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Rheum emodin complexes and preparation method and application thereof

A technology of emodin complexes and emodin, which is applied in the field of emodin complexes and their preparation, can solve problems such as anti-cancer research of emodin metal complexes that have not been seen, and achieve improved anti-cancer, strong inhibitory effect, and anti-oxidation Active effect

Inactive Publication Date: 2015-04-29
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on coordinating emodin with magnesium, calcium, chromium or cobalt, and there is no research on the use of emodin metal complexes to fight cancer

Method used

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  • Rheum emodin complexes and preparation method and application thereof
  • Rheum emodin complexes and preparation method and application thereof
  • Rheum emodin complexes and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 emodin magnesium (Ⅱ) complex

[0043] Weigh 1mmol emodin (270mg) and dissolve it in 60ml absolute ethanol, stir electromagnetically at room temperature, and obtain a yellow clear solution after most of the ligands are dissolved, add 0.5mmol (107.23mg) C 4 h 6 o 4 Mg·4H 2 O (magnesium acetate) in 15 mL of absolute ethanol solution, add ammonia water in ethanol solution (1:1, V:V) dropwise, adjust the pH of the ligand solution to 8-10, and continue to stir the reaction at a reaction temperature of 40°C After 12 hours, the solution was left to stand overnight for vacuum suction filtration, and the precipitate was washed several times with absolute ethanol and diethyl ether, respectively, and then vacuum-dried for 72 hours to obtain a powdery solid product, namely emodin magnesium (II) complex.

Embodiment 2

[0044] The preparation of embodiment 2 emodin calcium complexes

[0045] According to the method of Example 1, with CaCl 2 ·6H 2 O (calcium chloride) instead of zinc acetate, the reaction that is emodin calcium (Ⅱ) complex.

Embodiment 3

[0046] The preparation of embodiment 3 emodin chromium complexes

[0047] According to the method of embodiment 1, with CrCl 3 ·6H 2 O (chromium chloride) replaces zinc acetate, and reacts to obtain emodin chromium (Ⅲ) complexes.

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Abstract

The invention provides rheum emodin complexes or pharmaceutically acceptable salts, esters or hydrates thereof. The invention also provides a preparation method and application of the rheum emodin complexes. The complexes prepared from rheum emodin and magnesium, calcium, chromium or cobalt generate synergistic effect and the anticancer, antibacterial and antioxidant activity of the rheum emodin can be outstandingly enhanced; in addition, different rheum emodin complexes are quite different in biological activity on different medical application aspects. The invention accidentally finds that the rheum emodin magnesium (II) complex has highest anti-hepatoma activity, the rheum emodin chromium (III) complex has highest inhibiting effect on escherichia coli and the rheum emodin cobalt (II) complex has highest antioxidant activity, thereby providing a new selection for clinical medication.

Description

technical field [0001] The invention relates to an emodin complex and its preparation method and application. Background technique [0002] Emodin is an active ingredient in the traditional Chinese medicine cassia seed, rhubarb, knotweed, and rhubarb. Its chemical name is: 6-methyl-1,3,8-trihydroxy-9,10-anthraquinone, and its structural formula is as follows: [0003] [0004] Emodin is an anthraquinone compound containing α-phenolic hydroxyl groups, in which the 1,8-position hydroxyl group and the 9-position carbonyl group are suitable for coordinating with various metal ions to form complexes. Emodin has a wide range of sources and is easy to purify. Studies have shown that emodin has a good antioxidant effect. According to literature reports, after emodin cooperates with metal ions, its physiological activity will change. For example, studies by Xiang Hui and others have shown that emodin and Fe 2+ , Zn 2+， mn 2+ The antioxidative activity of the ion complexes was ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C50/34C07C46/00A61K31/122A61K31/28A61K31/295A61P35/00A61P31/04A61P39/06
CPCC07C46/00C07C50/34Y02A50/30
Inventor 潘晓丽
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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