Method for preparing pediatric paracetamol and amantadine hydrochloride granules

Abstract

The invention discloses a method for preparing pediatric paracetamol and amantadine hydrochloride granules. The method comprises the following steps: uniformly mixing chlorpheniramine maleate, caffeine, calculus bovis factitius, amantadine hydrochloride and acetaminophen at a weight ratio, weighting to obtain a mixture and fully grinding the mixture to obtain a pre-mixed material; placing the pre-mixed material into a granulator and adding excipients into the granulator to prepare drug granules; and drying the drug granules, granulating, carrying out total mixing treatment and packaging into packaging bags to obtain the pediatric paracetamol and amantadine hydrochloride granules. The preparation process is simplified, the raw material loss during the preparation process of the pediatric paracetamol and amantadine hydrochloride granules is decreased, the preparation cost of the pediatric paracetamol and amantadine hydrochloride granules is decreased, the preparation environment is relatively smooth in the preparation process of the pediatric paracetamol and amantadine hydrochloride granules, the dramatic physical and chemical changes generate by each component is avoided and the pharmaceutical efficacy and purity of the pediatric paracetamol and amantadine hydrochloride granules are increased.

Description

technical field [0001] The invention relates to a preparation method of pediatric acetaminophen granules. Background technique [0002] A common cold is a common disease caused by exogenous evils. The clinical manifestations are nasal congestion, runny nose, sneezing, coughing, headache, chills, fever, general malaise and other symptoms. A cold belongs to the adult viral upper respiratory tract infection condition of modern medicine. Although a cold has certain Self-healing, but some patients can induce pulmonary complications, severe secondary syndromes such as toxic shock, and even endanger the patient's life. [0003] Most colds are caused by viruses invading the human body through the respiratory tract or sweat glands. During the treatment process, most doctors prescribe antibiotics. Although antibiotics have a good therapeutic effect on colds, long-term use of antibiotics is easy to make patients Drug resistance is formed, and when antibiotics are used, the patient's i...

AI Technical Summary

Problems solved by technology

[0003] For colds, most of them are caused by viruses invading the human body through the respiratory tract or sweat glands. During the treatment, most doctors prescribed antibiotics. Although antibiotics have a good therapeutic effect on colds, long-term use of antibiotics is easy to make patients Formation of drug resistance, and the use of antibiotics will more or less damage the patient's immune system

In most cases, patients are treated with chemical drugs or compound preparations of Chinese and Western medicines, but these drugs basically contain antipyretic and pain-relieving, nasal mucosal vasoconstriction, and central excitatory ingredients. Side effects such as drowsiness, especially for infants and young children

However, in the prior art, the technological process for preparing Pediatric Amphenol Alkamine Granules is too complicated, and it is easy to cause waste of raw materials in the preparation process, and it is also easy to cause relatively large physical and chemical changes in the raw materials during the preparation process, which affects the efficacy of the drug.