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Method for preparing magnetic polymer microspheres by multiple emulsion method

A technology of polymer microspheres and double-emulsion method, which is applied in the field of magnetic polymer microspheres prepared by double-emulsion method, can solve the problems of magnetic aggregation and microbial decomposition of particles, and achieve short time, high reaction efficiency and simple process Effect

Inactive Publication Date: 2015-04-29
华文蔚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure magnetic nanoparticles are not feasible for practical applications. When they are exposed to biological systems, magnetic aggregation between particles is easy to occur and they are easily decomposed by microorganisms.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] First prepare ferric chloride solution; the concentration of ferric chloride is 0.1-10%; then under ultrasonic conditions, the polymerized monomer methyl methacrylate, styrene and acrylonitrile are made into a mixed solution in an organic solvent, The weight ratio in the mixed solution is methyl methacrylate: styrene: acrylonitrile=1: 2: 1; then the mixed solution is added with a surfactant, a crosslinking agent and an initiator under vigorous stirring, and the initiator is Benzoyl peroxide, the content is 1%; Surfactant is Tween 80; Mix above-mentioned solution, use ultrasonic crushing method, make W / O type stable colostrum emulsion; Add W / O colostrum emulsion to poly In the aqueous solution W2 with a vinyl alcohol content of 1%, use the homogeneous emulsification method to prepare a W / O / W2 type double emulsion; raise the temperature to copolymerize the monomers; add 1% ammonia water to the external water phase W2, stir, OH- diffuses into the inner water phase, reacts ...

Embodiment 2

[0020] First prepare ferric chloride solution; the concentration of ferric chloride is 10%; then under ultrasonic conditions, the polymerized monomer methyl methacrylate, styrene and acrylonitrile are made into a mixed solution in an organic solvent, and the mixed The weight ratio in the liquid is methyl methacrylate: styrene: acrylonitrile = 1: 2: 1; then the mixed liquid is added with surfactant, cross-linking agent and initiator under the condition of vigorous stirring, and the initiator is peroxide Benzoyl, the content is 1%; Surfactant is Tween 80; Mix above-mentioned solution, use ultrasonic crushing method, make W / O type stable colostrum emulsion; Add W / O colostrum emulsion to polyvinyl alcohol In the aqueous solution W2 with a content of 1%, use the homogeneous emulsification method to prepare a W / O / W2 type double emulsion; raise the temperature to copolymerize the monomers; add 1% ammonia water to the external aqueous phase W2, stir, and OH- Diffuse into the inner wat...

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PUM

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Abstract

The invention provides a method for preparing magnetic polymer microspheres by a multiple emulsion method. The method comprises the following craft processes and steps: A. preparing a ferric trichloride solution at first; B. then preparing polymeric monomers methyl methacrylate, styrene and acrylonitrile into a mixed solution in an organic solvent under ultrasonic conditions, and adding a surfactant, a cross-linking agent and an initiator into the mixed solution under an acute stirring condition; C. mixing the solutions in step A and B, and preparing W / O stable primary emulsion by using an ultraultrasonication method; adding the primary emulsion into an aqueous solution W2 with polyvinyl alcohol content of 1% to prepare W / O / W2 type compound emulsion; heating to copolymerize the monomers; adding 1% of ammonia water into an external aqueous phase W2, stirring to disperse OH<-> into an internal aqueous phase, and reacting with iron ions to generate magnetic granules; continuing to polymerize, evaporating the organic solvent in the droplets of the compound emulsion, and curing the droplets of the compound emulsion to produce the magnetic polymer microspheres; applying a magnetic field to separate the magnetic microspheres, repeatedly washing the magnetic microspheres with dilute acid, ethanol and deionized water, and drying to obtain a finished product.

Description

technical field [0001] The invention relates to a method for preparing magnetic polymer microspheres by double emulsion method. Background technique [0002] Magnetic polymer microspheres refer to embedding magnetic particles in polymer microspheres by appropriate methods to form microspheres with certain magnetic responsiveness and special structure. It is a new type of functional polymer composite material developed in the late 1970s. On the one hand, it has the characteristics of polymer microspheres. Through chemical reactions such as copolymerization and surface modification, the surface of polymer microspheres can be equipped with a variety of functional groups, so that it can bind a variety of biologically active substances; on the other hand, it It is also magnetic, and can be quickly separated from other non-magnetic substances under an external magnetic field, and the energy consumption is small. Therefore, as a new type of functional polymer material, magnetic p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F220/14C08F220/44C08F2/32C08F2/44C08K3/16C08J3/12B01J13/14
Inventor 华文蔚
Owner 华文蔚