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Production method of nicotinic acid

A production method and technology of nicotinic acid, which is applied in the direction of fermentation, etc., can solve the problems of environmental pollution, serious equipment corrosion, high equipment requirements, etc., and achieve the effects of product stability, extended service life, and simple operation

Inactive Publication Date: 2015-03-25
XUZHOU HENGDING BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many production methods of nicotinic acid. The ammonia oxidation method and the nitric acid oxidation method are mostly used in industry. These two methods have high requirements on equipment, and strong oxidants will cause serious corrosion of equipment, and will also produce a large amount of industrial wastewater, causing environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In the embodiment of the present invention, weigh 6 g of 4-cyanopyridine, 20 g of deionized water, and 0.5 g of cyanohydrolase, respectively, place 4-cyanopyridine in a container, then add deionized water into the container, and stir to form Aqueous solution of 4-cyanopyridine. Heat the aqueous solution of 4-cyanopyridine to 45° C., add cyanohydrolase, and react at 45° C. with stirring for 2 hours to catalyze the hydrolysis of 4-cyanopyridine to generate nicotinic acid solution. The nicotinic acid solution was placed in a vacuum distillation device for vacuum distillation at a pressure of 0.3 kPa, a temperature of 60° C., and a vacuum distillation time of 4 hours to obtain a concentrated solution. Put the concentrated solution in an oven and bake at 90°C for 10 hours to obtain niacin with a water content of 0.5%. Put niacin with a water content of 0.5% into an extruder, and press it into a niacin tablet with a thickness of 0.5 mm under a pressure of 5 MPa. The nicotin...

Embodiment 2

[0020] In the embodiment of the present invention, weigh 6.25 g of 4-cyanopyridine, 22.5 g of ethanol, and 0.8 g of cyanohydrolase, respectively, place 4-cyanopyridine in a container, add ethanol, and stir to form 4-cyanopyridine of aqueous solution. Heat the aqueous solution of 4-cyanopyridine to 48°C, add cyanohydrolase, and react at 48°C with stirring for 1.8h, and catalyze the hydrolysis of 4-cyanopyridine to generate nicotinic acid solution. The nicotinic acid solution was placed in a vacuum distillation device for vacuum distillation at a pressure of 1 kPa, a temperature of 75° C., and a vacuum distillation time of 2 hours to obtain a concentrated solution. Put the concentrated solution in an oven and bake at 100°C for 8 hours to obtain niacin with a water content of 1%. Put niacin with a water content of 1% into an extruder, and press it into a niacin tablet with a thickness of 0.8mm under a pressure of 6.5MPa. The nicotinic acid tablet was crushed, and sieved by an 8...

Embodiment 3

[0022] In the embodiment of the present invention, weigh 6.5 g of 4-cyanopyridine, 25 g of methanol, and 1 g of cyanohydrolase, respectively, place 4-cyanopyridine in a container, add methanol, and stir to form an aqueous solution of 4-cyanopyridine . Heat the aqueous solution of 4-cyanopyridine to 50°C, add cyanohydrolase, and react at 50°C with stirring for 1.5h, and catalyze the hydrolysis of 4-cyanopyridine to generate nicotinic acid solution. The nicotinic acid solution was placed in a vacuum distillation device for vacuum distillation at a pressure of 3 kPa, a temperature of 90° C., and a vacuum distillation time of 0.5 h to obtain a concentrated solution. Put the concentrated solution in an oven and bake at 110°C for 6 hours to obtain niacin with a water content of 2%. Put niacin with a water content of 2% into an extruder, and press it into a niacin tablet with a thickness of 1 mm under a pressure of 8 MPa. The nicotinic acid tablet was crushed, and sieved by an 80-m...

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Abstract

The invention discloses a production method of nicotinic acid. The production method comprises the following steps: adding 4-cyanopyridine and de-ionized water to a container, and stirring to obtain a liquid; heating and warming up, adding nitrilase and carrying out a reaction to obtain a nicotinic acid liquid; and decompressing and distilling to obtain a concentrated liquid, drying, tabletting and breaking the concentrated liquid to obtain nicotinic acid particles. According to the production method disclosed by the invention, the content of the nicotinic acid prepared by virtue of the nitrilase is above 95%, and meanwhile the production method is mild in reaction condition, stable in product, simple to operate and easy to implement. The production method disclosed by the invention is free from materials corrosive to equipment during preparation, so that the service life of the equipment is prolonged; and the production method is free from pollution to environment, and is especially suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a production method of niacin. Background technique [0002] Niacin is also known as vitamins B3, or vitamin PP, molecular formula : C6H5NO2, heat-resistant, energy sublimation . Nicotinic acid, also known as nicotinic acid, anti Leprosy factor. In the human body, it also includes Derivative Niacinamide or nicotinamide. It is 13 essential for the human body vitamins one of a kind water soluble vitamins ,belong Vitamin B complex . Niacin is converted in the body to Nicotinamide , nicotinamide is coenzyme I and Coenzyme II Components involved in lipid metabolism in vivo, oxidation process of tissue respiration and carbohydrate The process of anaerobic decomposition. [0003] There are many production methods of nicotinic acid, and ammonia oxidation and nitric acid oxidation are mostly used in industry. These two methods have high requirements on equipment, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/12
Inventor 应国海喻淼王辉曹云峰苏毅任河毅
Owner XUZHOU HENGDING BIOTECH
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