Apixaban tablet and preparation method thereof
A technology for apixaban tablets and excipients, applied in the field of apixaban tablets and its preparation, can solve the problems of low in vitro dissolution rate, low bioavailability, slow dissolution rate, etc., and achieve simple preparation process, The effect of high bioavailability and low packaging cost
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Embodiment 1
[0028] Components of Apixaban Tablets
[0029] components
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
Apixaban
10
20
30
microcrystalline fiber
38
76
114
anhydrous lactose
70
140
210
Crosslinked Cellulose Sodium
2
4
6
Sodium dodecyl sulfate
2
4
6
Magnesium stearate
0.2
0.4
0.6
[0030] Preparation Process:
[0031] (1) Weigh the raw and auxiliary materials of the above prescription amount, except for magnesium stearate, mix all the raw and auxiliary materials and carry out wet granulation. The soft material obtained is granulated with a 20-mesh sieve, and the obtained granules are dried and granulated. Granules, and finally collect dry particles between 20 mesh and 80 mesh.
[0032] (2) After mixing the prepared granules with magnesium stearate for 30 minutes, press into tablets, and the hardness of the tablets is 50-60N.
Embodiment 2
[0034] Apixaban Tablet Ingredients
[0035] components
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
Apixaban
10
20
40
powdered sugar
60
120
250
microcrystalline fiber
22
40
88
Crospovidone
3
6
16
Sodium dodecyl sulfonate
2
4
6
Magnesium stearate
0.2
0.4
0.6
[0036] Preparation Process:
[0037] (1) Weigh the raw and auxiliary materials of the above prescription amount, except for magnesium stearate, mix all the raw and auxiliary materials and carry out wet granulation. The soft material obtained is granulated with a 20-mesh sieve, and the obtained granules are dried and granulated. Granules, and finally collect dry particles between 20 mesh and 80 mesh.
[0038] (2) After mixing the prepared granules with magnesium stearate for 30 minutes, press into tablets, and the hardness of the tablets is 50-60N.
Embodiment 3
[0040] Components of Apixaban Tablets
[0041]
[0042] Preparation Process:
[0043] (1) Weigh the raw and auxiliary materials of the above prescription amount, except for magnesium stearate, mix all the raw and auxiliary materials and carry out wet granulation. The soft material obtained is granulated with a 20-mesh sieve, and the obtained granules are dried and granulated. Granules, and finally collect dry particles between 20 mesh and 80 mesh.
[0044] (2) After mixing the prepared granules with magnesium stearate for 30 minutes, press into tablets, and the hardness of the tablets is 50-60N.
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