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Vitamin B6 composition freeze-dried tablet and preparation method thereof

A vitamin and composition technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of good formability, improved adhesion, and high bioavailability

Inactive Publication Date: 2015-04-22
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient Production of vitamin B by freeze-drying process 6 Freeze-dried tablets have not been reported

Method used

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  • Vitamin B6 composition freeze-dried tablet and preparation method thereof
  • Vitamin B6 composition freeze-dried tablet and preparation method thereof
  • Vitamin B6 composition freeze-dried tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026]

[0027] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, and use a pH regulator to control the pH of the solution at 6.5 , and then heated to 72°C for 120 minutes to make a 9% (W / V) cornstarch solution.

[0028] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0029] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0030] D. Weigh vitamin B 6 10g, added to 1L corn-sucrose solution, stirred for 30 minutes.

[0031] E, liquid determination of vitamin B 6 After content, the medicinal solution is ...

Embodiment 2

[0034]

[0035] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, and use a pH regulator to control the pH of the solution at 4-5 , and then heated to 72°C for 120 minutes to make a 13% (W / V) cornstarch solution.

[0036] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0037] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0038] D. Weigh vitamin B 6 10gram (Based on 1000 pieces) , add 1L of corn-sucrose solution and stir for 30 minutes.

[0039] E, liquid determination of vitamin B 6 After content,...

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Abstract

Relating to the technical field of medicine and medicine production, the invention provides a vitamin B6 composition freeze-dried tablet and a preparation method thereof. The freeze-dried tablet contains vitamin B6, starch and sucrose. The starch and sucrose are used as auxiliary materials. Heating process treatment is carried out on ordinary corn starch to improve the bonding and disintegrating effects of starch in the tablet and improve the formability of the tablet. The vitamin B6 composition freeze-dried tablet only needs starch and sucrose as the auxiliary materials. The vitamin B6 composition freeze-dried tablet adopts a freeze-drying process of two-cooling and two-heating. Two cooling and two heating enable better formability of the tablet, and enhance the dissolution of the tablet, thereby improving the bioavailability of the tablet. The tablet overcomes the disadvantages of common vitamin B6 tablets, and reduces the variety and dosage of auxiliary materials in vitamin B6 tablets. The tablet provided by the invention has high dissolution and bioavailability, and ensures the efficacy and safety of clinical medication.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a vitamin B 6 Composition freeze-dried tablet and its preparation method. Background technique [0002] Molecular formula C 8 h 11 NO 3 ·HCl [0003] Molecular weight 205.64 [0004] It mainly participates in nearly a hundred enzyme reactions in the form of pyridoxal phosphate (PLP). Most are related to amino acid metabolism: including transamination, decarboxylation, side chain cleavage, dehydration and transsulfurization. Participate in the conversion of homocysteine ​​to methionine, which has the effect of reducing chronic diseases. Mild hyperhomocysteinemia is considered a possible risk factor for vascular diseases. Vitamin B 6 intervention can reduce plasma homocysteine ​​levels. The commonly used clinical dosage forms are tablets and injections. [0005] common vitamin B 6 Tablets contain many types and quantities of excipients. Generall...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4415A61K47/36A61K47/26
Inventor 储旦旦汪金灿郝结兵吴函峰汪志琼
Owner HAINAN WEI KANG PHARMA QIANSHAN
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