15 minutes. Minutes to make it into the first emulsion, and add water to make it into 1000ml, then transfer it to a high-pressure milk homogenizer, homogenize 2 to 5 times, make it uniform, potting, sterilizing, packaging, and it is ready.

Embodiment 3

[0027] Weigh andrographolide 99g, dehydroandrographolide 0.5g, deoxyandrographolide 0.2g, neoandrographolide 0.1g, isoandrographolide 0.1g, andrographolide 0.1g.

[0028] Preparation method: (1) adopt alcohol co-dissolution method, take prescription amount of andrographolide, dehydroandrographolide, deoxyandrographolide, neoandrographolide, isoandrographolide, andrographolide, hydroxypropyl-β- Cyclodextrin 800 g, add ethanol and heat to dissolve, stir, control the temperature below 45°C, stir for 4 hours, recover ethanol under reduced pressure, add appropriate amount of water to dissolve the solid, filter, and dry the filtrate under reduced pressure at 45°C to obtain andrographolide clathrate (2) Take the above-mentioned andrographolide clathrate, add water for injection to dissolve completely, adjust the pH value to 4-6, filter with a 0.22 μm filter membrane, and pot the filtrate to obtain andrographolide injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition containing andrographolide and a use of the pharmaceutical composition, and relates to a drug containing common andrographis herb, belonging to the technical field of medicines. The pharmaceutical composition containing andrographolide comprises the following components in parts by mass: 95-100 parts of andrographolide, 0-5 parts of andrographolide derivatives and the balance of pharmaceutically acceptable carriers. The pharmaceutical composition containing andrographolide disclosed by the invention has the effects of resisting bacteria, diminishing inflammation, resisting viruses, bringing down a fever, regulating the immunity and resisting tumors, can be used for restraining synthesis, release and inflammatory activity of the prostaglandin, and is mainly used for treating diseases such as bacillary dysentery, viral pneumonia, viral upper respiratory tract infection and acute tonsillitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to medicines containing andrographis paniculata, in particular to a pharmaceutical composition containing andrographolide and its application. Background technique [0002] Andrographis paniculata is the whole plant or leaf of Andrographis paniculata, the main component of which is andrographolide. Andrographolide is a diterpenoid compound, which has antibacterial, anti-inflammatory, antiviral, antipyretic, immune function and antitumor effects, and can inhibit the synthesis, release and inflammatory activity of prostaglandins. It is mainly used for bacillary dysentery, viral Pneumonia, viral upper respiratory tract infection, acute tonsillitis, etc. [0003] At present, SFDA has approved the production of andrographolide tablets, capsules, soft capsules, dropping pills and other oral dosage forms, but because andrographolide is a diterpene lactone compound, which is difficult to dissol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K31/365A61P31/04A61P31/12A61P11/00A61P11/04
CPCY02A50/30
Inventor 刘芳
Owner 刘芳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com