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Microspheres and their application in wound hemostasis

A technology of microspheres and sodium alginate, applied in the field of microspheres, can solve the problems of high price and unpopularity, and achieve the effects of high adhesion rate, promoting adhesion and improving cross-linking degree.

Active Publication Date: 2017-09-15
ZHEJIANG SANCHUANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the Arista hemostatic microspheres imported from the United States (RMB 2,000 per bag, water absorption ≥ 10) and the CELOX hemostatic gauze imported from the United Kingdom that have been sold in China are expensive and are only sold in hospitals in urban centers such as Beijing, Shanghai, and Guangzhou. The market is very unpopular

Method used

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  • Microspheres and their application in wound hemostasis
  • Microspheres and their application in wound hemostasis
  • Microspheres and their application in wound hemostasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 1.5g of sodium alginate, 0.5g of carboxymethyl chitosan and 0.025g of collagen into 100ml of water and dissolve to prepare a matrix solution.

[0038] Mix 250ml of liquid paraffin with 18.75ml of Tween 80, add matrix solution, and 10ml of 2w / w% calcium chloride, accompanied by rapid stirring, to carry out cross-linking reaction to prepare microspheres.

[0039] After the end, add 500ml of ethanol and soak for 2 hours. After the microspheres and the solution are separated, remove the clear liquid, filter the precipitate to further remove the excess solution, and put it in a vacuum drying oven at 60°C for drying. The morphology of the dried microspheres under the electron microscope is as follows: figure 1 As shown, the particle size distribution of more than 90% of the microspheres is between 10 μm and 100 μm as detected by the laser diffraction particle size analyzer.

Embodiment 2

[0041] Add 1.0 g of sodium alginate, 0.5 g of carboxymethyl chitosan and 0.025 g of collagen into 100 ml of water and dissolve to prepare a matrix solution.

[0042] Mix 250ml of soybean oil with 18.75ml of Tween 60, add matrix solution, and 10ml of 4w / w% calcium chloride, accompanied by rapid stirring, to carry out cross-linking reaction to prepare microspheres.

[0043] After the end, add 500ml of ethanol and soak for 2 hours. After the microspheres and the solution are separated, remove the clear liquid, filter the precipitate to further remove the excess solution, and put it in a vacuum drying oven at 60°C for drying. The dried microspheres are detected by a laser diffraction particle size analyzer, and the particle size distribution of more than 90% of the microspheres is between 10 μm and 100 μm.

Embodiment 3

[0045]Add 0.5g of sodium alginate, 0.5g of carboxymethyl chitosan and 0.025g of collagen into 100ml of water and dissolve to prepare a matrix solution.

[0046] Mix 250ml of castor oil with 18.75ml of lecithin, add matrix solution, and 10ml of 2w / w% calcium chloride, accompanied by rapid stirring, to carry out cross-linking reaction to prepare microspheres.

[0047] After the end, add 500ml of ethanol and soak for 2 hours. After the microspheres and the solution are separated, remove the clear liquid, filter the precipitate to further remove the excess solution, and put it in a vacuum drying oven at 60°C for drying. The dried microspheres are detected by a laser diffraction particle size analyzer, and the particle size distribution of more than 90% of the microspheres is between 10 μm and 100 μm.

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Abstract

A microsphere is mainly composed of sodium alginate, carboxymethyl chitosan and collagen, and the contained collagen is more than 0.5w / w%. The liquid absorption multiple of the microsphere of the invention can reach more than 50, and can be used as a dressing for wound hemostasis.

Description

technical field [0001] The invention relates to a medical composite material, in particular to a microsphere, which has a high liquid absorption rate and can be applied in the medical field, such as wound hemostasis. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. With the aging of the population and the increase of chronic ulcer wounds, the biomaterials closely related to wound repair involve various dressings and coverings on the wound surface, and the market value of medical dressings is becoming more and more important. [0003] According to the "Wound Care Markets" report published by Kalorama Information in July 2012, due to the continuous increase of trauma such as natural disasters, wars and accidents, the global market volume of hemostasis and wound repair materials with vascul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/42
Inventor 杨玉民
Owner ZHEJIANG SANCHUANG BIOTECHNOLOGY CO LTD
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