Cannabis plant isolate comprising /\9-tetrahydrocannabinol and a method for preparing such an isolate

A technology for tetrahydrocannabinol and isolates, which is applied in the field of preparing cannabis plant Δ9-tetrahydrocannabinol isolates, can solve the problems of low THC yield, residue, and cumbersome methods, and achieve highly repeatable results

Inactive Publication Date: 2015-05-13
ECHO PHARM BV (NL)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the method discloses an extract containing at least 99% THC by weight, the method is cumbersome and the chromatographic separation solvents used, such as methylene chloride and chloroform, are considered to be health risks
Also, some solvents, such as methanol, may remain in the obtained product
Also, since the columns are used successively from one batch to another, variations in the purity of the obtained cannabinoids occur frequently
The yield of THC obtained by this method is also relatively low

Method used

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  • Cannabis plant isolate comprising /\9-tetrahydrocannabinol and a method for preparing such an isolate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The preparation method of the cannabis plant 9-tetrahydrocannabinol (THC) isolate according to the present invention is as follows.

[0093] 2 kg of cannabis flowers (ie, flowers) obtained from the hemp plant were heated to approximately 100° C. to decarboxylate the cannabinoid acids present in the cannabis flowers. The decarboxylated cannabis flower (1.8 kg) was then mixed with hexane (1 g cannabis flower per 10 ml hexane) to extract cannabinoids from said cannabis flower. The extract was isolated from the flowers and dried to dryness in a rotary evaporator. The solvent extract (about 600 g) contained about 55% THC by dry weight.

[0094] Subsequently, the dried extract was introduced into methanol (1 g of dried extract per 2 ml of methanol) and cooled to -10 °C, then filtered and centrifuged at 5000 RPM at a temperature of 6 °C (Beckman Coulter, model Avanti J-26xp )25min. Activated charcoal of p.a. grade purity was added to the obtained methanol solvent mixture at...

Embodiment 2

[0099] The preparation of tablets containing the 9-tetrahydrocannabinol (THC) isolate of the cannabis plant obtained by the method described in Example 1 is as follows.

[0100] Sucrose monolaurate (HLB=15) and cannabis plant THC isolate were heated to 120°C under nitrogen flow. The weight ratio of THC and sucrose monolaurate is 1:15. After thorough mixing, the putty-like melt was washed with CO using either of the following methods: 2 Saturation (and thus softening):

[0101] - Inject the warm melt into a preheated autoclave at 120°C and pressurize to 250 bar. The autoclave was pressurized with carbon dioxide with a plunger pump (LeWa) and heated with heating oil through a jacket. The dough was heated by CO at a supercritical rate using a Buchi(TM) magnetic stirrer. 2 Stir the melt for at least 30 min, pass it through CO 2 Saturation way to further liquefaction.

[0102] - Cool the melt to -20°C and crush for maximum surface area. For this, use -20 °C pre-cooled mortar...

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Abstract

The present invention relates to a method for preparing a Cannabis plant Δ9-tetrahydrocannabinol isolate from a crude solvent extract of Cannabis plant material. The invention relates further to a Cannabis plant THC isolate comprising Δ9-tetrahydrocannabinol, Cannabinol (CBN) and / or Cannabidiol (CBD) and to a pharmaceutical composition comprising the Cannabis plant THC isolate.

Description

technical field [0001] The present invention relates to a process for the preparation of a cannabis plant Δ9-tetrahydrocannabinol isolate from a crude solvent extract of cannabis plant material. The present invention further relates to a THC isolate of a cannabis plant containing Δ9-tetrahydrocannabinol, cannabinol (CBN) and / or cannabidiol (CBD) and to a pharmaceutical composition containing said THC isolate of a cannabis plant . Background technique [0002] Cannabis has been used over the years as a medicinal treatment for many diseases and conditions. Interest in the pharmacology of cannabis dates back hundreds of years. In addition to their use as anesthetics, antispasmodics and sleeping pills, cannabinoids are also used to treat vomiting and nausea caused by cancer chemotherapy and are also used in the treatment of glaucoma. Recently, cannabinoids have been implicated in sepsis due to their potential for abuse. A considerable amount of synthetic effort has been dire...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K36/185A61K31/352
CPCA61K31/35A61K31/352A61K36/185A61K2236/39A61P25/04C07D311/80
Inventor M·V·费尔南德斯赛德D·范霍滕
Owner ECHO PHARM BV (NL)
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