Coriolus versicolor polysaccharide granule as well as preparation method and application thereof

A technology of Yunzhi polysaccharide and granule granule, which is applied in the fields of biotechnology, pharmacy and food science, can solve the problems such as the rare products of Yunzhi polysaccharide granule, achieve the reduction of atherosclerosis index, prolong storage time, and improve solubility Good results

Active Publication Date: 2015-05-06
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the development of Yunzhi polysaccharide granule products is still rare. This patent uses the development of Yunzhi polysaccharide granule products, and uses hyperlipidemia mouse experiments to identify the blood lipid-lowering effect of Yunzhi polysaccharide granule products. The health application of polysaccharide products provides a scientific basis

Method used

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  • Coriolus versicolor polysaccharide granule as well as preparation method and application thereof
  • Coriolus versicolor polysaccharide granule as well as preparation method and application thereof
  • Coriolus versicolor polysaccharide granule as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1) Coriolus versicolor (C.versicolor) is cultivated on a slant or plate, liquid shaking culture and liquid submerged fermentation culture to obtain mycelium and fermentation liquid. The specific methods are as follows:

[0062] ①Slant or plate strain culture: put the activated Mycelia block of Versicolor versicolor slant parent species into a new slant solid medium, culture at 24°C for 10 days, and store at 4°C for later use;

[0063] ②Level-1 liquid strain culture: Take 200mL liquid fermentation medium and put it into a 500mL Erlenmeyer flask, sterilize at 121°C for 20min, and insert 4 soybean-sized mycelia blocks of Versicolor versicolor parent species; let stand at room temperature for 24h, and wait for After the wounds of the bacteria block are healed, culture at 27°C, rotate at 150rpm, avoid light, and shake at constant temperature for 6 days to obtain the first-grade seed liquid;

[0064] ③Cultivation of secondary liquid strains: 50L seed tanks are filled with 35...

Embodiment 2

[0075] (1) Coriolus versicolor (C.versicolor) is cultivated on a slant or plate, liquid shaking culture and liquid submerged fermentation culture to obtain mycelium and fermentation liquid. The specific methods are as follows:

[0076] ①Slant or plate strain culture: put the activated mycelium block of Versicolor versicolor slant parent species into a new slant solid medium, culture at 25°C for 12 days, and store at 4°C for later use;

[0077] ②Level-1 liquid strain culture: Take 200mL liquid fermentation medium and put it into a 500mL Erlenmeyer flask, sterilize at 121°C for 20min, and insert 6 soybean-sized mycelia pieces of Versicolor versicolor; let it stand at room temperature for 24h, and wait for After the wounds of the bacteria block are healed, culture at 27°C, rotate at 150rpm, avoid light, and shake at constant temperature for 6 days to obtain the first-grade seed liquid;

[0078] ③Cultivation of secondary liquid strains: 50L seed tanks are filled with 35L of liquid...

Embodiment 3

[0089] (1) Coriolus versicolor (C.versicolor) is cultivated on a slant or plate, liquid shaking culture and liquid submerged fermentation culture to obtain mycelium and fermentation liquid. The specific methods are as follows:

[0090] ①Slant or plate strain culture: put the activated Mycelia block of Versicolor versicolor slant parent species into a new slant solid medium, culture at 27°C for 15 days, and store at 4°C for later use;

[0091] ②Level-1 liquid strain culture: Take 200mL liquid fermentation medium and put it into a 500mL Erlenmeyer flask, sterilize at 121°C for 20min, and insert 5 soybean-sized mycelium blocks of Versicolor versicolor parent species; let it stand at room temperature for 24h, and wait for After the wounds of the bacteria block are healed, culture at 27°C, rotate at 150rpm, avoid light, and shake at constant temperature for 6 days to obtain the first-grade seed liquid;

[0092] ③Cultivation of secondary liquid strains: 50L seed tanks are filled wit...

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Abstract

The invention belongs to the fields of biotechnology, pharmacy and food science, and particularly relates to a coriolus versicolor polysaccharide granule as well as a preparation method and application thereof. A coriolus versicolor polysaccharide extract is taken as a main raw material, and is added with a proper amount of auxiliary materials. The preparation method comprises the following steps: mixing and stirring components of the coriolus versicolor polysaccharide granule evenly; preparing a soft material with ethanol; and sieving, drying, sieving and pelletizing, so as to prepare the coriolus versicolor polysaccharide granule. The granule disclosed by the invention is simple in preparation process; the conditions are easy to control; the storage time of the prepared granule is obviously prolonged; the granule is easily dissolved into water; compared with a sugar-containing granule, the coriolus versicolor polysaccharide granule has the characteristics of good solubility and moisture resistance, is capable of removing the smell and improving the curative effect, is suitable for hyperlipidaemia, and has a good antihyperlipidemic effect; and the application range is expanded.

Description

technical field [0001] The invention belongs to the fields of biotechnology, pharmacy and food science, and specifically relates to a versicolor polysaccharide granule and a preparation method and application thereof. Background technique [0002] Yunzhi polysaccharides come from the intracellular polysaccharides in the versicolor mycelium cultured in liquid or the exopolysaccharides in the fermentation broth. Studies have found that Yunzhi polysaccharide can reduce the level of lipid peroxidation in rat brain tissue and accelerate the scavenging of free radicals (Chen et al., 2013). In particular, Rao Gang et al. verified through clinical observation that polysaccharides from Versicolor polysaccharides have obvious curative effects on hyperlipidemia and are a safe preparation (Gang Rao, 2007). Wang Hong and others also found that PSK has a certain effect of lowering blood lipids, has a certain timeliness and improves the stickiness, coagulation and aggregation state of blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/715A61K47/36A61P9/10A61P3/06A61P1/16A23L1/09A23L33/125
Inventor 张松冯伟红陈瑞荣
Owner SOUTH CHINA NORMAL UNIVERSITY
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