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Pharmaceutical composition for resisting endotoxic fever

An anti-endotoxin and composition technology, which is used in drug combinations, anti-infective drugs, pharmaceutical formulations, etc., to achieve the effects of exact curative effect, low price, and strict compatibility

Inactive Publication Date: 2015-03-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the current therapeutic drugs for acute bronchitis and chronic bronchitis in the acute exacerbation stage, most of them are western medicines that relieve symptoms, while there are few Chinese patent medicines that consider treating both symptoms and root causes.

Method used

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  • Pharmaceutical composition for resisting endotoxic fever

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: get 18g of Lithops vulgaris, 22g of Baiyunhua, 8g of Zelan, 5g of Cordyceps sinensis and add 12 times of 70% ethanol for reflux extraction 2 times, each time for 2 hours, merge the extracts, filter, and concentrate the filtrate under reduced pressure To thick extract, vacuum-dried, pulverized to obtain dry extract powder; prepared into tablets.

Embodiment 2

[0024] Embodiment 2: get 20g of Lithops vulgaris, 20g of Baiyunhua, 10g of Zelan, 4g of Cordyceps sinensis and add 12 times the amount of 70% ethanol for reflux extraction 2 times, each 2 hours, merge the extracts, filter, and the filtrate is concentrated under reduced pressure To thick extract, vacuum dry, pulverize to obtain dry extract powder; prepare into granules.

Embodiment 3

[0025] Embodiment 3: get 22g of Lithops vulgaris, 18g of Baiyunhua, 12g of Zelan, 3g of Cordyceps sinensis and add 12 times the amount of 70% ethanol for reflux extraction 2 times, each time for 2 hours, merge the extracts, filter, and the filtrate is concentrated under reduced pressure To thick extract, vacuum drying, pulverized to obtain dry extract powder, prepared into hard capsules.

[0026] 3. The effect of the present invention on the effect of endotoxin fever on the efficacy test data

[0027] 3.1 Materials

[0028] 3.1.1 Animals: Big-eared white rabbits, half male and half female, weighing 2.0-2.7kg, provided by Qinglongshan Animal Breeding Farm in Tangshan, Jiangning County, Nanjing, experimental animal production license SCXK (Su) 2002-0027, experimental animal use license : SYXK (Su) 2002-0008.

[0029] 3.1.2. Medicine: prepare granules of the present invention according to the method of Example 2, specification: 4g crude drug / g), acetaminophen tablet (paracetamo...

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PUM

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Abstract

The invention provides a pharmaceutical composition for resisting endotoxic fever. The composition is prepared from the following medicinal raw materials in parts by weight: 18-22 parts of coral lodiscus flabellata, 18-22 parts of heracleum rapula, 8-12 parts of herba lycopi and 3-5 parts of pungent litse fruit by adopting a corresponding preparation method. The medicinal raw materials are prepared into tablets, granules or hard capsules. The pharmaceutical composition has a function of resisting endotoxic fever, and is used for treating asthma, acute and chronic bronchitis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a medicinal composition for anti-endotoxin fever, a preparation method and an application. Background technique [0002] Bronchitis is generally divided into two types: acute and chronic. Acute bronchitis is an acute inflammation of the bronchial mucosa caused by Sendai virus or bacterial infection, physical, chemical stimulation or allergic reaction, and is generally a self-limiting disease. The main cause of chronic bronchitis is the chronic nonspecific inflammation of the bronchi caused by the repeated infection of Sendai virus and bacteria. When the temperature drops sharply, the spasm and ischemia of the small airway of the respiratory tract, and the defense function declines, it is conducive to pathogenesis; chronic stimuli such as smoke, dust, and polluted atmosphere can also cause the disease; smoking causes bronchospasm, mucosal variation, decreased...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P31/00A61P11/00
CPCA61K36/185A61K36/23A61K36/53A61K36/54A61K2236/333A61K2236/39
Inventor 卞毓平
Owner NANJING ZHENGLIANG MEDICAL TECH