Oxonantenine rare-earth complex as well as synthesis method and application thereof

A technology of rare earth complexes and nandinaphylline, which is applied in the field of oxidized nandinaphylline rare earth complexes and its synthesis, can solve blank problems and achieve good in vitro antitumor activity and superior in vitro antitumor activity

Inactive Publication Date: 2015-03-25
GUANGXI NORMAL UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, rare earth metal complexes using nantianaine as a ligand have not been reported at home and abroad, and the synthesis method and antitumor activity of such complexes are also blank.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxonantenine rare-earth complex as well as synthesis method and application thereof
  • Oxonantenine rare-earth complex as well as synthesis method and application thereof
  • Oxonantenine rare-earth complex as well as synthesis method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Synthesize ONT-Nd with normal pressure solution method Ⅲ Complex

[0040] Take 1mmol Nd(NO 3 ) 3 .6H 2 O was dissolved in 5mL of methanol; 2mmol of ONT was heated and dissolved in 15mL of methanol. The two solutions were mixed and reacted at 70°C (reflux) for 1 hour. After the reaction, a red suspension was obtained with a large number of complexes. A solid was formed; the solution was filtered, and the filtered solid was washed with water, methanol, and ether in turn, and dried to obtain a dark red solid product. The crimson product that this embodiment gained is through infrared spectrum (collection as shown in FIG. figure 1 shown), high-resolution mass spectrometry (spectrum as shown in figure 2 shown) and X single crystal diffraction (pattern as image 3 Shown) analysis, confirm that the dark red solid product obtained is the target complex [Nd(ONT) 2 (NO 3 ) 3 ].

Embodiment 2

[0041] Embodiment 2: Synthesize ONT-Gd with normal pressure solution method Ⅲ Complex

[0042] 1mmol Gd(NO 3 ) 3 .6H 2 O was dissolved in 10mL of water; 2mmol of ONT was dissolved in 50mL of ethanol. The two solutions were mixed and reacted at 60°C (reflux) for 10 hours. After the reaction, a red suspension was obtained, and a large amount of complex solids were formed. ; The solution was filtered, and the filtered solid was washed with water, ethanol and ether in turn, and dried to obtain a red solid product. The crimson product that this embodiment gained is through infrared spectrum (collection as shown in FIG. Figure 4 shown), electrospray mass spectrometry (spectrum as shown in Figure 5 shown) and X single crystal diffraction (pattern as Figure 6 Shown) analysis, it is determined that the obtained deep red solid product is the target complex [Gd(ONT) 2 (NO 3 ) 3 ].

Embodiment 3

[0043] Embodiment 3: Synthesize ONT-Tb with normal pressure solution method Ⅲ Complex

[0044] 1mmol Tb(NO 3 ) 3 .6H 2 O was dissolved in 50mL of water; 2mmol of ONT was dissolved in 200mL of acetone, and the two solutions were mixed and reacted at 80°C (reflux for condensation) for 20 hours. After the reaction, a red clear solution was obtained; most of them were removed by distillation under reduced pressure Solvent, a large amount of complex solids were precipitated, after cooling, the solution was filtered, and the filtered solids were washed with water, ethanol, and ether in turn, and dried to finally obtain a red solid product. The crimson product that this embodiment gained is through infrared spectrum (collection as shown in FIG. Figure 7 shown), high-resolution mass spectrometry (spectrum as shown in Figure 8 shown) and X single crystal diffraction (pattern as Figure 9 Shown) analysis, it is determined that the dark red solid product obtained is the target co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an oxonantenine rare-earth complex as well as a synthesis method and an application thereof. The rare-earth complex is obtained from a coordination reaction between oxonantenine which serves as a ligand and rare-earth metal salt in a polar solvent, and specifically, the rare-earth complex can be synthesized by virtue of a solution method or a solvothermal method. By investigating the inhibitory effect of the complex on the growth of multiple tumor cell strains, the applicant discovers that the rare-earth complex shows better antitumor activity in vitro than that of cis-platinum as a classical metal-based anti-cancer drug; meanwhile, some rare-earth complex also shows better antitumor activity in vitro than that of an oxonantenine ligand; and therefore, the rare-earth complex has a potential medicinal value, and is expected to be used for preparing various anti-cancer drugs. The structure of the rare-earth complex is as shown in formula I (as shown in Specification).

Description

technical field [0001] The invention relates to the field of metal coordination compounds, in particular to oxidized nandinaphyllin rare earth complexes and their synthesis methods and applications. Background technique [0002] Cancer is one of the most serious diseases that endanger human health. With the development of society and the deterioration of modern lifestyle and living environment, various carcinogenic factors such as genetics, environmental pollution, passive smoking, toxic and side effects of drugs, radiation, viruses, etc. , leading to an increase in the incidence of cancer in today's society. The most common and serious malignant tumors are: breast cancer, cervical cancer, lymphoma, leukemia, lung cancer, liver cancer and other types. For a long time, platinum-based drugs have been the most widely used complex small-molecule anticancer drugs. However, their clinical application is limited due to their high toxicity and side effects and easy drug resistance. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61K31/555A61P35/00
CPCC07F5/003
Inventor 陈振锋梁宏刘延成曹东张业黄克斌
Owner GUANGXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap