A kind of preparation method of 2,5-dialkoxy dihydrofuran compound

A dialkoxydihydrofuran and compound technology, which is applied in the field of preparation of 2,5-dialkoxydihydrofuran compounds, can solve the problems of low product yield, toxic solvent benzene, and low utilization rate of furan, etc. , to achieve the effect of simple reaction method, low production cost and convenient operation
CN104592175BActive Publication Date: 2017-01-25JIANGSU QINGQUAN CHEM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU QINGQUAN CHEM CO LTD
Publication Date
2017-01-25

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Abstract

The invention provides a preparation method of a 2,5-dialkoxyl dihydrofuran compound. The preparation method comprises the following steps: adding a furan compound shown by a formula I, alkyl alcohol shown by a formula III and an acid-binding agent into a reactor, stirring to react with chlorine, keeping the reaction temperature to be (-25)-25 DEG C, and reacting to obtain a 2,5-dialkoxyl dihydrofuran compound shown by a formula II, wherein in the formulas, R1, R2, R3 and R4 are independent hydrogen, halogen and C1-C5 alkyl, and R1 is a C1-C12 alkyl. The method provided by the invention is less in investment, low in energy consumption and high in efficiency; the reaction method is simple, and the operation is convenient and easy to implement; the raw materials are low in price, easy to obtain, and low in production cost; a byproduct is salt and can meet requirements on environmental protection; and the preparation method is suitable for performing industrial large-scale production of the 2,5-dialkoxyl dihydrofuran compound. Particularly, when a phase transfer catalyst is added into the method provided by the invention, the method also has the advantage that the yield of a target product is obviously improved.
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Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a preparation method of 2,5-dialkoxydihydrofuran compounds. Background technique

[0002] 2,5-dialkoxydihydrofuran compounds are a class of important pharmaceutical intermediates and spice intermediates. For example, 2,5-dimethoxydihydrofuran is an intermediate in the synthesis of anticholinergic drugs atropine sulfate and anisodamine hydrobromide. It can be hydrolyzed and hydrogenated with hydrochloric acid to prepare the important fine petrochemical intermediate succinaldehyde, and it can also be catalytically hydrogenated to obtain 2,5-dimethoxytetrahydrofuran. For example, 2-methyl-2,5-dimethoxydihydrofuran is an indispensable raw material for blending flavors and fragrances, and is widely used in seafood and seafood flavors.

[0003] Among the 2,5-dialkoxydihydrofuran compounds, there are two typical synthesis techniques of 2,5-dimethoxydihydrofuran as follows. 1. Electro...

Claims

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