Cefadroxil compound and pharmaceutical composition comprising same

A technology of cefadroxil compound and cefadroxil hydrate, applied in the field of cefadroxil compounds and pharmaceutical compositions thereof, can solve the problems of easy moisture absorption, limited application, poor solubility of cefadroxil, etc., and achieve uniform particle size , to avoid agglomeration, the effect of uniform particle size distribution
CN104447795AActive Publication Date: 2015-03-25金鸿药业股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
金鸿药业股份有限公司
Publication Date
2015-03-25

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a cefadroxil compound and pharmaceutical composition comprising the same. The cefadroxil compound is a cefadroxil hydrate with the molecular formula of C16H17N3O5S*3.5H2O, and the structural formula is shown in the specification. Various pharmaceutically-acceptable dosage forms can be prepared from the pharmaceutical composition comprising the cefadroxil compound, and chewable tablets and capsules are preferred. The cefadroxil compound has the advantage of capability of significantly improving the water solubility and the hygroscopicity of cefadroxil compounds.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a cefadroxil compound and a pharmaceutical composition thereof. Background technique

[0002] Cefadroxil, chemical name is (6R,7R)-3-methyl-7-[(R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-5-sulfur Hetero-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate, which is a well-known antibiotic with antibacterial activity, was developed by Briestol-Meyer, USA The second-generation oral cephalosporins have the characteristics of broad antibacterial spectrum, weak antigenicity, good curative effect, low toxicity and safe use.

[0003] At present, the cefadroxil products on the market are generally cefadroxil monohydrate, which is relatively stable in the external environment and easy to store. The molecular formula of cefadroxil monohydrate is C 16 h 17 N 3 o 5 S·H 2 O, molecular weight 381.41. The chemical structural formula of cefadroxil without water of...

Claims

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