Surface-carboxylated fluorescent microspheres in crosslinked shell structure and preparation method thereof

A technology of fluorescent microspheres and cross-linked microspheres, applied in the field of fluorescent sensing materials, can solve the problems of limited application, instability, falling off, etc., and achieve the effects of convenient operation, stable structure and good dispersion performance.

Active Publication Date: 2015-02-25
SUZHOU UNIV
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Problems solved by technology

However, due to the inherent instability of layer-by-layer self-assembly, that is, when the solvent is not used properly, the polyelectrolyte adsorbed on the surface of microsphe

Method used

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  • Surface-carboxylated fluorescent microspheres in crosslinked shell structure and preparation method thereof
  • Surface-carboxylated fluorescent microspheres in crosslinked shell structure and preparation method thereof
  • Surface-carboxylated fluorescent microspheres in crosslinked shell structure and preparation method thereof

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Embodiment 1

[0019] This embodiment provides a polymer fluorescent microsphere with carboxyl groups on the surface and cross-linked by diazo resin. The preparation steps are as follows:

[0020] 1. Preparation of poly(p-phenylenevinylene) precursor salt solution

[0021] Referring to the literature Macromol. Rapid Commun. 2013, 34, 102-108, the synthesis of poly-p-phenylene vinylene precursor: the p-phenylene vinylene monomer was catalyzed in an oxygen-free environment and sodium hydroxide aqueous solution, and ice-water bath After reacting in the medium for one hour, dialyze with deionized water 5 to 6 times to obtain the aqueous solution of the poly(p-phenylenevinylene) precursor. Use a pipette gun to measure 2.5 mL of the aqueous solution of the poly(p-phenylenevinylene) precursor. Add 0.02925g of sodium chloride therein, shake and dissolve to obtain a colorless and transparent poly(p-phenylenevinylene) precursor salt solution.

[0022] 2. Preparation of diazo resin aqueous solution ...

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Abstract

The invention discloses surface-carboxylated fluorescent microspheres in a crosslinked shell structure and a preparation method thereof, belonging to the technical field of fluorescent sensing materials. The preparation method comprises the following steps: by using surface-sulfonated polystyrene-divinylbenzene crosslinked microspheres as the core, carrying out layer-by-layer self-assembly deposition on a p-phenylene ethylene precursor, poly(sodium-p-styrenesulfonate), diazo resin and polyacrylic acid on the core surface under the driving action of the electrostatic force, carrying out heat treatment, and carrying out crosslinking reaction on the diazo group and the carboxyl or sulfo group to generate the stable crosslinked shell structure, thereby obtaining the surface-carboxylated fluorescent microspheres. A layer-by-layer self-assembly process is adopted to modify the microsphere surface to introduce the carboxyl functional group with bioactivity, thereby simplifying the preparation technique. The method is convenient to operate and suitable for industrial production. The fluorescent microspheres have favorable dispersibility in water and multiple organic solvents, and can be applied to the fields of biological detection, medical diagnosis and the like.

Description

technical field [0001] The invention relates to a polymer fluorescent microsphere and a preparation method thereof, in particular to a surface carboxylated fluorescent microsphere with a crosslinked shell structure and a preparation method thereof, belonging to the technical field of fluorescent sensing materials. Background technique [0002] Compared with homogeneous fluorescent sensors, fluorescent microspheres have the advantages of easy deviceization, reusability, and no pollution to the system to be measured. As the specific surface area of ​​the sensing material increases, its sensitivity gradually increases. Compared with thin films, micro-nano-scale microspheres have a much larger specific surface area. When used as a carrier for a fluorescent sensor, the components to be measured and the sensor can fully contact, the sensitivity of the sensor is greatly improved. In particular, fluorescent nanospheres with controllable morphology, structure, and size are in great...

Claims

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Application Information

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IPC IPC(8): C09K11/06C09K11/02B01J13/02
Inventor 范丽娟邱钿
Owner SUZHOU UNIV
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