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Composite antibacterial material of graphene quantum dot and fibroin, preparation and application

A graphene quantum dot and silk protein technology, which is applied to composite materials for antibacterial, based on the field of graphene quantum dots and silk protein antibacterial composite materials, can solve the problems of heavy metal pollution, poor biocompatibility and high cost

Active Publication Date: 2015-02-18
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a composite material, preparation and application of graphene quantum dots and silk protein that can be used for antibacterial materials. The antibacterial composite material is a biophase Capacity, high efficiency, low cost, flexibility, controllable slow release, and easy preparation of graphene quantum dots and silk protein antibacterial composite materials are used to solve the problems of high cost, poor biocompatibility, and heavy metal pollution risks in existing antibacterial technologies. series of questions

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  • Composite antibacterial material of graphene quantum dot and fibroin, preparation and application
  • Composite antibacterial material of graphene quantum dot and fibroin, preparation and application

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preparation example Construction

[0088] Such as figure 1 Shown, the preparation method of described graphene quantum dot and silk protein antibacterial composite material at least comprises:

[0089] First, perform step S10: provide graphene quantum dots or doped graphene quantum dot aqueous solution;

[0090] Wherein, the graphene quantum dots in this step can be directly prepared by graphene oxide, specifically, the preparation method of the graphene quantum dots includes:

[0091] Step S11: providing graphene oxide powder;

[0092] In this step, the graphene oxide powder has no specific requirements. Preferably, the graphene oxide has a lateral dimension of 0.5-100 nm.

[0093] Step S12: adding a mixed solution of nitric acid and sulfuric acid to the graphene oxide powder and stirring to form a first mixed liquid;

[0094] Wherein, the concentration of the nitric acid in the mixed solution of the nitric acid and sulfuric acid is 50-80wt%, the concentration of the sulfuric acid is 50-98wt%, and the volu...

Embodiment 1

[0171] combine figure 1 , first, perform step S10: provide graphene quantum dot powder;

[0172] Specifically, in this embodiment, in this step, graphene oxide powder is provided, including:

[0173] Step S11: providing 5.00 g of graphene oxide powder;

[0174] Step S12: Add the graphene oxide powder into a mixture of 50 mL of concentrated nitric acid (67 wt%) and 120 mL of concentrated sulfuric acid (98 wt%), stir mechanically at 5°C for 60 min at a stirring rate of 1200 r / min, and form the first mixed liquid;

[0175] Step S13: Slowly add 60g of NaClO to the first mixed liquid 3 In order to generate an oxidation reaction, control the reaction temperature of the oxidation reaction to 0-5°C, and react for 12 hours to form a second mixed liquid;

[0176] Step S14: Cool the second mixed liquid to room temperature, add 200 mL of distilled water to dilute to form a third mixed liquid, and filter it with a 10 nm porous alumina filter;

[0177] Step S15: adding ammonia water to...

Embodiment 2

[0186] Select the graphene quantum dot powder obtained in step S16 in Example 1, carry out step S17, disperse the graphene quantum dots in the solvent, add B-containing dopant, solvothermal reaction, prepare B-doped graphene quantum dots .

[0187] Specifically, in this embodiment, take 0.5 g of the graphene quantum dot powder obtained in step S16, and ultrasonically disperse it in 10 mL of water, add 1.0 mL of dimethylaminoborane as a dopant to the dispersion, and place the mixed liquid in Lining a polytetrafluoroethylene reactor with a volume of 20mL, and placing the inner lining in a stainless steel reactor body, heating and reacting at 200°C for 24h.

[0188] Afterwards, step S18 is performed, and after the reaction, the reaction solution is filtered, dialyzed, and freeze-dried to obtain B-doped graphene quantum dot powder.

[0189] Specifically, in this example, the reaction liquid obtained in step S17 was cooled to room temperature, and filtered with a 10 nm porous alum...

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Abstract

The invention relates to a composite antibacterial material of graphene quantum dot and fibroin, preparation and application. The composite antibacterial material of graphene quantum dot and fibroin is characterized in that the mass ratio of the graphene quantum dot or doped graphene quantum dot to the fibroin is 1:1 to 1:10000; the doped graphene quantum dot is a non-metallic compound, a metallic compound or an organic compound, which contains a doping atom, has weak oxidization or reduction property, or is easy to coordinate; the concentration of a dopant is 0.01-10 mM; and the molecular weight of the fibroin is 1000-10000000 Da. The composite antibacterial material disclosed by the invention has the capability of greatly generating hydroxyl radicals having antibacterial capability under visible light or in a dark field; particularly, the composite material of B-doped graphene quantum dot and fibroin has excellent antibacterial capability; and thus, the composite antibacterial material used as an in-vivo antibacterial material or a wound suture material can be directly used in living bodies.

Description

technical field [0001] The invention relates to an antibacterial composite material, in particular to an antibacterial composite material, method and application based on graphene quantum dots and silk protein. The invention belongs to the technical field of biological antibacterial material preparation. Background technique [0002] Bacterial infection has always been an important problem that seriously affects human survival. Before the discovery of antibiotics, humans have been using extremely primitive methods to sterilize wounds inside or outside the body. How to design and manufacture new, efficient and safe antibacterial materials has always been a major issue that human beings are constantly striving to explore. Existing antibacterial methods are mainly divided into three categories: first, antibiotic drugs represented by penicillin and the like. The discovery of antibiotics has greatly improved the ability of humans to resist bacterial infections, and at the same ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/16
Inventor 丁古巧杨思维陶虎谢晓明江绵恒
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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