2-Amino-7-substituted benzothiazole compounds, preparation method and use thereof

A technology of benzothiazole and compounds, applied in the field of medicinal chemistry, can solve the problems of high cost, high medical expenses, and unsatisfactory effects, and achieve the effects of simple post-processing, high yield, and short reaction steps

Active Publication Date: 2016-07-06
ZHANGZHOU PIEN TZE HUANG PHARM
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hepatitis and liver cancer patients suffer from serious diseases all the year round, and the medical expenses are extremely high. Currently, the interferon, interleukin and antiviral drugs used to treat hepatitis and liver cancer are expensive, but the effect is not satisfactory, which causes economic losses to individuals and society. Therefore, it is of great significance to develop new drugs for the treatment of hepatitis and liver fibrosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 2-Amino-7-substituted benzothiazole compounds, preparation method and use thereof
  • 2-Amino-7-substituted benzothiazole compounds, preparation method and use thereof
  • 2-Amino-7-substituted benzothiazole compounds, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The synthesis of embodiment 12-amino-7 trifluoromethylmercaptobenzothiazole

[0057] Dissolve 0.01mmol of 3-trifluoromethylmercaptoaniline in 10mL of acetic acid, add 30mmol of potassium thiocyanate and stir for 25 minutes. 13 mmol of bromine was dissolved in 0.7 mL of acetic acid, slowly added to the above-mentioned reactant, the reaction temperature in a water bath was 20°C, stirred overnight, filtered, and the precipitate was washed 3 times with 25 mL of ethyl acetate. Combine the filtrate and washing liquid, alkalinize it with ammonia solution, wash twice with 120mL concentrated brine, concentrate to 20mL, apply flash chromatography, and elute with n-hexane: acetone 5:1-4:1 (v / v). The eluate was collected and the solvent was evaporated to obtain 1.38 g of 2-amino-7-trifluoromethylmercaptobenzothiazole with a yield of 55%. 1 H-NMR (CDCl 3 , 500MHz), 4.14(brs, 2H), 6.79(dd, J=8.5Hz, J=2.5Hz, 1H), 7.06(d, J=2.5Hz, 1H), 7.54(d, J=8.0Hz, 1H ); ESI-MS (m / z, %): 249.26 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of medicine chemistry, and particularly relates to a 2-amino-7-substituted benzothiazole compound as well as a preparation method and application thereof. The 2-amino-7-substituted benzothiazole compound can be used for remarkably inhibiting synthesis of activated rat liver star-shaped cell collagen I type and extracellular matrix and regulating the expression of relevant synthetic gene and enzyme, has an obvious inhibition effect on generation of mouse liver fibrosis model cell periplasm, and can be used as a medicine for resisting hepatitis and liver fibrosis. The preparation method of the 2-amino-7-substituted benzothiazole compound adopts raw materials which are wide in source, and is short in reaction steps, simple and convenient in after-treatment and relatively high in yield.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to 2-amino-7-substituted benzothiazole compounds and a preparation method and application thereof. Background technique [0002] Liver disease is one of the diseases that seriously threaten human health. According to the etiology, it can be roughly divided into infectious liver disease and non-infectious liver disease. Infectious liver diseases include: hepatitis B (HBV), hepatitis C (HCV) and hepatitis D (HDV), liver diseases caused by schistosomiasis, etc.; non-infectious liver diseases include: congenital metabolic defects (hepatolenticular degeneration , hemochromatosis, α1-antitrypsin deficiency, etc.), liver disease caused by chemical metabolic defects (chronic alcoholic liver disease, chronic drug-induced liver disease), autoimmune hepatitis, primary liver cirrhosis , Primary sclerosing cholangitis, etc. [0003] According to statistics, hepatitis is one of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D277/82A61K31/428A61P1/16A61P31/14A61P31/20
CPCC07D277/82
Inventor 黄进明陈志亮曾金香殷婷婷
Owner ZHANGZHOU PIEN TZE HUANG PHARM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap