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Intervertebral disc imitating spine fuser and preparing method thereof

A spinal fusion and intervertebral disc imitation technology, applied in the direction of fixator, internal fixator, internal bone synthesis, etc., can solve the problems such as difficulty in forming hydroxyapatite into a scaffold, difficulty in forming a cellulose scaffold, and difficulty in controlling the degradation rate, etc. Good clinical use effect, convenient operation, and the effect of reducing the pain of operation

Inactive Publication Date: 2015-04-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxyapatite is difficult to form a scaffold alone and degrades very slowly in vivo
Magnesium metal stents, the degradation rate is difficult to control, and the structure will be damaged due to rapid corrosion after implantation
Cellulose scaffolds are difficult to form and the degradation cycle is difficult to control

Method used

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  • Intervertebral disc imitating spine fuser and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] 1) Weigh 9 grams of chitosan powder, add it to 300 milliliters of 2% acetic acid aqueous solution, and stir mechanically for 2 hours to obtain a uniform and transparent chitosan solution. Pour it into a ring-shaped mold, immerse in a 3% sodium hydroxide aqueous solution for 2 hours to gel, wash and dry to obtain a ring-shaped cylindrical stent;

[0022] 2) Weigh 1g of chitosan and dissolve it in 100g of 2% acetic acid aqueous solution, prepare a 1% chitosan acetic acid solution, fill it into the inner cylinder of the annular cylindrical stent, and gel it with 3% sodium hydroxide melted, washed with water, and freeze-dried at -20°C to obtain a chitosan porous structure core layer with a porosity of 95% and a pore diameter of 500 μm;

[0023] 3) Dissolve interferon and bone morphogenetic protein in PBS solution, then add nano-hydroxyapatite to obtain a mixed dispersion, so that the concentration of interferon in the mixed dispersion is 10ng / mL, and the concentration of bo...

example 2

[0026] 1) Weigh 15 grams of chitosan powder, add it to 300 ml of 3% acetic acid aqueous solution, and stir mechanically for 2 hours to obtain a uniform and transparent chitosan solution. Pour it into a ring-shaped mold, immerse in a 3% sodium hydroxide aqueous solution for 2 hours to gel, wash and dry to obtain a ring-shaped cylindrical stent;

[0027] 2) Weigh 3g of chitosan and dissolve it in 100g of 2% acetic acid aqueous solution to prepare a 3% chitosan acetic acid solution, fill it into the inner cylinder of the annular cylindrical support, and then solidify it with 4% sodium hydroxide. Gelling, washing with water, and freeze-drying at -40°C to obtain a chitosan porous structure core layer with a porosity of 90% and a pore diameter of 350 μm;

[0028] 3) Dissolve interferon and bone morphogenetic protein in PBS solution, then add nano-hydroxyapatite to obtain a mixed dispersion, so that the concentration of interferon in the mixed dispersion is 100ng / mL, and the concentr...

example 3

[0031] 1) Weigh 20 grams of chitosan powder, add it to 300 milliliters of 4% acetic acid aqueous solution, and stir mechanically for 2 hours to obtain a uniform and transparent chitosan solution. Pour it into a ring-shaped mold, immerse in a 5% sodium hydroxide aqueous solution for 2 hours to gel, wash and dry to obtain a ring-shaped cylindrical stent;

[0032] 2) Weigh 5g of chitosan and dissolve it in 100g of 3% acetic acid aqueous solution, prepare a 5% chitosan acetic acid solution, fill it into the inner cylinder of the annular cylindrical stent, and gel it with 5% sodium hydroxide melted, washed with water, frozen at -40°C, and dried to obtain a chitosan porous structure core layer with a porosity of 85% and a pore diameter of 270 μm;

[0033] 3) Dissolve interferon and bone morphogenetic protein in PBS solution, then add nano-hydroxyapatite to obtain a mixed dispersion, so that the concentration of interferon in the mixed dispersion is 300ng / mL, and the concentration of...

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Abstract

The invention discloses an intervertebral disc imitating spine fuser and a preparing method thereof. An inner cylinder of an annular cylindrical support is filled with a core layer. Locating blind holes are formed in the upper surface and the lower surface of the annular cylindrical support. A magnesium wire is embedded on the outer periphery of the annular cylindrical support. The annular cylindrical support is made of chitosan with the porosity of 0%-40%. The core layer is of a chitosan mult-hole structure with the hole diameter of 50-500 microns and the porosity of 60%-95%. Interferon, bone morphogenetic protein and nanometer hydroxyapatite composite are arranged on a hole wall of the multi-hole structure. The intervertebral disc imitating spine fuser is used as a fusion support in an intervertebral fusion operation, an autogenous bone and an allograft bone are of no need, bone fusion is induced quickly, the support can be degraded safely, and secondary operation is of no need.

Description

Technical field [0001] The present invention involves a degradable imitation imitation of the intervertebral diabet spine fusion and its preparation methods with the ability to induce bone. Background technique [0002] The most effective method for clinical treatment of lumbar intervertebral discylinal lesions is intervertebral fusion.That is, artificially implanted the support bracket, and then placed autologous bones or same alien bones in the bracket to induce the spine to fusion. [0003] At present, the intervertebral fusion that has been used clinically has no bone induction and degradability.The patient's autologous bone pain is extremely painful, and it is difficult to obtain the pathway of the same type of alien bone.The fusion is not degraded, making patients suffer secondary pain, and the risk of inflammatory infection increases. [0004] Bio-degradable stent materials that have been developed and clinically trials are polymapilic acid (PLA), hydroxylhhexylite (HA), m...

Claims

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Application Information

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IPC IPC(8): A61F2/44A61B17/70A61L27/22A61L27/20A61L27/12A61L27/56
Inventor 胡巧玲庞艺川王征科
Owner ZHEJIANG UNIV
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