A compound with antibacterial activity and preparation method and application of water-soluble liquid thereof

A technology for bacteriostatic activity and compound is applied in the field of preparation of compounds and water-soluble liquid preparations thereof, and can solve the problem that the bacteriostatic activity of N-(4-isopropylbenzoyl)-4-methylpiperidine is unknown. The use of chemical compounds and other problems can achieve the effect of good control effect, good environmental compatibility and simple structure.

Inactive Publication Date: 2016-10-05
XIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report on the use of N-(4-isopropylbenzoyl)-4-methylpiperidine as an antibacterial active compound

Method used

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  • A compound with antibacterial activity and preparation method and application of water-soluble liquid thereof
  • A compound with antibacterial activity and preparation method and application of water-soluble liquid thereof
  • A compound with antibacterial activity and preparation method and application of water-soluble liquid thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of compound N-(4-isopropylbenzoyl)-4-methylpiperidine

[0029] Add 0.01mol p-isopropylbenzoic acid and 15mL thionyl chloride to a 50mL three-neck flask, heat to 80°C and reflux for 2 hours, distill off excess thionyl chloride until no liquid flows out, and cool to At room temperature, p-isopropylbenzoyl chloride can be obtained.

[0030] Add 0.01mol 4-methylpiperidine and 10mL dichloromethane into a 50mL three-necked flask, add 3mL pyridine or triethylamine, and add freshly prepared p-isopropylbenzoyl chloride dropwise while stirring at room temperature. After the dropwise addition, continue the reaction at 30-50°C for 5 hours. After the reaction is complete, wash the reaction mixture with 10% hydrochloric acid, 10% NaOH and distilled water to neutrality, and place it in a refrigerator at 2-6°C until the solid precipitates Afterwards, filtered, washed, and recrystallized with absolute ethanol to obtain a white solid product with a yield of 81%. The spectra...

Embodiment 2

[0034] Preparation of 5% N-(4-isopropylbenzoyl)-4-methylpiperidine water-soluble solution

[0035] Weigh 5kg of N-(4-isopropylbenzoyl)-4-methylpiperidine into 86.99kg of ethylene glycol, add 0.01kg of dibutyl phthalate, stir at a constant temperature of 30°C, slowly Add 8 kg of Tween-20 until the solution is completely clear and transparent, and then stir at constant temperature for 20 minutes to obtain a 5% N-(4-isopropylbenzoyl)-4-methylpiperidine water-soluble liquid.

Embodiment 3

[0037] Preparation of 10% N-(4-isopropylbenzoyl)-4-methylpiperidine water-soluble solution

[0038] Weigh 10kg of N-(4-isopropylbenzoyl)-4-methylpiperidine into 74.99kg of diethylene glycol, add 0.01kg of dibutyl phthalate, stir at a constant temperature of 50°C, slowly Add 15kg of OP-7 until the solution is completely clear and transparent, and then stir at constant temperature for 30 minutes to obtain a 10% N-(4-isopropylbenzoyl)-4-methylpiperidine water-soluble liquid.

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Abstract

The invention discloses preparation methods and application of a compound with antibacterial activity and water-soluble liquid thereof, and relates to the field of pesticides. The compound is N-(4-isopropyl benzoyl)-4-methylpiperidine, and the structural formula of the compound is the formula (I) shown in the description. The preparation method of the compound comprises the following steps: enabling 4-isopropyl benzoic acid to react with thionyl chloride under a heating reflux condition to obtain p-isopropyl benzoyl chloride; adding a catalyst, namely, pyridine or triethylamine into 4-methylpiperidine and dichloromethane; agitating under the room temperature; dropwise adding p-isopropyl benzoyl chloride to react; filtering, washing and recrystallizing to obtain a white solid namely the compound. The compound has excellent inhibitory activity for bipolaria maydis, sclerotinia sclerotioru, botrytis cinerea and other plant pathogenic fungi; in addition, an emulsifier, an anti-foaming agent and a solvent can be added into the compound to prepare into the water-soluble liquid and other pesticide preparations for developing and application.

Description

technical field [0001] The invention relates to the field of pesticides, in particular to a preparation method and application of a compound with antibacterial activity and its water-soluble liquid. Background technique [0002] As we all know, the long-term and large-scale use of pesticides not only pollutes the environment and destroys the ecological balance, but also has serious "3R" (residue, resistance, and rampant pests and diseases) and "three causes" (carcinogenic, teratogenic, and mutagenic) problems. . These problems have aroused widespread concern of mankind, and how to effectively solve them is a long-term and arduous task facing mankind. In this way, under the situation that pesticides are facing huge challenges, and human beings cannot do without pesticides, it is necessary to look for products that are highly effective for harmful organisms, safe for non-target organisms, easy to degrade in the environment, and the degradation products are safe for human heal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D211/16A01N43/40A01N25/02A01P3/00
CPCA01N25/02A01N43/40C07D211/16
Inventor 唐孝荣杨建王雪松高素美高扬徐志宏张燕王玲
Owner XIHUA UNIV
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